The Breast xxx (2015) e1ee4

Contents lists available at ScienceDirect

The Breast journal homepage: www.elsevier.com/brst

Conservative surgery for multifocal/multicentric breast cancer Matthijs V. Nijenhuis, Emiel J.Th. Rutgers* Department of Surgery, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands

a r t i c l e i n f o

a b s t r a c t

Article history: Available online xxx

Multifocal (MF) and multicentric (MC) breast cancer is regularly considered a relative contraindication for breast-conserving therapy (BCT). There are two reasons for this wide spread notion:

Keywords: Breast cancer Breast-conserving surgery Multifocal Multicentric MRI Prognosis

1. Perceived higher risk for in-breast recurrence since it is assumed that in MF/MC cancer the risk of more invasive foci in the breast is greater, and therefore radiotherapy possibly less effective. 2. Less good cosmetic outcome due to wider excisions, either segmental resection or quadrantectomy in multifocal, or multiple wide local excisions in multicentric disease. However, we concur that if optimal ‘cytoreductive surgery’ is achieved this will result in good local control (i.e. in-breast relapse