Research Article
Neuropharmacological evaluation of a novel 5‑HT3 receptor antagonist (6g) on chronic unpredictable mild stress‑induced changes in behavioural and brain oxidative stress parameters in mice Shvetank Bhatt, Mahesh Radhakrishnan, Ankur Jindal, Thangaraj Devadoss, Arghya Kusum Dhar
ABSTRACT Aim: The aim of the study was to evaluate a novel 5 HT 3 receptor antagonist (6g) on chronic stress induced changes in behavioural and brain oxidative stress parameter in mice. A complicated relationship exists among stressful stimuli, body’s reaction to stress and the onset of clinical depression. Chronic unpredictable stressors can produce a situation similar to human depression, and such animal models can be used for the preclinical evaluation of antidepressants. Materials and Methods: In the present study, a novel and potential 5‑HT 3 receptor antagonist (4‑benzylpiperazin‑1‑yl)(3‑methoxyquinoxalin‑2‑yl) methanone (6g) with good Log P (3.08) value and pA2 (7.5) values, synthesized in our laboratory was investigated to study the effects on chronic unpredictable mild stress (CUMS)‑induced behavioural and biochemical alterations in mice. Mice were subjected to different stress paradigms daily for a period of 28 days to induce depressive‑like behaviour. Results: The results showed that CUMS caused depression‑like behaviour in mice, as indicated by the significant (P
Neuropharmacological evaluation of a novel 5‑HT3 receptor antagonist (6g) on chronic unpredictable mild stress‑induced changes in behavioural and brain oxidative stress parameters in mice Shvetank Bhatt, Mahesh Radhakrishnan, Ankur Jindal, Thangaraj Devadoss, Arghya Kusum Dhar
ABSTRACT Aim: The aim of the study was to evaluate a novel 5 HT 3 receptor antagonist (6g) on chronic stress induced changes in behavioural and brain oxidative stress parameter in mice. A complicated relationship exists among stressful stimuli, body’s reaction to stress and the onset of clinical depression. Chronic unpredictable stressors can produce a situation similar to human depression, and such animal models can be used for the preclinical evaluation of antidepressants. Materials and Methods: In the present study, a novel and potential 5‑HT 3 receptor antagonist (4‑benzylpiperazin‑1‑yl)(3‑methoxyquinoxalin‑2‑yl) methanone (6g) with good Log P (3.08) value and pA2 (7.5) values, synthesized in our laboratory was investigated to study the effects on chronic unpredictable mild stress (CUMS)‑induced behavioural and biochemical alterations in mice. Mice were subjected to different stress paradigms daily for a period of 28 days to induce depressive‑like behaviour. Results: The results showed that CUMS caused depression‑like behaviour in mice, as indicated by the significant (P
