Mouse chromosome 17.

Mammalian Genome 3: $241-$260, 1992

=enome 9 Spfinger-VerlagNewYorkInc. 1992

Mouse Chromosome 17 Lee M. Silver, l'* Karen Artzt, 2 Denise Barlow, 3 Kirsten Fischer-Lindahl, 4 Mary F. Lyon, s Jan Klein, 6 and Linda Snyder 1 1Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544-1014, USA; 2Department of Zoology, The University of Texas at Austin, Austin, Texas 78712-1064, USA; 3Research Institute for Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria; 4Howard Hughes Medical Institute, University of Texas Southwestern, 5323 Harry Hines Boulevard, Dallas, Texas 75235-9050, USA; SMRC Radiobiology Unit, Harwell, Didcot, Oxon, UK; 6Abteilung Immungenetik, Max-Planck-Institut for Biologie, Corrensstrasse 42, 7400-Tfibingen, FRG

Received May 1, 1992

This is the third report from the Committee for Mouse Chromosome (Chr) 17. The report is organized as three tables and one figure. Table 1 is a master list of all loci currently and previously assigned to Chr 17 along with all symbols currently and previously used to distinguish these loci. This table contains 525 listings, including 200 that are considered " n e w . " This list includes a total of 311 apparently independent loci that have been mapped to specific sites along the 45 cM linkage group associated with Chr 17. This represents an average map density of 6.9 markers per cM and a 29% increase over the 241 mapped loci listed only one year ago in the second report. Mapped loci are listed in Table 2 according to their distance from the centromere in an order considered to be most likely at the present time. The extent of deletions, duplications, and inversions associated with variant Chr 17s is overlaid onto this "chromosome map." An additional 79 loci have been mapped more crudely to the chromosome, with 21 in the proximal half, 6 in the distal half, 32 in the vicinity of H-2, and 20 not mapped to a specific subchromosomal region. Of the 390 independent loci that have been mapped to the chromosome, 170 are defined only at the DNA level; another 39 represent genes that have not yet been cloned but have defined products or biochemical

*Chair of Committee for Mouse Chromosome 17

effects; and 118 represent cloned genes with known products (indicated by a "BD"). A total of 62 genes have been identified based on mutational effect on phenotype. Of these, one is also defined at the biochemical level, and four are also defined at the level of DNA clones. It is a striking statistic that only four mutationally defined Chr 17 loci have been cloned definitively, although cloned candidates have been described for a number of others including Tcd-! (Lader et al. 1989); Tcd-3 (Rappold et al. 1987); Tcd-4 (WiUison et al. 1986); Tcr (Schimenti et al. 1988); and Tme (Barlow 1991). Over the last year, a full appreciation has developed for the role that simple sequence repeat (SSR) loci can play in conjunction with PCR as tools for conducting classical linkage analysis in mammals. SSR loci are ideal mapping tools for three reasons. First, two short stretches of published sequence information are sufficient for an investigator to develop the reagents necessary to utilize any SSR locus as a marker for linkage analysis in a new cross. Second, most SSR loci are extremely polymorphic and thus much more useful than traditional RFLP loci for intra-specific mapping. Finally, PCR protocols for typing SSR loci are rapid and less labor-intensive than those required for RFLP analysis. For all of these reasons, SSR loci have quickly become the anchor loci of choice for most mapping studies. Table 3 represents a map of currently characterized Chr 17 SSR loci along with the primer sequences needed for their analysis. In addition, the relative positions of more traditional Chr 17 anchor loci are also indicated.

L . M . Silver et al.: M o u s e Chr 17

$242 Table 1. Locus list for mouse Chr 17. New Locus

* * *

*

*

4.24A" 424F" 6-3-8-P1 Aa Ab

Aery-I Ads-I Ads.3 Agp-I Agp-3 B144 Bat-1 Bat-2 Bat-3

Bat-4 *

Bat-5 Bat-6 Bat-7 Bat-8

Bat-9 *

Bemv-I

B/ Bkm-1 Bkm-2 C2 C3 C4

c4stp

*

Cbs Cdc-2b Ce-2 Ck-2 eld Col l l a2 Cps-1 Crl-I Crya. l Csi Csp-1 Cxv-1 Cyp21 Cyp21-ps

*

D

*

DI, D2, etc. D I 6S259h D17Au 31 D17Au 31t DI7Au 7 DITAu 9 DI7Au 10 DI7Au 16 DI7Au 17 D17Au 31 D17Au49 DI7Au53 D17Au57 DI7Au64 D17Au 76 D17Au100 DI7AulI6 D17AulI9 D17Au126 D17Au127 DI7Au144 DI7Au2171 DI7Au21711 DI 7Her139 Dl7HerlgO DI 7Ken1 D17L~h 9 D17Leh 12 D17Leh 18 D17Leh 23 D17Leh 26

* * * * * * * * * * * * * * * * * *

*

C-ene name (trenseribed sequence 4.24A) (transcribed sequence 4.24F) see D17bts638Pl" see H-ZAa see H-2Ab see Crya- 1 Anti-dsDNA antibody Anti-dsDNA antibody-3 Anti-gp70 immune complex- 1 Anti-gp70 immune complex-3 sec D17Slkl HLA-B-associated transcript-1 HI.A-B-associated trenseript-2 HI.A-B-associated transcript-3 HI,A-B-associated transcript-4 HLA-B-assoeiated transer/pt-5 HLA-B-associaled transcript-6 HLA-B-associated transcript-7 HLA-B-associateA transcript-8 HLA-B-associated transcript-9 B26-1ike endogenous routine vires Complement component factor B Banded krait minor satellite- 1 Banded krait minor satellite-2 Complement component-2 Complement component-3 Complement component-4 Complement eornpon ent-4 Cystathione beta synthase Cell division cycle control protein-2b Kidney eatalase-2 Creatine kinase-2 Combined lipase deficiency Collagen-ll alpha-2

T BD BD

M (eM) Method H. s~n'abol H. location Reference 27 P 18.54 27 18.55 P

B B B B

H-2 H-2 H-2 H-2

BD BD BD BD BD

19.08 19.02 19.03 19.01 19.00 BD 18.99 BD 18.90 BD 18.87 BD 18.88 D 15.15 BD 18.85

99 99 74, 120 74, 120

L L L L

BAT8 BAT9

6p21.3 6p21.3 6p21.3 6p21.3 6p21.3 6p21.3 6p21.3 6p21.3 6p21.3

BF

6p21.3

C2 C3 C4

6p21.3 19p 6p21.3

CBS

21q22.3

COL11A1

6p21.3

LPIR L L L

CRYA1

21q22.3

P P P P

P P L P

P P P I

BAT1 BAT2 BAT3 BAT4 BAT5 BAT6 BAT'/

14, 173, 209 14 14, 23 14 14 174 14 14 14 210 150 90 90 50, 184 33, 133 35, 163 139, 140 131 86 75 26, 41 141 67

D

P

D BD BD BD BD BD BD B BD VB BD

D 18.86 32.20 18.80 18.83 17.40 ? 24.80 23.90 11.60 18.50

I

B BD B BD B BD D

H-2 17.40 H-2 18.98 16.50 18.77 18.81

L

P P

CYP21P CYP21A1

6p21.3 6p21.3

D D D D D D D D D D D D

P

D16S259

16p13.3

D D D D D

12.00 3.10 3.60 14.80 2.00 7.30 15.14 9.40 9.40 9.40 9.40 15.14 17.70 8.38 15.14 0.50 7.20 11.70 17.90 9.40 3.15 3.60 3.80 3.85

DT LT DT DT T T T T T T LT DP T DT DT LT LT T T DT P P

72 76 76 45 76 46 45 45 45 45 45 45 45 46 45 46 46 45 45 45 46 46 70 70

D D D D D

9.01 12.00 20.50 24.20 16.40

L DPR LT LR LR

7, 132 7,132 164 132 132

P LI P P LP L L L L P

see Dep-2 Complement receptor lymphocyte- 1 Alpha erystallin-1 Corticosteroid side-chain-isomerase Cleft palate susceptibility-1 Centrol of xenotropic virus- 1 Cytoehrome P450, 21 Cytoehreme P450, 21, pseudogene see H-2D see Ted-l, Ted-2, etc. DNA segment, single copy, probe pGGG1 DNA segment Austin 31 DNA segment Austin 3II DNA segment Austin 7 DNA segment Austin 9 DNA segment Austin I0 DNA segment Austin 16 DNA segment Austin t7 DNA segment Austin 31 DNA segment Austin 49 DNA segment Austin 53 DNA segment Austin 57 DNA segment Austin 64 DNA segment Austin 76 DNA segment Austin 100 DNA segment Austin 116 DNA segment Austin 119 DNA segment Austin 126 DNA segment Austin 127 DNA segment Austin 144 DNA segment Austin 217I DNA segment Austin 217II DNA segment Hen'mann 139 DNA segment Herrmann 190 see Tep-11 DNA segment Lehrach 9 DNA segment Lehrach 12 DNA segment Lehrach 18 DNA segment Lehrach 23 DNA segment Lehrach 26

D

D D D D

D D

L

64 172, 181 197 63, 173 211 203 203

Continued on next page

L . M , S i l v e r e t al.: M o u s e C h r 17

$243

Table 1. Continued. New Locus Dl7l.~h 27 DI 7I.~h 48

* * *

*

* * * * * * * * * * * * * * * * * * * * * * * * * * *

*

D17Leh54 D17Leh55 D17Leh 66A D l 7 L e h 66B D17Leh 66C Dl7Leh 66Dbl D l 7 L e h 66Db2 D17Leh 66Dgl DlTLeh 66Dg2 Dl7Leh 66Dg3 D17Leh 66EI D17Leh 66E11 D I 7Leh 80 D17Leh 89 D17Leh 94 DI7LehlOSA D17LehlOSB Dl7Lehlll DI 7 L e h l l 6 DlTLeh117c D17Leh1191 D17Leh11911 Dt7Leht22 DI 7Leh145 D17Leh154 D17Leh171 D17Leh173 D171.~h180 D17Leh236 D17Leh443 D17Leh467 D17L~h508 DI 7Leh525 DI 7Leh550 D17MIT1 DI7MIT 2 DI7MIT3 DI7MIT4 DI 7 M I T 5 DI7MIT 6 DI7MIT 7 D I 7MIT 8 D17MIT 9 D17MIT10 DI7MITI1 D17MITI3 DI7MITI6 DI7MITI8 D17MIT19 D17MIT20 D17MrF21 D17MIT22 D17MIT23 DI7MFI24 DI7Ms225P2" D17Ms638PI" D17Ms8"29P2" D17Ms836P2" DI 7Nds2 DI7Nds3 DI7RplO D17Rp11 DITRp17 D17Slkl DI 7Tu I D17Tu 2 D I 7Tu 3 D t 7Tu 4 D I 7Tu 5 D17Tu 6 D17Tu 7 DI7Tu8

G-ene name DNA segment Lehraeh 27 DNA segment Lehraeh 48 DNA segment Lehraeh 54 DNA segment Lehrach 55 see Tep-lOa see Tep-10b ser Tep-10e DNA segmentLehrach 66D-bl DNA ~ g m c m L e h r a e h 66D-b2 DNA segraent Lekarach 66D-gl DNA segment Lehrach 66D-g2 DNA segment Lehraeh 66D-g3 DNA segment Lehrach 66EI DNA segment Lehraeh 66EII DNA segment Lehrach 80 DNA segment Lehrach 89 DNA segment Lehrach 94 DNA segment Lehrach 108 DNA segment Lehraeh 108 DNA segment Lehraeh 111 DNA segment Lehrach 116 see Tete-3 DNA segment Lehrach 1191 DNA segment Lehrach 11911 DNA segment Lehrach 122 DNA segment Lehrach 145 DNA segment Le,hrach 154 DNA segment Lehrach 171 DNA segment Lehrach 173 DNA segment Lehrach 180 DNA segment Lehrach 236 DNA segment l.xhrach 443 DNA segment Lehrach 467 DNA segment Lehrach 508 DNA segment Lehrach 525 DNA segment Lehrach 550 DNAsegmentMIT 1 (on 17?) D N A segment M r r 2 (on 17?) DNA segment M r r 3 (microsateilite) DNA segment MIT 4 (mierosatellite) DNA segment MIT 5 (microsatellite) DNA segment M r r 6 (mierosatellite) DNA segment MIT 7 (microsateilite) DNA segment M r r 8 (microsatellite) DNA segment MIT 9 (microsatellhe) DNA segment MIT10 (microsatellite) DNA segment M r r l 1 (microsatellite) DNA segment M r r l 3 (mierosateUlte) DNA segment M r r l 6 (microsatellite) DNA segment MIT18 (microsatellite) DNA segment MIT19 (microsatellite) see C3 see H-2Ab see H-2Eb2 sen Pim-i see H-2M2 MinisateUite 2-2-5-P2 Minisatellite 6-3-8-P1 Minlsatellite 8-2-9-P2 Minisatellite 8-3-6-P2 see Hsp70 see Tnfb see Hprt-~ 1 DNA segment Roswell Park 11 DNA segment Roswell Park 17 B-cell expressed 144 DNA segment Ttibingen 1 DNA segment Tiibingen 2 DNA segment Tiibingen 3 DNA segment Tilbin gen 4 DNA segment Ttibingen 5 not on Chr 17 not on Chr 17 not on Chr 17

T D D D D

M (cM~ 23.90 1.00 10.51 9.75

Method H. symbol H. location Reference L 132 DLPT 8, 57 DLPR 20 LP 7

D D D D D D D D D D D D D D

8.75 8.85 8,65 8.78 8.9O 3.30 3.40 9.50 20.50 10.00 20.16 20.17 9.75 23.90

PT PT DPT FI" PT

D D D D D D D D D D D D D D D D D D D D D D D D D D D D D

3,07 3.70 9.95 ? 23.90 20.13 21.80 10.90 ? 10.50 20.50 7.60 20.50 9.90 D D 45,00 32.(30 32.00 23.90 23.50 23.50 23.70 23.90 23.35 18.75 18.30 4.00 1.50

PR DPT PT S LR L LR LR S DLPR LT P LRT LR L L LR L L LR LR LR L LR LR LR LR L L

69 69 57 148 132 132 132 20 148 20 20 7 20 132 37 37 37 37 37 37 37 37 37 37 37, 37, 37, 37, 37

D D D D

17.45 21.55 15.40 15.40

L L L L

85 85 85 85

BD BD BD D D D D D

27.00 7.50 19,04 0.50 18,91 18.91 18.91 3.72

L DLRP P DT L L L L

117 55,91,118 188 73, 196 196 196 196 196 160 160 160

PR

DP T LRT

DLPR L L LFI'R LR

D6S131

157 157 69, 157 157 157 69 69 164 6p21.3-22.1 20 20 57 57 7, 132 132

103 103 103 103

Continued on next p a g e

L.M. Silver et al.: Mouse Chr 17

$244 Table 1. Continued. New Locus DI 7Tu 9 D17TulO D I 7Tul l DI 7 T u 1 2 DI7TuI3 DI 7Tu14 DITT~5 DI7TuI6 DI 7Tul 7 DITTul8 DI7TuI9 DITTu20 DITTu,21 D17 Tu22 D17Tu23 DITTu24 D17Tu25 D17Tu26 D17Tu27 D I 7Tu,28 DI7T.29 DI7Tu30 D17Tu31 D 17Tu32 DI 7Tu33 D 17TId4 D 17Tu35 DI7Tu36 DI7Tu37 DI7Tu38 D17Tu39 D I 7Tu40 D I 7Tu41 D I 7Tu42 D17Tu43 D17Tu44 D17Tu45 D17Tu46 D17Tu47 D17Tu48 DITTu49 DI7TuSO D17Tu51 D17Tu52 D17Tu53A D I 7Tu5 3B DITWas70 * D2 D21S56h * D3 * 134 * D6S81Eh Dcp-1 Dcp-2 * Dna *

Ea

*

Eb

*

Eb2 Fu Ggm-1 Glo-1 Gnat-2 grr H-2Aa H-2Ab H-2D H-2D2 H-2D3 H-2D4 H-2Ea H-2Ebl H-2Eb2 H-2K H-2K2

*

C-~nenmme D N A segment Ttlbingen 9 D N A se~nent Ttibingen 10 not on Chr 17 not on Chr 17 not on Oar 17

T D D

? 14.70

M (eM) Method H. s~'mbol H. location Reference L

DNA segment Ttlbingen 14 not on Oar 17 DNA segrnent Tfibingen 16 not on Chr 17 DNA segment Ttlbingen 18 DNA segment Tnbingen 19 DNA segment Ttibingen 20 DNA segment TUbingen 21 DNA segment Tttbingen 22 DNA segment Tttbingen 23 DNA segment Ttibingen 24 DNA segment Tiibingen 25 D N A segment Ttibingen 26 DNA segment Ttibingen 27 DNA segment Tfibingen 28 DNA segment Tlibingen 29 DNA segment Tiibingen 30 not on Chr 17 DNA segment Tiibingen 32 DNA segment Tiibingen 33 DNA segment Tiibingen 34 DNA segment Ttibingen 35 DNA segment Tiibingen 36 D N A segment Ttibingen 37 DNA segment Tiibingen 38 DNA segment Ttibingen 39 DNA segment Tfibingen 40 DNA segment Ttibingen 41 DNA segment Tiibingen 42 DNA segment Ttibingen 43 not on Chr 17 DNA segment Ttibingen 45 not on Chr 17 DNA segment Tiibingen 47 DNA segment Tiibingen 48 DNA segment Tiibingen 49 DNA segment Ttibingen 50 not on Chr 17 DNA segment Tiibingen 52 DNA segment Tfibingen 53A DNA segment Tfibingen 53B DNA segment Washington 70 see H-2D2 DNA segment human D21S56 see H-2D3 see H-2D4 See Bat- 1 Dexamethasone-induced cleft palate- 1 Dexamethasone-induced cleft palate-2 see H-2Na see H-2Ea see H-2Ebl see H-2Eb2 Fused Ganglioside expression- 1 Glyoxalase- 1 Not on ehr 17 Growth and reproduction complex I-IistOCOl"n)atibility-2 class II locus Aa Histocom )atibility-2 class II locus Ab Histoeom )atibility-2 etass I locus D I-Iistocom )atibility-2 class I locus D2 Histocom >afibility-2claasIlocusD3 HJstocom )atibility-2elassllocusD4 Histocom )atibility-2 class II locus Ea Histocom )atibility-2 class II locus Eb Histoeom )atibility-2 class II locus Eb2 Histocora )atibility-2 class 1 locus K ttistocom )atibility-2 class I locus K2

D

21.80

L

D

22.80

LR

D D D D D D D D D D D D D

? 20.40 28.50 ? ? 32.00 20.20 9.50 23.00 28.10 ? 7 9.25

L L S S L L L L L S S SLR

D D D D D D D D D D D D

20.20 9.25 6.90 ? 10.52 23.00 ? ? 27.20 ? 20.20 9.50

L SLR L S L L S S L S L LP

D

?

S

D D D D

? ? 20.50 9.51

S S LRT LP

D D D D

3.02 3.00 3.73 0.00

L PT FI" I

D

17.20

LR

V V

0.00 H-2 H-2

L L

16 16

V B

11.80 17.50

B

16.00

DL L L

BD BD BD BD BD BD BD BD BD BD BD BD

19.82 18.65 18.64 19.09 19.10 19.11 19.12 18.70 18.66 18.67 18.44 18.43

L P PLR P P P P P P PLR LP LP

146 68, 152 39, 126 94 195 93, 96 93, 96 93, 96 96, 180 96, 180 96, 180 93, 96 93, 96 37, 93, 96 93, 96 93, 96

196 196 160 160 160 160, 196 160 196 160 196 196 196 196 196 160 196 160 196 160 196 196 160 160 196 196 160, 196 196 160 160 196 196 196 196 160, 196 160 160 196 160 196 196 196 160 160 196 175, 196 175, 196 38

S

S

D21S56

21q22.3

GL01

6p21.2-.3

DQAI DQB1 HLA

6p21.3 6p21.3 6p21.3

DRA DRBI DRB2 HLA HLA

6p21.3 6p21.3 6p21.3 6p21.3

24


L.M. Silver et al.: M o u s e C h r 17

$245

Table 1. Continued. New Locus * *

*

*

* * *

*

*

*

H-2Kel H-2Ke2 H-2Ke3 H-2Ke4 H-2Ke5 H-2L H-2M1 H-2M2 H-2M3 H-2M4 H-2M5 H-2M6 H-2M7 H-2M8 H-2Ma H-2Mbl H-2Mb2 H.2Na H-20b H-2Pb H-2Q 1 H-2Q2 H-2Q4 H.2Q5 H.2Q 6 H.2Q 7 H-2Q 8 H.2Q 9 H-2QIO H-2T 1 H-2T2 H-2T 3 H-2T4 H-2T5 H-2T 6 H-2T 7 H-2T8 H-2T9 H-2TIO H-2Ttt H-2T12 H-2TI3 H-2T14 H-2T15 H-2T16 H-2T17 H-2TI8 H-2T19 H-2T20 H-2T21 H-2T22 H-2T23 H-2T24 H-2Tlev 1t-31 1t-32 H-33 H-43 Ham-1 Ham-2 Hba-ps4 her Hh.l Hkrl-rsl7'" Hint Hom.l Hprt-ps l Hprt-ps2 Hsc70t

Hsp68 Hsp70

Hsp84 Hst-1 Hst-4

Gone name K-region expressed- 1 K-region expressed-2 see RI:~ lg K-region expressed-4 K-region expressed-5 Histoeompatibility-2 class I locus L l-listoeompatibility-2class 1 locus M1 Histoonmpatibility-2class I locus M2 Histocompatibility-2 class I locus M3 HistocompafibiJity-2 class I locus M4 I-Iistocompatibility-2class I locus M5 Histocompatibility-2class I locus M6 Histocompatibility-2class I locus M7 l-liatocompatibility-2class I locus M8 Hiatocompatibility-1 class 1I Ma Histocompatibility-1 class II Mbl Histocompatibility-1 class II Mb2 Histocompatibility-2 class II locus Na Histocompatibility-2 class II locus Ob Histocompatibility-2class II locus Pb Histocompatibility-2 class I locus Q 1 Histoe~vnpatibility-2class I locus Q2 Histocompatibility-2 class I locus Q4 Hiatocompatibility-2 class I locus Q5 Histocompatibility-2 class I locus Q6 Histocompatibility-2 class I locus Q7 Histocompatibility-2 class I locus Q8 HistocompatibilJty-2 class I locus Q9 Histoccxnpatibility-2class I locus Q10 ttistocompatibility-2 class I locus T 1 Histocompatibility-2 class I locus T 2 tiistocompatibility-2class I locus T 3 I-listocompatibility-2class I locus T 4 Histocompatibility-2 class I locus T 5 Histocompatibility-2 class I locus T 6 ttistocompatibility-2 class I locus T 7 Histocompatibility-2 class I locus T 8 Histocompatibility-2 class I locus T 9 Histocompatibility-2 class I locus T 10 HistocompatibiJity-2 class I locus T 11 I-Iistocompatlbility-2class I locus T 12 I-listocompatibility-2class I locus T 13 Histocompatibility-2 class I locus T 14 Histocompatibility-2 class I locus T 15 I-Iistocompatibility-2class I locus T 16 Histocompatibility-2class I locus T 17 Histocompatibility-2 class I locus T 18 Histocompatibility-2 class I locus T 19 Histocompatibility-2 class I locus T 20 Histocompatibitity-2 class I locus T 21 Histocompatibility-2 class 1 locus T 22 Histocompatibflity-2 classI locus T 23 Histocompatibility-2 class I locus T 24 I-I-21"14region endogenous virus I-Iistoc~'apatibility-31 Histoenmpatibility-32 Histocompatibility-33 Histocompatibility-43 sec Tap-1 see Tap-2 Hemoglobulin alpha-pseudogene 4 Head-tilt Hemopoietic histocompatibility-1 Human kmppel- 1 related sequence see H-2M3 Androgenic hormone- 1 HPRT psoudogene- 1 see Hprt-ps 1 Heat shock protein 70 (constitutive) see Hsp70 Heat shock protein 70 Heat shock protein 84 Hybrid sterility-1 Hybrid sterility-4

T BD BD

M (cM) Method H. symbol H. location Reference 18.40 P 1,210 18.41 P 1,210

BD 18.48 BD 18.49 BD 19.13 D 20.27 BD 20A4 BD 20.45 D 20.32 D 20.33 D 20.31 D 20.28 D 20.30 BD 18.56 BD 18.58 BD 18.57 BD 18.52 BD 18.63 BD 18.51 D 19.14 D 19.15 BD 19.16 D 19.17 D t 9.18 BD 19.19 BD 19.20 BD 19.21 BD 19.22 D 20.05 D 20.04 BD 20.03 D 20.02 D 20.01 D 20.00 D 19.99 BD 19.98 D 19.97 BD 19.96 BD 19.95 BD 19.92 BD 19.91 D 19.90 BD 19.89 D 19.80 D 19.79 BD 19.78 D 19.77 BD 19.76 D 19.75 BD 19.74 BD 19.73 BD 19.72 D 19.82 B 1{-2 B H-2 B P B ?

P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P L P L L L L

D V B D

12.00 4.10 19.09 10.52

DLPR L L D

B D

H-2 35.00

82, 83 77

BD

18.95

122

BD BD V V

18.94 27.50 8.81 14.90

P P P LP

RING5 KE5

6p21.3 6p21.3

DMA DMB DMB DNA DOB DPB

6p21.3 6p21.3 6p21.3 6p21.3 6p21.3 6p21.3

PLRT LT P P LP P P

PLR

L L L

19?

HSPA1

6p21.3

1,177 1 93,96 96,168 18,37,96 9~ 147,198 52, 96 5Z 96 5 2 96 5Z 96 52, 96 27,28,88 27,28,88 27,28,88 67 93, 96, 178 67,93,96,178 124, 125,171,176,179,202 124, 125,171,176,179,202 124, 125,171,176,179,202 124, 125,171,176,179,202 124, 125,171,176,179,202 124, 125,171,176,179,202 124, 125,171,176,179,202 124, 125,171,176,179,202 124, 125,171,176,179,202 96, 179, 202 96,179,202 96, 179,202 96,179,202 96, 179, 202 96,179,202 96,179, 202 96,179,202 96,179, 202 96, 179,202 96, 179,202 19, 96, 179,202 19,96, 179,202 19, 137 19,96, I79,202 96,179, 202 96, 179, 202 96,179,202 96,179, 202 96,179, 202 96,179, 202 81,96,179,202 96, 104, 179,202 96, 179, 202 137 54 54 53 78-80

32,56 182 14,31,173 10,155

37, 62, 173, 174 129, 149 55 143 Continued on next page

$246


Table 1. Continued. New Locus Hye * la ldd-I 1fi-15 lg/2r lnt-3 It-5 *

K

*

*

/(.2 Ke-I Ke-2 Ke-3 Ke-4 Ke-5 Kth-1 L 1(17). 2Pas 1(17)- 3Wis l(17)- 4Wis l(17). 5Wia l(l 7)- 6Wis 1(17)- TW/s l(17). 8Wis l(l 7)- 9Wis l(17)-lOWis l(17)-11Wis Lama Lbt-I Lmp-2 Lmp- 7 Lpn-I Lpa-I Lpn-3 Ltx Ly.39 M1

*

M2

*

M3

*

M4

*

M5

*

M6

*

M7

*

3t8 Mas Mbl Mdgm.1 Mep-1 Ms15-3 Ms2.2-5-P2 Ms8-3.6.P2 MsS-5-9-P2 Mug Nel-I Neu-I Nfya NTfin12 Ob Oct- 4 Odc-rsl5 0h21-1 0h21-2 Oreh-1

*

*

* *

* * * *

* *

* * *

* *

or *

*

Ot.f3-rs7 Pb Ped Pgk-2 Pim-I

mg *

Pray-57

*

Q1

*

Q2

*

Q4

*

Q5

G-,eriename H-Y expression ~ H-2E and H-2A loci Insulin dependent diabetes- 1 Intexferon-indueexl-15K Insulin-like growth factor-2 receptor Mammary mmorintegration site-3 Immune rr ~ H-2.K see H-2K2 see H-2Kel see H-2Ke2 see Rps 18 see H-2Ko4 see H-2Ke5 Kidney 40-50 thousand Mr protein- 1 see H-2L Chr 17 lethal-2Pas Chr 17 leaiaal-3WLs Chr 17 lethal-4Wis Chr 17 lethal-5Wis Chr 17 lethal-6Wis Chr 17 leahal-7Wis Chr 17 leshal-gWis Chr 17 lethal-9Wis Chr 17 lethal-10Wis Chr 17 lethal-1 lWis Laminin A (on 177) Lupus band test-1 Low molecular mass polypeptide-2 Low molecular mass polypeptide-7 NZ lupus nephritis- 1 see Ads- 1, Agp- 1 see Ads-3, Agp-3 see Tnfb Lymphocyte antigen-39 see H-2MI see H-2M2 see H-2M3 see H-2M4 see H-2M5 see H-2M6 see H-2M7 see H-2M8 mas oncogene see H-2M 1 Mandibular morphogenesis- 1 Meprin - 1 Minisatellite 15-3 see D17Ms225P2" see D 17Ms836P2" see D17Ms829P2" L-Methylmaltmyl-CoA mutase Nel lymphocyte antigen-1 Neurarninidase- 1 Nuclear factor-Y, subunit A Zinc fmger 12 see H-2Ob see Otf-3g Omithine dexarboxylase-rel.seq.15 see Cyp21 see Cyp21-ps Autoimmune orchitls resistance sex Otf3-rs7 Oetames binding protein family-3 tel. seq. see H-2Pb see H-2Q7 Phosphoglyeerate kinase-2 Proviral integration site, MCF Plasminogen Polytropic routine virus see H-2Q 1 see H-2Q 2 seeH-2Q 4 ~e H-2Q5

T B

M (cM) Method H. symbol H. location Reference P L 100

V BD BD BD B

H-2 22.50 8.35 18.73 37.10

L L DP L L

B

H-2

L

48

V V V V V V V V V V BD B B B B

9.02 P P P P P P D P H-2 D H-2 18.59 18.62 ?

L L L L L L L L L L R L L L L

92 161 161 161 161 161 161 161 161 161 49 60 119, 128 119, 128 98

B

?

L

BD

8.45

DLP

V B D

P 24.60 21.80

L L LR

BD B B BD BD

22.50 H-2 18.93 23.90 10.52

LI L L LI RDT

D

15.00

L

169

VBD 18.98

L

173,174, 185

19.23

L

189

20.80 16.40 8.15 17.00

L LR DP LR

7 BD

BD VBD BD D

IGF2R

6q26-q27

L4MA

18pl 1.2-.3

RING12 R1NGIO

6p21.3 6p21.3

144 29, 159 9, 105 170 212

138

MAS

6q24-q27

22 6 15, 145 84

MOT

6p12-21.1

NEU

6p21.3 6p21.1

PGK2 PIM PLG

6p11-21.1 6pl 1-21.1 6q26-q27

106, 186 71 51, 142, 208 108 135

47, 193, 194 4, 37 9, 13, 158 58



$247

Table 1, Continued. New Locus

~0

*

Q6

*

Q7

*

Q 819

*

*

QIO Qa-2

*

Qb-1 Qa, n

see H-2Q 6 soc H-2Q 7 see H-2Q 8/9 soe H-2Q10 see H-2Q7, H-2QS, H-2Q9 see H-2Q4 Qa- 1 determinant modifier

qk

Quaking

R

see Tcr Ras-like-2-1 Ras-like-2-3 Ras-like-3 Ras-likr Repented dipepdde Retinal degtmeration slow Recovery from Friend virus- 1 Recovery from Friend virus-2 Recovery from Gress virus- 1 Recognition of identity- 1 Recognition of identity-2 Regulation of Igh- 1b- 1 (to be named) see Tap-2 (to be named) (to be named) see Ham-1 sen Tap- 1 Resistance to Moloney virus-1 Resistance to Moloney virus-2 Resistance to Moloney virus-3 U14 small nuclear RNA Ribosomal protein S 13 Resistance to Rous sarcoma Resistance to radiation leukemia virus- 1 Sperm-coating glycoprotein Scopolamine modification of expl. activ. Serum gp70 production- 1 see D17SIkl see C4SIp Superoxide dismutase-2 (mitochondrial) see C4 Brachyury (short tall) see H-2T 1 see H-2T 2 see H-2T 4 see H-2T 5 sen H-2T 6 see H-2T 7 see H-2T 8 see H-2T 9 see H-2T10 see H - 2 T l l see H-2T16 see H-2T17 see H-2T18 see H-2T19 see H-2T20 see H-2T21 see H-2T22 see H-2T23 see H-2T24 see Tcp-10a see Tcp-10b see Tcp- 10c see D 17Leh66Dg 1,b 1,g2,b2,g3 see D 17Leh 66EI see D17Leh 66EII Histocompatibility antigen modifier-1 Histocompatibility antigen modifier-1 T-associated sex reversal t complex distorter- 1 t complex distorter-2 t complex distorter-3 t complex distorter-4

*

R asl2 -1 Rasl2 -3 Rasl3 Rasl3 Rd rds R#-I

* *

*

Rfv.2 Rgv.l Ri.1 Ri-2 Rig-1 Ringl" RING 11 Ring2" Ring3" Ring4 RING4 Rmv-1 Rmv-2 Rmv- 3 Rnul4 Rps18 Rr$ Rrv-1 Scg Sco Sgp-I Slk-1

Sip

*

Sod-2 Ss T TI

*

T2

*

T4

*

T5

*

*

T6

*

T7

*

T8

*

T9

*

TIO

*

TI1

*

T16

*

T17

*

T18

*

TI9 720 721 722 723 724 T66A T66B T66C T66D T66EI T66EII Tap.l Tap -2 To* Tcd-1 Ted-2 Ted-3 Ted-4

* *

* * * * * * * * *

n a~TIC

T

M (cM) Method H. sItmbol H. location Reference

B V

H-2 7.20

L DL

2 91

D D D D BD VBD V V V B B B BD

? 33.50 14.70 D 18.84 24.95 H-2 H-2 H-2 H-2 H-2 H-2 18.46

L L L L LP L L L L L L L P

BD BD

18.47 18.53

P P

V V V D BD V V BD V B

H-2 H-2 H-2 18.95 18.42 H-2 H-2 21.05 H-2 H-2

L L L P P L L L L L

BD

8.60

DP

VBD 3.87

DLP

BD BD V V V V V

P P D T T T T

18.60 18.61 6.03 2.00 16.85 9.93 8.38

RD RDS

6p21.3 6pi2

RINGI

6p21.3

41 41 41 41 107 36, 187, 192 25 25 109, 110 3 3 40 66,67

RING2 RING3

6p21.3 6p21.3

66, 67 66, 67

KE3

6p21.3

SOD2

6q21

34 34 34 111 1,115 2O4 112 95 136 121

70

TAP1 TAP2

6p21.3 6p21.3

127 127 199, 200 114 114 114 166 Continued on next page

$248


Table 1. Continued. New Locus Ted-3 tel- 0 *

*

*

* * * *

*

*

*

* * * * *

*

tel- 4

tel-12 tel.Lubl tet-Lub9 tel-Pal tel-T~ 2 tel.Tuw l l tel-Tin,,12 tcl.T~20 tcl-Tuw24 tel-Tuw25 tel-Tuw27 tel-Tuw28 tel-w 1 tel-w 5 tel-w12 tel-w18 tel-w73 Tcp- 1 Tcp- l x Tcp- 2 Tcp- 3 Tcp-4 Top- 5 Tcp-6 Tcp- 7 Tcp- 8 Tcp- 9 Tcp- l Oa Top-lOb Tcp-l Oc Tcp- 11 Tcr tes- 1 tes-2 tcs-3 tcs-4 tcs-5 Tcte-I Tote-2 Tote-3 Tctex- 1 Telex- 2 Tetex- 3

Tctex- 4 Tctex- 5 Tctex- 6 Tctex. 7A Tctex- 7B Tctex. 8 Tctex- 9 Tctex-lO Tctex.ll Tctex-12 Tera-1

r *

Thbs-2

thf * * * *

Thy-19.4 Ttty-2 Thyt9 7"1-11 Tla Tier Tn~ Tnfa

r,# Tpx- 1 Tpx-2 Ts-I Ts-2 Tse

C_~ne

name

t complex di~orter-5 t complex leth~d-0 see tel-wl8 t eamplex lethal- 12 t exrnplex lethal-Lubl t complex lethal-Lub9 t c~naplex lethal-Pal t complex lethal-Tuw2 t complex lethal-Tuwl 1 t complex lothal-Tuwl2 t complex lethal-Tuw20 t complex lethal-Tuw24 t complex lethal-Tuw25 t complex lethal-Tuw27 t complex lethal-Tuw28 s~e tel-wl2 t complex lethal-w5 t complex lethal-wl2 t complex lethal-w 18 t complex lethal-w73 t complex protein- 1 t complex protein- lx see Pgk-2 t e~aplex protein-3 t complex protein-4 t complex protein-5 t complex prV,zin-6 t complex protein-7 t complex protein-8 t complex protein-9 t complex protein-10a t complex proteln-10b t complex protein- I0c t eomptex protein-11 t complex responder see Ted- 1 see Ted-2 see TOd-3

T V V

M(cN 0 Method H. s]nnbol H. location Referenee T 165 20.50 11.70 L 4

V V V V V V V V V V V V

19.83 20.20 P P P P P P P P P P

L L L L L L L L L L L L

5,43,162 206 205 65 97 97 97 97 97 97 97 97

V V V V BD BD

18.20 14.80 10.52 8.38 8.55 8.50

L L D D DLPIR TCPI PI

44 4 11 153 9, 13,204a 42

B B B B B B B BD BD BD BD V

15.90 2.00 2.00 15.90 15.90 2.00 2.00 3.35 8.70 8.80 14.35 8.70

T T T T T T T LTI LIP FFI TI LP

BD D BD BD

23.50 9.00 9.50 2.50

LIR P PT DT

BD BD BD BD BD BD BD BD BD BD BD BD V BD V

15.15 19.86 I9.86 I%86 18.38 15.15 18.37 18.36 18+35 18.34 15.15 9.52 13.30 9.80 35.30

P P P P P P P P P P P LP L LTI L

V BD BD BD BD V V D

8.35 19.05 I9.06 22.80 24.40 H-2 I-1-2 19.85

DP P P LR L L L L

TCPIO TCPIO TCPIO

6q26-q27

6q21~q27 6q27 6q21-q27

167 167 i67 t67 167 167 167 21, 12, 12, 123 12,

116 13, 156 156 151,175

see Ted-4 see Tcd-5

t complex testis expressed- I t complex testis expressed-2 t complex testis expressed-3 t complex testis expressed-1 see Tete-3 t complex testes expressed- 3 t complex testis expressed-4 t complex testis expressed-5 t complex testis expressed-6 t complex testes expressed- 7A t complex testes expressed- 7B t complex testes expressed- 8 t complex testes expressed- 9 t complex testes expressed-10 t complex testes expressed- 11 t complex testes expressed- 12 Teratoeareinoma- 1 tufted Thrombospondin-2 thin fur see 1t-2M2 Not on ehr 17 see H-2M2 see H-2Tll see H-2T18 see H-2Tlev T-associated maternal effect Tumor ne.~-~osisfactor alpha Tumor necrosis factor bela Testis protein x- 1 Testis protein x-2 Triehinella spiralis w.sistance-1 TrichineUa spira~ resistance-2 t haplotype-specific dement family

TCTE1

6p11-21.1 6q21-q27

THBS2

6q27

TNFA TNFB TPX1

6p21.3 6p21.3 6p11-21.1

12, 101,154 7 7, 144a 102 210 190 i90 I90 210 210 210 210 210 210 210 95 113 17 89

9, 207 61,130, 134 37, I30, I34 87 87 201 201 191 Continued on next page

$249

L . M . S i l v e r et al.: M o u s e C h r 17

Table 1. Continued. New Locus Upg-I Xmv-36 * Xmv.57 Zfa 8 *

Ge~e name Urinary pepsinogea-1 Xealotropic mutine lcuk~nia virus-36 Xc~otropic routine virus zinc fmgcx 8

T BD D D D

M (cM) 27.00 12.43 23.75 10.25

Zfa/2

zinc finger12

D

10.25

Zfal8 Zfa29

zinc finger 18 zinc finger 29

D D

10.25 10.25

Information provided and abbreviations used in each column are as follows. In the " N e w " column, an asterisk indicates that the locus listed here was not present in the master locus list of the last report from this committee. Quotation marks after the locus symbol indicates that the symbol is a provisional one which does not follow the rules set by the mouse nomenclature committee. In the " T " column, D = defined at the DNA level as a clone or sequence; B = defined at the level of the gene product or its effect (biochemical/protein/ immunological/transcript); and V = defined by a mutation that results in a "visible" phenotype. In the " M " column, a number indicates a known location on the genetic map (distance in cM from the centromere); the number

Method H. symbol H. location LR PGC 6p L LR DP DPRLT DP DPR

serves as a cross-reference to Table 2. " H - 2 " indicates the general mapping of the locus to the H-2 region. " P " indicates a general location proximal to H-2. " D " indicates a general location distal to H-2. " ? " indicates an undefined location on Chr 17. " M e t h o d " refers to the protocol(s) used to determine the subchromosomal location: I - in situ hybridization; S = somatic cell genetics; R = RI lines; L = linkage analysis; D = deletion analysis; P = physical mapping; and T = partial t haptotype mapping. " H . s y m b o l " refers to the symbol used to describe the human homolog when one has been identified. " H . location" indicates the map position of this homolog within the human karyotype.

Table 2. Chr 17 map. Site 0.00 0.50 0.50 0.75 1.00 1.50 d2 2.00 A 2.00 inl 2.00 2.00 2.00 2.00 2.50 3.00 3.02 3.07 dpl 3.10 3.15 d3 d4 d5 3.30 3.35 3.40 3.60 3.60 3.70 3.72 3.73 3.80 3.85 3.87 #f 4.10 6.03 t in2 6.90 7.20 7.20 7.30 7.50 7.60 g.15 Ii g.35 8.35 8.38 8.38 L38 ~.45 .50 L55 g.60 ,~8.65 8.70 T(1;17)lg0Ca 8.70

dl

Loeus DlTWasTO D I 7Au116 DITTu I D17MIT18 D17I.~h 48 D17MIT19 DITAu 9 Ted-1 Tep- 4 Tcp- 5 Tcp- 8 Tcp- 9 Tctex- 1 DITTu53A DITTu52 D17Leh1191 D17Au 31 D17Au2171 DI7Leh 66EI Tcp-lOa D17Leh 66EII D17Au21711 D17Au 311 D17Leh11911 D17Tu5 DI 7Tu53B D17Her139 D17Her190 T her Tas DI7Tu34 D17Au119 qk D17Au 10 DI7RpI7 D17LehS08 Pig lgf2 r Tme DI7Au76 Ted-4 tel-w73 Mas Tcp- l x Tcp- 1 Sod-2 D17Leh66Dgl Tcp-lOb Tcr

Type D D D D D D D V B B B B BD D D D D D D BD D D D D D D D D VBD V V D D V D BD D BD BD V D V V BD BD BD BD D BD V

From To 0.00 0.00 0.00

1.00 1.00 1.50

0.00

3.00

1.00 1,00 1.00 1.00 1.00

3.00 3.00 3.00 3.00 3.00

3.00

3.30

3.40

3.80

2.20 3.40 3.90

6.00 8.65 9.90

8.15 8.15 8.15

8.60 8.60 8.60

Reference 183 59 58 30 30 30 30

Phys Method I DT DT L DLPT A L DT T T T T T DT I Fr L I PR L T I PR I LTI I DP DT DT I DPT L I PT t P I P V DLP L D L A DL DL [ DT I DLRP P I DP [ DP I DP DP T D DLP PI DLPIR DP DPT LIP LP

H. s~nbol H. location

TCPIO

6q21-q27

PLG IGF2R

6q26-q27 6q26-q27

MAS

6q24-q27

TCP1 SOD2

6q26-q27 6q21

TCPIO

6q27


$250


Table 2. Continued. Si~ 8.75 8.78 8.80 8.81 8.85 8.90 9.00 9.01 9,02

d7

d8

I

Locus

Dl7Leh 66Dbl D17Leh 66Dg2 Tcp-lOc Hst-1 Dl7Leh 66Db2 DI 7Leh 66Dg3 Tete-2 Dt7Leh 9 t(17)- 2Pas DI 7Tu30 D17Tu33 D17Au 17 D17Au 31 D I 7Au 49 D17Au 53 D17Au144 D17Leh 80 D17Tu25 D17Tu43 Tcte.3 D17TuSO Tera-1 D I 7Leh 55 D I 7Leh l 11 Thbs -2 D17Leh550 Tcd-3 D17Leh122 3 D17Leh 94 5 Zfa8 5 74~a12 s zCats 5 Zfa29 9 DI7LeM43 10lTLeh54 2 DITTu36 2 Hkrl-ml7" 2 NTfin12 2 tcbwl8 0 D17LehlSO 0 eld 11.70 DI7AuI26 11.70 tcl- 0 11.80 Fu 12.00 D16S259h 12.00 Dl7Leh 12 12.00 Hba-ps4 12.43 Xmv-36 13.30 9" 114.35 Tcp-11 !14.70 D17TIdO 14.70 Ras/3 14.80 D17Au 7 14.80 tcl-w12 14.90 Hst-4 .5.00 Odc-rsl5 5.14 D17Au16 5.14 D17Au57 15.14 DI7AulO0 15,15 Bemv-I 15.15 Tctex- 3 15.15 Tctex- 7B 15.15 Tctex-12 15.40 DI7Ms829P2" 15.40 D17Ms836P2" 15.90 Top- 3 15.90 Tcp- 6 15.90 Tcp- 7 i6,00 Glo-t 16.40 D17Leh 26 16.40 Pim-1 16.50 Cxv-1

Type From To D D BD V 8.62 9.00 D D D D V 8.84 9.20 D 6.00 12.50 D 6,00 12.50 D 8.80 10.00 D 8.80 I0.00 D 8.80 10.00 D 8.80 10.00 D 8.80 10.00 D 9.00 i0.00 D 8.50 10.50 D 9.00 10.00 BD 9.00 10.00 D 9.O2 10.00 BD 9.04 10.00 D 9.00 10.50 D 9.00 10.50 BD 8.80 10.80 D V 8.85 11,00 D 9.20 10.70 D D D D D D D D 10.04 11.00 D 10.04 11.00 BD 10.04 11.00 V 10.04 11.00 D VB D V V D D D D 11.45 13.40 V BD 10.20 18.50 D 14.20 15.20 D 14.20 15.20 D V V 13.50 16.30 D 14.00 16.00 D 9.98 20.30 D 9.98 20.30 D 9,98 20.30 D 10.00 20.30 BD 10.00 20.30 BD 10.00 20,30 BD 10.00 2 0 3 0 D 13.40 17.40 D 13.40 17.40 B 13.40 18.40 B 13.40 18.40 B 13.40 18.40 B D VBD B

l~ys Method H. s~mabol H. location

I I I

PT PT FFI L I PT I PT v P L L SLR SLR T T T T T T L A LP I PT I LP I LP I LP I LPTR LTI LR T PT DLPR DP DPRLT DP DPR DLPR DLPR L D RDT D LR L LT L DL P DPR v DLPR L L TI L L LT L L L T T T P P I P v P L L T T T L LR LR L

TCPIO

6q21-q27

6q21-q27

THBS2

6q27

19?

D16S259

16p13.3

GLOI

6p21.2-.3

PIM

6pl 1-21.1


L . M . S i l v e r e t al.: M o u s e C h r 17

$251

Table 2. Continued. Site

Locus

16.85 Tcd-2 17.00 Pmv-57 17.20 D21S56h 7.40 Cbs in4 17,40 Crya-I 17.45 DI7Ms225P2" 17.50 Ggm-1 17.70 DI7Au 64 17.90 D17Au127 18.20 tel-w5 18.30 DITMIT16 18.34 Tctex-11 18.35 Tctex-lO 18.36 Tctex- 9 18.37 Tctex- 8 18.38 Tctex 7A 18.40 H-2Kel 18.41 H-2Ke2 18.42 Rps18 18.43 H-2K2 18.44 H-2K 18,46 Ring1" 18.47 Ring2" 18.48 H-2Ke4 18.49 H-2Ke5 18.50 Co111a2 18-51 H-2Pb 18.52 H-2Na 18.53 Ring3"' 18-54 4.24A" 18.55 4.24F" 18.56 H-2Ma 18.57 H-2Mb2 18.58 H-2Mbl 18.59 Lmp-2 18.60 Tap-I 18.61 Tap-2 18,62 Lmp-7 18.63 H-20b 18.64 H-2Ab 18.65 H.2Aa 18.66 H-2Ebl 18.67 H-2Eb2 18.70 H-2Ea 18.73 lnt-3 18.75 DI7MIT13 18.77 Cyp21 18.80 C4 18.81 Cyp21-ps 18.83 C4SIp 18.84 Rd In4 18.85 B f 18.86 C2 18,87 Bay8 18.88 Bat-9 18.90 Bat-7 18.91 D17Tu2 lg,91 D17Tu3 18.91 D17Tu4 18.93 Neu-1 18.94 Hsp70 18.95 Hsc70t 18.95 Rnu14 18.98 Csp 1 18.98 Orch-1 18.99 Bat-6 19.00 Bat-5 19.01 Bat-4 19.02 Bat-2 19.03 Bat-3 In4 19.04 D17Slk1 19.05 Tnfa

T ~ r From To V 13.50 20.20 D 14.00 20.00 D BD BD D 16.50 18.40 B 17.00 18.00 D D V 17.90 18.50 D BD BD BD BD BD BD BD BD BD BD BD BD BD BD BD BD BD BD BD BD BD BD BD B BD BD B BD BD BD BD BD BD BD 18.65 18.80 D 18.70 18.80 BD BD" D BD BD BD BD BD BD BD D 18.72 19.10 D 18.72 19,10 D 18,72 19,10 B 18.81 I9.05 BD 18.89 18,99 BD 18,89 19.00 D 18,89 19,00 BD 18.95 19.00 VBD 18,95 19.00 BD BD BD BD BD BD BD

P h ~ Method H. symbol H. location

~ ------

--

] [ -I [ [ I [ v --

----------

T LR LR LP LPIR L L LT LT L LR P P P P P P P P LP LP P P P P P P P P P P P P P L

P P L P PLR P P PLR P L LR P P P P LP P P P P L L L L L PLR L P L L P P P P P P P

D21S56 CBS CRYA1

21q22.3 21q22.3 21q22.3

KE3 HLA HLA RING1 RING2 R1NG5 KE5 COL11A1 DPB DNA RING3

61921.3

DMA DMB DMB RING12 TAP1

6p21.3 6921.3 6p21.3 6p21.3 6p21.3

6p21.3 6p21.3 6p21.3 6p21.3 6p21.3 6p21.3 6p21.3 6p21.3 6p2L3

rae2

6p21.3

RINGIO DOB DQBI DQAI DRBI DRB2 DRA

6p21.3 6921.3 6p21.3 6p21.3 0p21.3 6p21.3 6p21.3

CYP21P C4 CYP21A1

6p21.3 6p21.3 6p21.3

RO

6p21.3

BF C2 BAT8 BAT9 BAT7

6p21.3 6p21.3 6p21.3 6p21.3 6p21.3

NEU HSPAI

6p21.3 6p21.3

BAT6 BAT5 BAT4 BAT2 BAT3

6p21.3 6p21.3 6p21.3 6p21.3 6p21.3

TNFA

6p21.3


$252


Table 2. Continued.

d7

:i

,iii:'

Site IAx;tls 19.06 TM, 19.08 Bat.1 19.09 H.2D 19.09 Hh-I 19.10 H-2D2 19.It H.2D3 19.12 H.2D4 19.13 H-2L 19.14 H-2Q 1 19.15 H-2Q 2 19.16 H-2Q 4 19.17 H-2Q 5 19.18 H-2Q 6 19.19 H-2Q 7 19.20 H.2Q 8 19.21 H-2Q 9 19.22 H - 2 Q m 19.23 O0"3-rs7 19.72 H-2T24 19.73 H-2T23 19.74 H-2T22 19.75 H-2T21 19.76 H-2T20 19.77 H-2TI9 19.78 H-2T18 19.79 H-2TI7 19.80 H-2TI6 19.82 grr 19.82 H-2Tlev 19.83 tcl-12 19.85 Tse 19.86 Tctex- 4 19.86 Tctex- 5 19.86 Tctex- 6 19.89 H-2TI5 19.90 H-2TI4 19.91 H-2TI3 19.92 H-2TI2 19.95 H-2TI1 19.96 H-2TIO 19.97 H-2T 9 19.98 H-2T 8 19.99 H-2T 7 20.00 H-2T 6 20.01 H-2T5 20.02 H-2T4 20.03 H-2T 3 20.04 H-2T 2 20.05 H-2T 1 20.13 DI 7Leh171 20.16 D I 7Leh108,4 20.17 D I 7LeM 08B 20.20 DI7Tu24 20.20 D I 7Tu3 2 20.20 D l 7Ted 2 20.20 tcI-Lub l 20.27 H-2MI 20.28 H-2M7 20.30 H-2M8 20.31 H-2M6 20.32 H.2M4 20.33 H-2M5 20.40 D17Tul9 20.44 H-2M2 20.45 H-2M3 20.50 Dl7Leh 18 20.50 D I 7Leh 89 20.50 D I TLeM67 20.50 D17Leh5 25 20.50 D17TIM9 20.50 Tcd-5

T~e BD BD BD B BD BD BD BD D D BD D D BD BD BD BD BD BD BD BD D BD D BD D D BD D V D BD BD BD BD D BD BD BD BD D BD D D D D BD D D D D D D D D V D D D D D D D BD BD D D D D D V

From To

19.78 19.85 19.71 19.95 19.80 19.92 19.80 19.92 19.80 19.92

20.05 20.20

19.90 20.50

Phy, Method I P I P I P L P P P P P P P P P P P P P L L P P P P P P P P L P L L P P P P P P P P P P P P P P P P P P L L L L L L L LP P P LP P P L PLRT LT LT LRT LT LRT LRT T

H. s~,mbol H. location TNFB BAT1 HLA

6p21.3 6p21.3 6p21.3

D6S131

6p21.3-22.1


L . M . S i l v e r e t al.: M o u s e C h r 17

$253

Table 2. Continued. Site 20.80 21.05 21.55 21.80 21.80 21.80 22.50 2250 22.80 22.80 23.00 23.00 23.35 23.50 23.50 23.50 23.70 23.75 23.90 23.9(I 23.90 23.90 23.90 23.90 23.90 24.20 24.40 24.60 24.80 24.95 27.00 27.00 27.20 27.50 28.10 28.50 32,00 32,00 32.00 32.20 33.50 35.00 35,30 37.10 45.00

Locus Pgk-2 Scg D17Ms638P1" DJTLeh173 D17Tu14 Mst5-3 lfi.15 Mut D17Tu16 Tp.~-I D17Tu26 DI7Tu37 DI7MITll D17MIT7 D17MIT8 Tote-1 DtTMIT9 Xmv-57 Ck-2 D17Leh27 D17Lehl16 D17Leh154 Dt7MIT6 DI7MITIO Nfya D17Leh 23 Tpx-2 Mep-1 Ce-2 rds D17Rp11 Upg-I DI7T~40 Hsp84 DITTu27 DI7Tu20 DI7MIT4 D17MIT5 DI7Tu23 C3 Rasl2.-3 Hprt-psl thf 11"-5 D17M1T3

T~lpe From BD BD 20.30 D 20.30 D 21.40 D 21.40 D 21.40 BD 20.00 BD 22.00 D BD D D 21.80 D 22.80 D D BD D D 20.50 BD 23,60 D 23.60 D 23.60 D 23.60 D D BD 23.60 D BD B B VBD 22.50 BD BD D BD D 24.20 D 28.00 D 24.00 D 24.00 D 28.00 BD D D v B D 40.00

To 21.80 22.80 22.20 22.20 22.20 25.00 23.00

24.20 23.90

27.00 24.20 24.20 24.20 24.20

24.20

27.40

32.00 29.00 40.00 40,00 36.00

50.00

Ph~s Method L L L LR L LR L LI LR LR L L LR LR LR LIR L LR L L LR LR LR LR LI LR L L L L L LR L L L L L L L LI L L L L LR

H. symbol H. location PGK2 6pl 1-21.1

MUT

6p12-21.1

TPX1

6p11-21.1

TCTE1

6pl 1-21.1

6p21.1

RDS

6p12

PGC

6p

C3

19p

Regions associated with deletions, duplications, and inversions on variant forms of the chromosome are indicated to the left of the " S i t e " column. Deleted regions are indicated with a solid line, duplicated regions are indicated with a stippled line, and t haplotype inverted regions are indicated with boxes. " d l ' " through t b l 2, " d 8 " designate the following variant chromosomes: d l - T 2 2 h , d2-T ~ d3-t"I b 2 , d4-Thp , d5-T~ l d6-qk v'a d7-t wle, and d8-t h2~ " d p l " designates a duplicated chromosomal region associated with M. rnusculus but not M. spretus chromosomes. " i n l " through "in4'" indicate the four inversions associated with t haplotypes [in(l 7)1-in(17)4, respectively]. The in(l 7)2 inversion also distinguishes M. spretus from M. musculus; the M. musculus order is shown. The " S i t e " column indicates the best current estimate of the relative position of a locus on the genetic map. In regions where physical maps are available, kb are converted into cM units assuming a ratio of 2000 kb to 1 cM. Although the site numbers are presented to two-decimal-place resolution, this is simply to indicate a relative gene order when known, and not to imply that genetic mapping has been performed to this resolution. When the gene order of closely mapped loci is ambiguous, a " F r o m - T o " range is give for the position with the site calculated as the center of this range. Regions that have been physically mapped are indicated with a vertical " ~ " in the " P h y s " column; loci that map within these regions but have not been placed on the physical map are indicated with a " ' - - . " The " M e t h o d , " " H . s y m b o l , " and " H . location" columns are the same as described in the legend to Table 1.

L.M. Silver et al.: M o u s e Chr 17

$254 Table 3. Anchor loci: traditional and simple sequence repeats. Anchors 1.50

T qk

3.87 4.00 7.20

Left primer DI7MITI9 5' GAGCTI'GGTAAATGCTI'TGC~

RJl~ht primer 5' TTGAGTACCCCGTACTTGCC

mM de] Reference 1.5 55 37

D17MIT18

5' GCAGCTCATTCTTAGTCCCTAAT

5' TCATGAGTCCCCAAACTAGC

1.5 55 37

5 ~ AAGC'Iq'GGGAAAACACTGCT

5' TI'GGCAGCACCTCTAACCT

1.5

53 45

5' 5' 5' 5' 5' 5' 5' 5'

5' 5' 5' 5' 5' 5' 5' 5'

GCCAGTGTGGTCTATAAATC CTACACTGAGCTAGGAAGA AT'fGAGGCAGGTTGAGTGAT GAAGTATGTTAAGGAAAAGC CCrCI~GGTrGCTTAGAAG GAGTCTAGACACCTAGCAAT CTACTGTTCTGAGGTCCAG CGGGAAAGCATGGAATTI'AA

1.0 1.5 1.4 1.0 1.0 1.5 1.0 1.5

53 52 53 52 51 55 55 55

45 45 45 45 45 45 45 37

5' ATGAACTCACCTACCCATGT 5 ~ CCAGAAGACAGCATTCCACA 5' TAACACCAGACATTGACCTC 5' GGTAAGCATTAGATAGAGAG 5' GATCCAGACCACACCCCCTCACCA Hsp70 5' GTAATFGCGTTGACTGTTAAAT Tnifa 5' GTTTCAGTTCTCAGGGTCCTA Tnfb 5' TTCCTGTGGCG GCCTI'ATCAG H-2Q 4 5' CCTGGAGGAATATCAATAGTG H-2M2 5' ACCTCTCACCTCTCTCTGTG D17MIT11 5' TGAATrTATGAGGGGGGTCA D17MIT 7 5' TCTAATCCCATGTATATGTGGTTGG D17MIT8 5' TCTAATCCCATGTATATGTGGTGG D17MIT9 5' TCAGCCCTrAAAAATTACTCTTGG DI7MIT6 5' GTACATGTAGAGAAATGGAGGTG D17MIT10 5' TGCACTTGCATAAGGAAAAC

5' 5' 5' 5' 5' 5' 5' 5' 5' 5' 5' 5' 5' 5' 5' 5'

GCAGACAGGAAGTTFAGTAC GTATGTCACW_JC~TAGTFGACAGG AGTCTAGATATGTGTCTCCC TFATGATCTCCACACACGTG TCC'ITTGAGAGCCAAGCTTGAAGG AGTGCTGCTCCCAACATTACT CAGGATTCTGTGC~AATCTGG AGACAATGGGTAACAGAGGCA ATACAGAGAAACCCTATCTCAA TGGAGAGACGTCCTATGATG TGTCCCATATCTCTCTTTATACACA TFCCTCTGGACTCCTTGGG TTCCTCTGGACTCCTTGGG CCCCACCAACTGTCCTCTAA GCTTATGTTCTTTAACAAGAATGT( GACTTTGGGGCCTACTTATG

1.0 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5

53 55 55 55 55 55 60 55 55 55 55 55 55 55 55 55

45 37 37 37 37 l12a l12a 112a l12a 37 37 37 37 37 37 37

D17MIT4 DI7MIT5 C3 D17MIT3 D17MIT 1 D17MIT2

5' 5' 5' 5' 5' 5'

TTTCTGAAAAAGCCTCTCAA CCCTFTCCTCCAAACTCTCA TCATAAGTAGGCACACCAATGC GCAAAGTCATGTACTCTGAG TGCAAAAATGTATGTGCCTG TFGAGTTTAAGCCCCTAGAATCC

1.5 55 37 1.5 55 37 55 37 1.5 55 37 1.5 55 37 1.5 55 37

11.70 D17Au126

tf

13.30 14.80 14.80 15.14 15.14 15.14 15.14 15.14 Pim-1 16.40 Crya-1 17.40 17.90 18.30 18.64 H-2 18.67 18.75 18.94 19.05 19.06 19.16 20.44 23.35 23.50 23.50 23.70 23.90 23.90 Ce-2 24.80 32.00 32.00 C3 32.20 (on 177) 45.00 (on 17?) 50.00 (on 17?) 50.00

Dt7Au 7 D17Au 7 D17Au16 D17Au 57 D17Au 57 D17Au100 D17Au100 Pim-1

TACTATGTGACTGAGGTCAG ATGCTATAAGCW_rGCA'FI'CG TATGGTGCACTCTCAGTACT TACTGCCATTAGTGATCCAT TTGATI'TCTGCACATATGCC GATGGC~ATTGGTGTTGAAC GCCTGGTCTGAAGTAAGTC TCGAGC~GGTTGAACGAAC

DI7AuI27 DI7MIT16 H-2Ab H-2Eb2 D17MIT13

5' GCTGTGCTI'CCACACTCAGT 5' TGGGAACTTI'CCAGACTTCC 5 ~ AGAACAGGACACCGGACATC 5' GATCTI'TrCTTATI'CTGGTT 5' TGCTTGAAATCCTGGGTTCA 5' ACAAACATGTTGGCCTAATTCC

Traditional anchor loci are indicated in the left column, Positions along the chromosome (in cM distances from the centromere) are indicated in the second column, and loci for which SSR assays have been developed are indicated in the third column. Columns 4 and 5 contain the primer sequences used for PCR amplification of the SSR loci. Column 6 indicates the molarity of Mg 2§ used in the PCR reaction; column 7 indicates the annealing temperature, and the last column contains the reference.

The final component of this report is the cytogenetic map presented in Fig. 1. Fifteen cloned loci have been mapped to the chromosome directly by in situ hybridization, with the results shown in this figure. In general, cytogenetic map distances correspond well to those obtained by linkage analysis with no major discrepancies. When these two maps are considered in conjunction with available physical mapping information, the total length of Chr 17 can be estimated at not more than 50 cM (in linkage units), which is equivalent to approximately 100 Mb. This linkage distance is considerably less than that estimated in older studies based on a comparative analysis of the lengths of all mouse chromosomes. A detailed discussion of the various means by which particular loci have been mapped was presented

in the first report from this Committee. The first report also included information on partial t haplotypes not repeated here. The most current version of the complete database for Chr 17 will be made available to all interested scientists as a Macintosh Excel or Lotus 1-2-3 (DOS) file. To receive a copy, please send a blank, pre-formatted, 3.5-inch disk with a self-addressed, stamped envelope to the chairman of the Committee. Be sure to indicate whether the disk is for the Macintosh or an IBMcompatible computer, and the version number of the spreadsheet program that you run. This Chr 17 database has also been incorporated as a component in the Encyclopedia of the Mouse Genome, which runs on a Sun workstation; interested investigators should contact Tom Snell at The Jackson Laboratory.


rcp.lx

cp-l l

$255 11. Bennett, D. and Dunn, L.C.: A lethal mutant (tw18)in the house mouse showing partial duplications. J Exp Zool 143: 203-219, 1960. 12. Bibbins, K.B., Tsai, J.-Y., Schimenti, J., Sarvetnick, N., Zoghbi, H.Y., Goodfetlow, P., and Silver, L.M.: Human homologs of two testes-expressed loci on mouse Chromosome 17 map to opposite arms of chromosome 6. Genomics 5: 139-143, 1989. 13. Blanche, H., Wright, L.G., Vergnaud, G., de Gouyon, B., Lauthier, V., Silver, L.M., Dausset, J., Cann, H.M., and Spielman, R.: Genetic mapping of three human homologues of murine t-complex genes localizes TCPIO to 6q27, 15 cM distal to TCP1 and PLG. Genomics 12: 826-828, 1992. 14. Blomer, K., Bennett, K., Yu, L., and Fischer-Lindahl, K.: Molecular analysis of the E to D interval in the H-2 complex. Seventh International Workshop on the Molecular Genetics o f the Mouse Svaty Petr: April 22-27, 1990.

I Bk~-2

Fig. 1. Cytogenetic map of Chr 17 showing G-banding pattern and in situ hybridization results.

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76.

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Note added in proof. D17M1T18 is shown incorrectly in Table 2 at

position 0.75. The correct position is 4.0 (Lai and Artzt 1992).

Mapping of six DNA markers on mouse chromosome 17.

Gene expression in salivary glands: effects of diet and mouse chromosome 17 locus regulating macronutrient intake.

Linkage disequilibrium between H-2 and t complexes in chromosome 17 of the mouse.

Delineation of the t complex on mouse chromosome 17 by in situ hybridization.

The proximal end of mouse chromosome 17: new molecular markers identify a deletion associated with quakingviable.

The isolation of evolutionarily conserved Eag I end-clones from mouse chromosome 17 using cloned DNA.

Mapping of the L-methylmalonyl-CoA mutase gene to mouse chromosome 17.

Assignment of the homolog of the MAS1 oncogene to mouse chromosome 17.

A novel mouse chromosome 17 hybrid sterility locus: implications for the origin of t haplotypes.

A genetic linkage map of chromosome 17.

Flecked retina associated with ring 17 chromosome.

Chromosome 17- and p53 changes in lymphoma.

Ring 17 chromosome detected by amniocentesis.

Miller-Dieker syndrome with ring chromosome 17.

Genetic map of nine polymorphic loci comprising a single linkage group on rat chromosome 10: evidence for linkage conservation with human chromosome 17 and mouse chromosome 11.

Mouse chromosome 15.

Mouse chromosome 16.

Mouse chromosome 19.

Mouse chromosome 9.

Mouse chromosome 7.

Mouse Y chromosome.

Mouse chromosome 18.

Mouse chromosome 10.

Mouse chromosome 13.