The New England Journal of Medicine Downloaded from nejm.org at UC SHARED JOURNAL COLLECTION on March 10, 2015. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at UC SHARED JOURNAL COLLECTION on March 10, 2015. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at UC SHARED JOURNAL COLLECTION on March 10, 2015. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at UC SHARED JOURNAL COLLECTION on March 10, 2015. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at UC SHARED JOURNAL COLLECTION on March 10, 2015. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at UC SHARED JOURNAL COLLECTION on March 10, 2015. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved.

Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis.

The presence of the hepatitis B e antigen (HBeAg) in serum is known to be a marker of a high degree of viral infectivity. However, fulminant hepatitis...
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