Original Article http://dx.doi.org/10.4070/kcj.2016.46.3.384 Print ISSN 1738-5520 • On-line ISSN 1738-5555
Korean Circulation Journal
Medication Adherence and the Occurrence of Complications in Patients with Newly Diagnosed Hypertension Hyun-Jin Kim, PhD1, Seok-Jun Yoon, MD2, In-Hwan Oh, MD3, Jae Hee Lim, MS3, and Young Ae Kim, PhD4 1
Department of Rehabilitation Standard & Policy, Korea National Rehabilitation Research Institute, Seoul, 2Department of Preventive Medicine, Korea University College of Medicine, Seoul, 3Department of Preventive Medicine, Kyung Hee University College of Medicine, Seoul, 4Cancer Policy Branch, National Cancer Control Institute, National Cancer Center, Goyang, Korea
Background and Objectives: In this retrospective cohort study, we sought to elucidate the relationship between medication adherence (MA) and the incidence of complications in patients with newly diagnosed hypertension. Subjects and Methods: Using claims data from the National Health Insurance Service, we measured health outcomes based on levels of MA, analyzed the incidence of complications in patients with a good MA, and clarified factors that may affect or predict MA. Results: In 2008, a total of 4294773 patients were diagnosed with hypertension and were subsequently prescribed anti-hypertensive medications. In the present study, we enrolled 564782 patients who met our inclusion/exclusion criteria. The 40-59% medication possession ratio (MPR) group had a 1.36 times higher risk of developing complications (95% confidence interval [CI]: 1.27-1.45) than did the MPR≥ 80% group, as revealed through Cox’s proportional hazards analysis. Similarly, the
Korean Circulation Journal
Medication Adherence and the Occurrence of Complications in Patients with Newly Diagnosed Hypertension Hyun-Jin Kim, PhD1, Seok-Jun Yoon, MD2, In-Hwan Oh, MD3, Jae Hee Lim, MS3, and Young Ae Kim, PhD4 1
Department of Rehabilitation Standard & Policy, Korea National Rehabilitation Research Institute, Seoul, 2Department of Preventive Medicine, Korea University College of Medicine, Seoul, 3Department of Preventive Medicine, Kyung Hee University College of Medicine, Seoul, 4Cancer Policy Branch, National Cancer Control Institute, National Cancer Center, Goyang, Korea
Background and Objectives: In this retrospective cohort study, we sought to elucidate the relationship between medication adherence (MA) and the incidence of complications in patients with newly diagnosed hypertension. Subjects and Methods: Using claims data from the National Health Insurance Service, we measured health outcomes based on levels of MA, analyzed the incidence of complications in patients with a good MA, and clarified factors that may affect or predict MA. Results: In 2008, a total of 4294773 patients were diagnosed with hypertension and were subsequently prescribed anti-hypertensive medications. In the present study, we enrolled 564782 patients who met our inclusion/exclusion criteria. The 40-59% medication possession ratio (MPR) group had a 1.36 times higher risk of developing complications (95% confidence interval [CI]: 1.27-1.45) than did the MPR≥ 80% group, as revealed through Cox’s proportional hazards analysis. Similarly, the
