EuroPRevent Congress Abstracts May 2015

Moderated Poster Session IV - Prevention, Epidemiology & Population Science Friday, 15 May 2015, 15:30–16:30 P421 High cardiorespiratory fitness abolishes the negative effect of long sedentary time on cardiovascular risk factor clustering. The HUNT Study, Norway

J Javaid Nauman1, D Stensvold1, J Coombes2, U Wisloff1 1 Department of Circulation and Medical Imaging, DMF, NTNU , Trondheim, Norway, 2 University Of Queensland, School of Human Movement Studies, The University of Queensland, St. Lucia, Brisbane, Australia Topic: Epidemiology Purpose: Finding effective ways of preventing cardiovascular risk factors (CV-RF) clustering is a major aim in preventive medicine and an important goal of current recommendation for physical activity (PA). Whether a high level of cardiorespiratory fitness (CRF) can modify the deleterious health consequences related to high sedentary time (ST) is not known. The aim of this study was to examine the potential modifying effect of CRF on the association between ST and CV-RF clustering. Methods: Cross-sectional study of 12274 men and 14209 women (20 years) without known cardiovascular disease in Norway. Self-reported ST measurements during a regular day were divided into three sample specific equally sized groups (4, 5-43.3 mLoˆn˜kg-1oˆn˜min-1 in men, and VO2peak>35.2 mLoˆn˜kg-1oˆn˜min-1 in women), the adjusted ORs associated with 7 h/day of ST were 0.92 (95% CI, 0.56-1.51) for men, and 1.16 (95% CI, 0.49-2.74) for women with high fitness levels, compared with the men and women with low ST (4 h/day) and high fitness levels. In combined analyses of fitness, PA and ST, compared with the reference group of participants meeting the recommendations, 4 h/day of ST and high fitness, the adjusted ORs were 0.63 (95% CI, 0.27-1.44) and 0.65 (95% CI, 0.14-3.07) in fit men and women with 7 h/day of ST, and not meeting the recommendations. Men and women meeting the PA recommendations, but being unfit (VO2peak

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