NIH Public Access Author Manuscript Int J Body Compos Res. Author manuscript; available in PMC 2014 October 10.
NIH-PA Author Manuscript
Published in final edited form as: Int J Body Compos Res. 2011 December ; 9(4): 147–.
Mechanistic model of mass-specific basal metabolic rate: evaluation in healthy young adults Z. Wang1, A. Bosy-Westphal2, B. Schautz2, and M. Müller2 1Obesity
Research Center, St. Luke’s-Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York City, USA 2Institute
of Human Nutrition and Food Science, Christian-Albrechts University, Kiel, Germany
Abstract NIH-PA Author Manuscript
Mass-specific basal metabolic rate (mass-specific BMR), defined as the resting energy expenditure per unit body mass per day, is an important parameter in energy metabolism research. However, a mechanistic explanation for magnitude of mass-specific BMR remains lacking. The objective of the present study was to validate the applicability of a proposed mass-specific BMR model in healthy adults. A mechanistic model was developed at the organ-tissue level, massspecific BMR = Σ(Ki × Fi), where Fi is the fraction of body mass as individual organs and tissues, and Ki is the specific resting metabolic rate of major organs and tissues. The Fi values were measured by multiple MRI scans and the Ki values were suggested by Elia in 1992. A database of healthy non-elderly non-obese adults (age 20 – 49 yrs, BMI
NIH-PA Author Manuscript
Published in final edited form as: Int J Body Compos Res. 2011 December ; 9(4): 147–.
Mechanistic model of mass-specific basal metabolic rate: evaluation in healthy young adults Z. Wang1, A. Bosy-Westphal2, B. Schautz2, and M. Müller2 1Obesity
Research Center, St. Luke’s-Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York City, USA 2Institute
of Human Nutrition and Food Science, Christian-Albrechts University, Kiel, Germany
Abstract NIH-PA Author Manuscript
Mass-specific basal metabolic rate (mass-specific BMR), defined as the resting energy expenditure per unit body mass per day, is an important parameter in energy metabolism research. However, a mechanistic explanation for magnitude of mass-specific BMR remains lacking. The objective of the present study was to validate the applicability of a proposed mass-specific BMR model in healthy adults. A mechanistic model was developed at the organ-tissue level, massspecific BMR = Σ(Ki × Fi), where Fi is the fraction of body mass as individual organs and tissues, and Ki is the specific resting metabolic rate of major organs and tissues. The Fi values were measured by multiple MRI scans and the Ki values were suggested by Elia in 1992. A database of healthy non-elderly non-obese adults (age 20 – 49 yrs, BMI
