CLINICAL RESEARCH e-ISSN 1643-3750 © Med Sci Monit, 2016; 22: 2253-2266 DOI: 10.12659/MSM.896527
Associations Between TGFA/TGFB3/MSX1 Gene Polymorphisms and Congenital Non-Syndromic Hearing Impairment in a Chinese Population
Received: 2015.11.03 Accepted: 2015.12.17 Published: 2016.06.29
Authors’ ABCDEF Contribution: Jihong Du Study Design A CDEF Jianhua Deng Data Collection B Statistical Analysis C Data Interpretation D Manuscript Preparation E Literature Search F Funds Collection G
Corresponding Author: Source of support:
Background:
Material/Methods:
Results:
Conclusions:
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Department of Otorhinolaryngology, The First People’s Hospital of Kunshan, Kunshan, Jiangsu, P.R. China
Jianhua Deng, e-mail: [email protected] Departmental sources
The aim of this study was to investigate whether the TGFA/TGFB3/MSX1 gene polymorphisms and haplotypes lead to individual differences between congenital non-syndromic hearing impairment (NSHI) patients and normal people in a Chinese population and to analyze the risk factors for NSHI. Between December 2010 and September 2014, 343 congenital NSHI patients were recruited as cases, and 272 healthy subjects were recruited as controls. Denaturing high-performance liquid chromatography (DHPLC) was used to identify genotypes, SHEsis software was used to conduct gene linkage disequilibrium and haplotype analyses, and regression analysis was performed to identify risk factors for congenital NSHI. The distribution of genotype frequencies and allele frequencies of TGFA rs3771494, TGFB3 rs3917201 and rs2268626, and MSX1 rs3821949 and rs62636562 were significantly different between the case and the control groups (all P
Associations Between TGFA/TGFB3/MSX1 Gene Polymorphisms and Congenital Non-Syndromic Hearing Impairment in a Chinese Population
Received: 2015.11.03 Accepted: 2015.12.17 Published: 2016.06.29
Authors’ ABCDEF Contribution: Jihong Du Study Design A CDEF Jianhua Deng Data Collection B Statistical Analysis C Data Interpretation D Manuscript Preparation E Literature Search F Funds Collection G
Corresponding Author: Source of support:
Background:
Material/Methods:
Results:
Conclusions:
MeSH Keywords:
Full-text PDF:
Department of Otorhinolaryngology, The First People’s Hospital of Kunshan, Kunshan, Jiangsu, P.R. China
Jianhua Deng, e-mail: [email protected] Departmental sources
The aim of this study was to investigate whether the TGFA/TGFB3/MSX1 gene polymorphisms and haplotypes lead to individual differences between congenital non-syndromic hearing impairment (NSHI) patients and normal people in a Chinese population and to analyze the risk factors for NSHI. Between December 2010 and September 2014, 343 congenital NSHI patients were recruited as cases, and 272 healthy subjects were recruited as controls. Denaturing high-performance liquid chromatography (DHPLC) was used to identify genotypes, SHEsis software was used to conduct gene linkage disequilibrium and haplotype analyses, and regression analysis was performed to identify risk factors for congenital NSHI. The distribution of genotype frequencies and allele frequencies of TGFA rs3771494, TGFB3 rs3917201 and rs2268626, and MSX1 rs3821949 and rs62636562 were significantly different between the case and the control groups (all P
