HHS Public Access Author manuscript Author Manuscript
Lancet Glob Health. Author manuscript; available in PMC 2017 July 03. Published in final edited form as: Lancet Glob Health. 2016 January ; 4(1): e57–e68. doi:10.1016/S2214-109X(15)00215-6.
Mortality and its risk factors in Malawian children admitted to hospital with clinical pneumonia, 2001–12: a retrospective observational study
Author Manuscript
Marzia Lazzerini, PhD, WHO Collaborating Centre for Maternal and Child Health, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy Nadine Seward, PhD, Institute for Global Health, University College London, London, UK Norman Lufesi, MPhil, Acute Respiratory Infection Control Programme, Community Health Sciences Unit, Lilongwe, Malawi Rosina Banda, BScNE, Parent and Child Health Initiative (PACHI), Lilongwe, Malawi Sophie Sinyeka, MSc, Parent and Child Health Initiative (PACHI), Lilongwe, Malawi
Author Manuscript
Gibson Masache, MSc, Parent and Child Health Initiative (PACHI), Lilongwe, Malawi Bejoy Nambiar, MPH, Institute for Global Health, University College London, London, UK Charles Makwenda, MSc, Parent and Child Health Initiative (PACHI), Lilongwe, Malawi Anthony Costello, FMedSci [Prof.], Institute for Global Health, University College London, London, UK Eric D McCollum, MD, and Institute for Global Health, University College London, London, UK
Author Manuscript
Correspondence to: Dr Tim Colbourn, Institute for Global Health, University College London, London WC1N 1EH, UK, [email protected]. Dr M Lazzerini, WHO Collaborating Centre for Maternal and Child Health, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34137, Trieste, Italy, [email protected]. Contributors ML designed this study with major inputs from NL, TC, NS, GM, BN, and AC. ML, NL, RB, SS, GM, and CM were involved in data collection in Malawi. NS was responsible for data cleaning, which was checked by TC. ML and NS did the descriptive and univariable mortality analyses, NS did the multivariable and multiple imputation analyses, and TC checked all analyses. ML wrote the first draft of the Article, with major contributions from TC, AC, NL, BN, NS, and EDM. All authors reviewed subsequent drafts and agreed on the final version of this paper. Declaration of interests We declare no competing interests.
Lazzerini et al.
Page 2
Author Manuscript
Johns Hopkins School of Medicine, Department of Pediatrics, Division of Pulmonology, Baltimore, MD, USA Tim Colbourn, PhD Institute for Global Health, University College London, London, UK
Summary Background—Few studies have reported long-term data on mortality rates for children admitted to hospital with pneumonia in Africa. We examined trends in case fatality rates for all-cause clinical pneumonia and its risk factors in Malawian children between 2001 and 2012.
Author Manuscript
Methods—Individual patient data for children (
Lancet Glob Health. Author manuscript; available in PMC 2017 July 03. Published in final edited form as: Lancet Glob Health. 2016 January ; 4(1): e57–e68. doi:10.1016/S2214-109X(15)00215-6.
Mortality and its risk factors in Malawian children admitted to hospital with clinical pneumonia, 2001–12: a retrospective observational study
Author Manuscript
Marzia Lazzerini, PhD, WHO Collaborating Centre for Maternal and Child Health, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy Nadine Seward, PhD, Institute for Global Health, University College London, London, UK Norman Lufesi, MPhil, Acute Respiratory Infection Control Programme, Community Health Sciences Unit, Lilongwe, Malawi Rosina Banda, BScNE, Parent and Child Health Initiative (PACHI), Lilongwe, Malawi Sophie Sinyeka, MSc, Parent and Child Health Initiative (PACHI), Lilongwe, Malawi
Author Manuscript
Gibson Masache, MSc, Parent and Child Health Initiative (PACHI), Lilongwe, Malawi Bejoy Nambiar, MPH, Institute for Global Health, University College London, London, UK Charles Makwenda, MSc, Parent and Child Health Initiative (PACHI), Lilongwe, Malawi Anthony Costello, FMedSci [Prof.], Institute for Global Health, University College London, London, UK Eric D McCollum, MD, and Institute for Global Health, University College London, London, UK
Author Manuscript
Correspondence to: Dr Tim Colbourn, Institute for Global Health, University College London, London WC1N 1EH, UK, [email protected]. Dr M Lazzerini, WHO Collaborating Centre for Maternal and Child Health, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34137, Trieste, Italy, [email protected]. Contributors ML designed this study with major inputs from NL, TC, NS, GM, BN, and AC. ML, NL, RB, SS, GM, and CM were involved in data collection in Malawi. NS was responsible for data cleaning, which was checked by TC. ML and NS did the descriptive and univariable mortality analyses, NS did the multivariable and multiple imputation analyses, and TC checked all analyses. ML wrote the first draft of the Article, with major contributions from TC, AC, NL, BN, NS, and EDM. All authors reviewed subsequent drafts and agreed on the final version of this paper. Declaration of interests We declare no competing interests.
Lazzerini et al.
Page 2
Author Manuscript
Johns Hopkins School of Medicine, Department of Pediatrics, Division of Pulmonology, Baltimore, MD, USA Tim Colbourn, PhD Institute for Global Health, University College London, London, UK
Summary Background—Few studies have reported long-term data on mortality rates for children admitted to hospital with pneumonia in Africa. We examined trends in case fatality rates for all-cause clinical pneumonia and its risk factors in Malawian children between 2001 and 2012.
Author Manuscript
Methods—Individual patient data for children (
