003 1-3998/92/3 102-0151$03.00/0 PEDIATRIC RESEARCH Copyright O 1992 International Pediatric Research Foundation, Inc.
Vol. 31, No. 2, 1992 Printed in U.S. A.
Maturational Changes in Airway Smooth Muscle Structure-Function Relationships HOWARD B. PANITCH, KIRAN S. DEORAS, MARLA R. WOLFSON, AND THOMAS H. SHAFFER
Departments of Pediatrics and Physiology, St. Christopher's Hospital for Children, Temple University School of Medicine, Philadelphia, Pennsylvania 19134-1095
ABSTRACT. Airways become less compliant with age. When examined at either extreme of the developmental spectrum, airway smooth muscle (ASM) undergoes changes that parallel the trachea: both passive and active stress increase from preterm to adult. To determine how ASM changes throughout maturation, trachealis muscles from sheep airways of five age groups (group 1,
Vol. 31, No. 2, 1992 Printed in U.S. A.
Maturational Changes in Airway Smooth Muscle Structure-Function Relationships HOWARD B. PANITCH, KIRAN S. DEORAS, MARLA R. WOLFSON, AND THOMAS H. SHAFFER
Departments of Pediatrics and Physiology, St. Christopher's Hospital for Children, Temple University School of Medicine, Philadelphia, Pennsylvania 19134-1095
ABSTRACT. Airways become less compliant with age. When examined at either extreme of the developmental spectrum, airway smooth muscle (ASM) undergoes changes that parallel the trachea: both passive and active stress increase from preterm to adult. To determine how ASM changes throughout maturation, trachealis muscles from sheep airways of five age groups (group 1,
