Eur J Pediatr DOI 10.1007/s00431-014-2347-x
SHORT COMMUNICATION
Neonatal Kawasaki disease: case report and data from nationwide survey in Japan Mayumi Hangai & Yasuo Kubota & Jiro Kagawa & Mayumi Yashiro & Ritei Uehara & Yosikazu Nakamura & Masato Takeuchi
Received: 22 January 2014 / Revised: 21 May 2014 / Accepted: 23 May 2014 # Springer-Verlag Berlin Heidelberg 2014
Abstract Kawasaki disease (KD) is a systemic vasculitis that develops during childhood, with a peak incidence from 6 to 23 months of age. KD also affects younger children, including neonates. We herein describe the case of a 22-day-old patient with incomplete KD. Some characteristics of neonatal KD are also presented with a review of nationwide surveys of KD in Japan involving approximately 130,000 patients during a 12year period. The surveys identified 23 neonatal cases, accounting for 1/5,500 of patients of all ages with KD. We found that the characteristics of neonatal KD are likely to be incompatible with the classic criteria for KD and that the incidence of coronary disorders in neonatal patients was not statistically higher than that in older patients. These findings are very Communicated by David Nadal M. Hangai (*) : Y. Kubota : J. Kagawa Department of Pediatrics, Fujieda Municipal General Hospital, 4-1-11 Surugadai, Fujieda, Shizuoka, Japan e-mail: [email protected]
similar to those of previous reports of neonatal KD. Conclusion: Neonatal KD is rare and often presents with only a few features of KD. In addition, both neonatal and older patients with KD are at risk of coronary disorders. These characteristics present a challenge to pediatricians in the diagnosis and treatment of febrile neonates. Keywords Coronary disorders . Epidemiology . Mucocutaneous lymph node syndrome . Neonate Abbreviations CI IVIG KD OR
Confidence interval Intravenous immunoglobulin Kawasaki disease Odds ratio
Y. Kubota e-mail: [email protected]
Introduction
J. Kagawa e-mail: [email protected]
Kawasaki disease (KD) is an acute febrile disease and one of the most common forms of vasculitis in childhood, particularly in East Asia. It typically affects infants and toddlers from 6 months to 2 years of age, but younger infants can also be affected. One retrospective survey revealed that
SHORT COMMUNICATION
Neonatal Kawasaki disease: case report and data from nationwide survey in Japan Mayumi Hangai & Yasuo Kubota & Jiro Kagawa & Mayumi Yashiro & Ritei Uehara & Yosikazu Nakamura & Masato Takeuchi
Received: 22 January 2014 / Revised: 21 May 2014 / Accepted: 23 May 2014 # Springer-Verlag Berlin Heidelberg 2014
Abstract Kawasaki disease (KD) is a systemic vasculitis that develops during childhood, with a peak incidence from 6 to 23 months of age. KD also affects younger children, including neonates. We herein describe the case of a 22-day-old patient with incomplete KD. Some characteristics of neonatal KD are also presented with a review of nationwide surveys of KD in Japan involving approximately 130,000 patients during a 12year period. The surveys identified 23 neonatal cases, accounting for 1/5,500 of patients of all ages with KD. We found that the characteristics of neonatal KD are likely to be incompatible with the classic criteria for KD and that the incidence of coronary disorders in neonatal patients was not statistically higher than that in older patients. These findings are very Communicated by David Nadal M. Hangai (*) : Y. Kubota : J. Kagawa Department of Pediatrics, Fujieda Municipal General Hospital, 4-1-11 Surugadai, Fujieda, Shizuoka, Japan e-mail: [email protected]
similar to those of previous reports of neonatal KD. Conclusion: Neonatal KD is rare and often presents with only a few features of KD. In addition, both neonatal and older patients with KD are at risk of coronary disorders. These characteristics present a challenge to pediatricians in the diagnosis and treatment of febrile neonates. Keywords Coronary disorders . Epidemiology . Mucocutaneous lymph node syndrome . Neonate Abbreviations CI IVIG KD OR
Confidence interval Intravenous immunoglobulin Kawasaki disease Odds ratio
Y. Kubota e-mail: [email protected]
Introduction
J. Kagawa e-mail: [email protected]
Kawasaki disease (KD) is an acute febrile disease and one of the most common forms of vasculitis in childhood, particularly in East Asia. It typically affects infants and toddlers from 6 months to 2 years of age, but younger infants can also be affected. One retrospective survey revealed that
