Graefes Arch Clin Exp Ophthalmol (2015) 253:2047–2048 DOI 10.1007/s00417-015-3047-6
LETTER TO THE EDITOR (BY INVITATION)
Mean platelet volume in retinopathy of prematurity Yuan Tao 1 & Yu Dong 2 & Cheng-wei Lu 2 & Wei Yang 2
Received: 24 April 2015 / Accepted: 29 April 2015 / Published online: 10 May 2015 # Springer-Verlag Berlin Heidelberg 2015
Dear Editor, The authors would like to thank Dr. Sahin and colleagues for their insightful suggestions regarding our paper. Firstly, Sahin questions the sentence, BTo our knowledge, there is only one study that investigates the possible relationship between MPV values and occurrence of ROP in preterm infants.^ This viewpoint was proposed based on our previous detailed investigation. We have thoroughly searched the NHI PubMed electronic database for studies on the relationship between ROP and MPV. Regrettably, the article published by Sahin et al. [1] can’t be found, as it is not indexed in PubMed. We have now searched for and found the article using Google Scholar, and have read the remarkable work with great respect. Dr. Sahin and colleagues have undoubtedly done outstanding research on MPV in ROP. Secondly, we agree with Sahin’s comments on the study of Cekmez et.al. [2]. In fact, a similar viewpoint also can be found in the discussion section (paragraph 2) within our article, which states B…the overproduction of growth factors and the critical stage of ROP occur most frequently around 33– 34 weeks postconception. We hypothesized that activities and
* Yu Dong [email protected] Yuan Tao [email protected] 1
Department of Ophthalmology, The First Affiliated Hospital of Dalian Medical University, Dalian, China
2
Department of Ophthalmology, The First Hospital of Jilin University, No.71 Xin Min Road, Changchun, 130021 Jilin, China
p a r a m e t e r s o f p l at e l e t s d i r e c t l y p r e c ed i n g l as e r treatment….would better reflect the occurrence and development of ROP.^ Thirdly, Sahin held that blood transfusion may alter MPV, according to the study of Dr. Frey [3]. However, Frey’s study only proves the relationship between transfusion and platelet count, and the MPV value is not mentioned. As we didn’t find direct proof of the influence in previous investigations, and as blood transfusion is not a common exclusion criterion in other similar MPV research involving the relationships between MPV and type 2 diabetes mellitus [4–6], coronary disease [7], cancer [8, 9], psoriasis vulgaris [10], etc., we did not exclude patients who had undergone blood transfusion in our study. Nevertheless, Sahin’s insightful comments are very reasonable. The influence of blood transfusion is worth consideration. In order to see whether the results can be changed after excluding blood transfusion, we further reviewed the medical records of 148 enrolled infants and performed more statistical analysis. When blood transfusion and relevant parameters are excluded, the mean platelet volume values are still found to be statistically significantly higher in patients with ROP than in controls (10.67±1.34 fl vs. 10.10±0.92 fl, p=0.02). Therefore, we have proven that whether or not transfusion and sepsis are excluded does not change the conclusion that MPV is associated with type 1 ROP. Finally, we appreciate Sahin’s valuable comments and are grateful to show a detailed study as follows. Infants with blood transfusion, blood exchange, sepsis, and hematological disorders were excluded from the study. Fifty-two infants included in previous study were excluded. Comparisons of parametric between groups were performed using Student’s t-test. Multivariate logistic regression analysis was performed to determine risk
2048 Table 1
Graefes Arch Clin Exp Ophthalmol (2015) 253:2047–2048 Comparison of type 1 ROP and controls
Conflict of interest The authors declare no funding and no competing interest in the preparation of this manuscript. The authors have no financial interest in the research.
Case (n=48)
Control (n=48)
p value
29.77 (1.87) 29.50 (26, 35)
30.00 (1.50) 30 (26, 33)
0.51
1418.92 (388.55) 1305 (750, 2900)
1488.96 (271.69) 1500 (850, 1950)
0.28
1.
10.10 (0.92) 10 (8, 13)
0.02
2.
341.98 (121.24) 303.5 (130, 664)
0.46
Gestational age (weeks) Mean (SD) Median (min, max) Birth weight (grams) Mean (SD) Median (min, max) MPV (fl)
Mean (SD) 10.67 (1.34) Median (min, max) 10.60 (8.4, 14) Platelet count (×109/L) Mean (SD) Median (min, max)
325.31 (98.22) 321 (141, 686)
References
3.
SD standard deviation 4.
factors. SAS 9.2 for Windows was used for all statistical measurements. Results were evaluated at the p
LETTER TO THE EDITOR (BY INVITATION)
Mean platelet volume in retinopathy of prematurity Yuan Tao 1 & Yu Dong 2 & Cheng-wei Lu 2 & Wei Yang 2
Received: 24 April 2015 / Accepted: 29 April 2015 / Published online: 10 May 2015 # Springer-Verlag Berlin Heidelberg 2015
Dear Editor, The authors would like to thank Dr. Sahin and colleagues for their insightful suggestions regarding our paper. Firstly, Sahin questions the sentence, BTo our knowledge, there is only one study that investigates the possible relationship between MPV values and occurrence of ROP in preterm infants.^ This viewpoint was proposed based on our previous detailed investigation. We have thoroughly searched the NHI PubMed electronic database for studies on the relationship between ROP and MPV. Regrettably, the article published by Sahin et al. [1] can’t be found, as it is not indexed in PubMed. We have now searched for and found the article using Google Scholar, and have read the remarkable work with great respect. Dr. Sahin and colleagues have undoubtedly done outstanding research on MPV in ROP. Secondly, we agree with Sahin’s comments on the study of Cekmez et.al. [2]. In fact, a similar viewpoint also can be found in the discussion section (paragraph 2) within our article, which states B…the overproduction of growth factors and the critical stage of ROP occur most frequently around 33– 34 weeks postconception. We hypothesized that activities and
* Yu Dong [email protected] Yuan Tao [email protected] 1
Department of Ophthalmology, The First Affiliated Hospital of Dalian Medical University, Dalian, China
2
Department of Ophthalmology, The First Hospital of Jilin University, No.71 Xin Min Road, Changchun, 130021 Jilin, China
p a r a m e t e r s o f p l at e l e t s d i r e c t l y p r e c ed i n g l as e r treatment….would better reflect the occurrence and development of ROP.^ Thirdly, Sahin held that blood transfusion may alter MPV, according to the study of Dr. Frey [3]. However, Frey’s study only proves the relationship between transfusion and platelet count, and the MPV value is not mentioned. As we didn’t find direct proof of the influence in previous investigations, and as blood transfusion is not a common exclusion criterion in other similar MPV research involving the relationships between MPV and type 2 diabetes mellitus [4–6], coronary disease [7], cancer [8, 9], psoriasis vulgaris [10], etc., we did not exclude patients who had undergone blood transfusion in our study. Nevertheless, Sahin’s insightful comments are very reasonable. The influence of blood transfusion is worth consideration. In order to see whether the results can be changed after excluding blood transfusion, we further reviewed the medical records of 148 enrolled infants and performed more statistical analysis. When blood transfusion and relevant parameters are excluded, the mean platelet volume values are still found to be statistically significantly higher in patients with ROP than in controls (10.67±1.34 fl vs. 10.10±0.92 fl, p=0.02). Therefore, we have proven that whether or not transfusion and sepsis are excluded does not change the conclusion that MPV is associated with type 1 ROP. Finally, we appreciate Sahin’s valuable comments and are grateful to show a detailed study as follows. Infants with blood transfusion, blood exchange, sepsis, and hematological disorders were excluded from the study. Fifty-two infants included in previous study were excluded. Comparisons of parametric between groups were performed using Student’s t-test. Multivariate logistic regression analysis was performed to determine risk
2048 Table 1
Graefes Arch Clin Exp Ophthalmol (2015) 253:2047–2048 Comparison of type 1 ROP and controls
Conflict of interest The authors declare no funding and no competing interest in the preparation of this manuscript. The authors have no financial interest in the research.
Case (n=48)
Control (n=48)
p value
29.77 (1.87) 29.50 (26, 35)
30.00 (1.50) 30 (26, 33)
0.51
1418.92 (388.55) 1305 (750, 2900)
1488.96 (271.69) 1500 (850, 1950)
0.28
1.
10.10 (0.92) 10 (8, 13)
0.02
2.
341.98 (121.24) 303.5 (130, 664)
0.46
Gestational age (weeks) Mean (SD) Median (min, max) Birth weight (grams) Mean (SD) Median (min, max) MPV (fl)
Mean (SD) 10.67 (1.34) Median (min, max) 10.60 (8.4, 14) Platelet count (×109/L) Mean (SD) Median (min, max)
325.31 (98.22) 321 (141, 686)
References
3.
SD standard deviation 4.
factors. SAS 9.2 for Windows was used for all statistical measurements. Results were evaluated at the p
