RESEARCH ARTICLE
Maternal vitamin D insufficiency and risk of adverse pregnancy and birth outcomes: A systematic review and meta-analysis of longitudinal studies A. Kofi Amegah1*, Moses K. Klevor2, Carol L. Wagner3 1 Public Health Research Group, Department of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana, 2 Department of Clinical Nutriton and Dietetics, University of Cape Coast, Cape Coast, Ghana, 3 Medical University of South Carolina Children’s Hospital, Charleston, SC, United States of America * [email protected]
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Abstract Background
OPEN ACCESS Citation: Amegah AK, Klevor MK, Wagner CL (2017) Maternal vitamin D insufficiency and risk of adverse pregnancy and birth outcomes: A systematic review and meta-analysis of longitudinal studies. PLoS ONE 12(3): e0173605. https://doi.org/10.1371/journal.pone.0173605 Editor: Tuan Van Nguyen, Garvan Institute of Medical Research, AUSTRALIA Received: July 21, 2016 Accepted: February 23, 2017 Published: March 17, 2017 Copyright: © 2017 Amegah et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper. Funding: The authors received no funding for this work. Competing interests: The authors have declared that no competing interests exist.
Three previous reviews on the association of vitamin D insufficiency in pregnancy with preterm birth (PTB) and stillbirth were limited in scope and deemed inconclusive. With important new evidence accumulating, there is the need to update the previous estimates and assess evidence on other clinically important outcomes such as spontaneous abortion and Apgar score. We conducted a systematic review and meta-analysis to evaluate the quality and strength of the available evidence on the relations between vitamin D nutritional status, and pregnancy and birth outcomes.
Methods PubMed and Scopus databases were searched from their inception to June, 2015 with no language restrictions imposed. Eighteen longitudinal studies satisfied the inclusion criteria. Random effects model was applied in computing the summary effect estimates and their corresponding 95% confidence intervals.
Results Serum 25(OH)D levels
Maternal vitamin D insufficiency and risk of adverse pregnancy and birth outcomes: A systematic review and meta-analysis of longitudinal studies A. Kofi Amegah1*, Moses K. Klevor2, Carol L. Wagner3 1 Public Health Research Group, Department of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana, 2 Department of Clinical Nutriton and Dietetics, University of Cape Coast, Cape Coast, Ghana, 3 Medical University of South Carolina Children’s Hospital, Charleston, SC, United States of America * [email protected]
a1111111111 a1111111111 a1111111111 a1111111111 a1111111111
Abstract Background
OPEN ACCESS Citation: Amegah AK, Klevor MK, Wagner CL (2017) Maternal vitamin D insufficiency and risk of adverse pregnancy and birth outcomes: A systematic review and meta-analysis of longitudinal studies. PLoS ONE 12(3): e0173605. https://doi.org/10.1371/journal.pone.0173605 Editor: Tuan Van Nguyen, Garvan Institute of Medical Research, AUSTRALIA Received: July 21, 2016 Accepted: February 23, 2017 Published: March 17, 2017 Copyright: © 2017 Amegah et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper. Funding: The authors received no funding for this work. Competing interests: The authors have declared that no competing interests exist.
Three previous reviews on the association of vitamin D insufficiency in pregnancy with preterm birth (PTB) and stillbirth were limited in scope and deemed inconclusive. With important new evidence accumulating, there is the need to update the previous estimates and assess evidence on other clinically important outcomes such as spontaneous abortion and Apgar score. We conducted a systematic review and meta-analysis to evaluate the quality and strength of the available evidence on the relations between vitamin D nutritional status, and pregnancy and birth outcomes.
Methods PubMed and Scopus databases were searched from their inception to June, 2015 with no language restrictions imposed. Eighteen longitudinal studies satisfied the inclusion criteria. Random effects model was applied in computing the summary effect estimates and their corresponding 95% confidence intervals.
Results Serum 25(OH)D levels
