CORRESPONDENCE

MULTICYSTIC RENAL DYSPLASIA IN TWO CONSECUTIVE MALE INFANTS To the Editor: We read with interest a recent article by Murugasu et all on familial renal adysplasia. The authors described two families in each of which two siblings were affected by multicystic renal dysplasia, a condition usually sporadic and noninherited in occurrence. We would like to describe a family in which a male infant had bilateral multicystic kidneys and a subsequent male infant had a unilateral multicystic kidney. A woman suffered from oligohydramnios during her third pregnancy. Fetal ultrasonography showed bilateral multicystic kidneys. A male infant, delivered by induction at 28 weeks of pregnancy, had a Potter facies and died. Autopsy showed bilateral multicystic kidneys and absent ureters. In her fourth pregnancy, fetal ultrasonography at 28 weeks showed a left unilateral multicystic kidney. A male infant delivered at 39 weeks of pregnancy had on ultrasound a left unilateral multicystic kidney without the usual reniform configuration. Renal scintigraphy and renography showed nonfunction of the left kidney. No reflux was found by cystography. Ultrasonography at age 7 months showed compensatory hypertrophy of the right kidney. Ultrasound screening of the parents and two

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elder sisters showed no renal abnormalities. The occurence of multicystic renal dysplasia in two brothers born to apparently unaffected parents would indicate autosomal or X-linked recessive inheritance. Hereditary renal adysplasia, a term coined by Buchta et aV usually refers to the occurrence of unilateral or bilateral renal agenesis in two or more family members. However, adysplasia, according to Buchta and his colleagues,2 in principle includes cystic renal dysplasia. Toshio Murakami, MD Hatsumi Kawakami, MD Junko Kimoto, MD Masakatsu Sase, MD Yamaguchi University School of Medicine Yamaguchi, Japan

REFERENCES 1. Murugasu B, Cole BR, Hawkins EP, et al: Familial renal adysplasia. Am J Kidney Dis 18:490-494, 1991 2. Buchta RM, Viseskul C, Gilbert EF, et al: Familial bilateral renal agenesis and hereditary renal adysplasia. Z Kinderheilk 115:111-129,1973

American Journal of Kidney Diseases, Vol XX, No 6 (December), 1992: p 676

Multicystic renal dysplasia in two consecutive male infants.

CORRESPONDENCE MULTICYSTIC RENAL DYSPLASIA IN TWO CONSECUTIVE MALE INFANTS To the Editor: We read with interest a recent article by Murugasu et all o...
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