Cancer Letters 360 (2015) 205–212
Contents lists available at ScienceDirect
Cancer Letters j o u r n a l h o m e p a g e : w w w. e l s e v i e r. c o m / l o c a t e / c a n l e t
Original Articles
Nanoparticle delivery of an SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma Radhika Iyer a,1, Jamie L. Croucher a,1, Michael Chorny b,c,1, Jennifer L. Mangino a, Ivan S. Alferiev b,c, Robert J. Levy b,c, Venkatadri Kolla a, Garrett M. Brodeur a,c,* a
Division of Oncology, The Children’s Hospital of Philadelphia, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA Division of Cardiology, The Children’s Hospital of Philadelphia, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA c Department of Pediatrics, Perelman School of Medicine, Philadelphia, PA 19104, USA b
A R T I C L E
I N F O
Article history: Received 10 December 2014 Received in revised form 3 February 2015 Accepted 7 February 2015 Keywords: Irinotecan Nanoparticles Neuroblastoma SN38 Tocopherol succinate
A B S T R A C T
Neuroblastoma (NB) is the most common and deadly solid tumor in children. The majority of NB patients have advanced stage disease with poor prognosis, so more effective, less toxic therapy is needed. We developed a novel nanocarrier-based strategy for tumor-targeted delivery of a prodrug of SN38, the active metabolite of irinotecan. We formulated ultrasmall-sized (
Contents lists available at ScienceDirect
Cancer Letters j o u r n a l h o m e p a g e : w w w. e l s e v i e r. c o m / l o c a t e / c a n l e t
Original Articles
Nanoparticle delivery of an SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma Radhika Iyer a,1, Jamie L. Croucher a,1, Michael Chorny b,c,1, Jennifer L. Mangino a, Ivan S. Alferiev b,c, Robert J. Levy b,c, Venkatadri Kolla a, Garrett M. Brodeur a,c,* a
Division of Oncology, The Children’s Hospital of Philadelphia, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA Division of Cardiology, The Children’s Hospital of Philadelphia, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA c Department of Pediatrics, Perelman School of Medicine, Philadelphia, PA 19104, USA b
A R T I C L E
I N F O
Article history: Received 10 December 2014 Received in revised form 3 February 2015 Accepted 7 February 2015 Keywords: Irinotecan Nanoparticles Neuroblastoma SN38 Tocopherol succinate
A B S T R A C T
Neuroblastoma (NB) is the most common and deadly solid tumor in children. The majority of NB patients have advanced stage disease with poor prognosis, so more effective, less toxic therapy is needed. We developed a novel nanocarrier-based strategy for tumor-targeted delivery of a prodrug of SN38, the active metabolite of irinotecan. We formulated ultrasmall-sized (
