Nephrotic syndrome associated with acquired immunodeficiency syndrome in children Elizabeth Ingulli, MD,* Amir Tejani, MD, Senih Fikrig, MD, A n t h o n y Nicastri, MD, C. K. Chen, MD, a n d A n d r e w Pomrantz, MD From the Renaland Immunology Divisionsof the Children'sMedical Center of Brooklynand the Department of Pathology, State Universityof New York Health Science Center at Brooklyn We report here the cases of 45 children in whom nephrotic syndrome developed, from among 164 children (55% male, 90% black) followed in our acquired immunodeficiency syndrome clinic from 4984 through 1990. Mean age at onset of nephrotic syndrome was 4.9 _+ 2.6 years. Fourteen patients were b|ack and one was Hispanic. Seventy-three percent of our patients with nephrotic syndrome were girls. The mean duration of clinical acquired immunodeficiency syndrome before development of nephrotic syndrome was 1.7 _+ 4.1 years, in eight patients, nephrotic syndrome appeared between 3 and i i months after in, travenous infusions of immune globulin or albumin were administered as part of a research protocol; this incidence (8/47) was higher than the incidence of nephrotic syndrome among those who did not receive intravenous infusions (7/ 117, p