GeroScience (2017) 39:19–32 DOI 10.1007/s11357-017-9958-x
REVIEW ARTICLE
Neuroprotective mechanisms of astaxanthin: a potential therapeutic role in preserving cognitive function in age and neurodegeneration Bethany Grimmig & Seol-Hee Kim & Kevin Nash & Paula C. Bickford & R. Douglas Shytle
Received: 27 December 2016 / Accepted: 4 January 2017 / Published online: 13 February 2017 # American Aging Association (outside the USA) 2017
Abstract Astaxanthin (AXT) is a carotenoid with multiple health benefits. It is currently marketed as a health supplement and is well known for its antioxidant capacity. Recent evidence has emerged to suggest a broad range of biological activities. The interest in this compound has increased dramatically over the last few years and many studies are now applying this molecule across many disease models. Results from the current research are beginning to come together to suggest neuroprotective properties including anti-inflammatory, anti-apoptotic, and antioxidant effects, as well as the potential to promote or maintain neural plasticity. These emergent mechanisms of actions implicate AXT as a promising therapeutic agent for neurodegenerative disease. This review will examine and extrapolate from the recent literature to build support for the use of AXT in
Bethany Grimmig and Seol-Hee Kim contributed equally to this work B. Grimmig : S.
REVIEW ARTICLE
Neuroprotective mechanisms of astaxanthin: a potential therapeutic role in preserving cognitive function in age and neurodegeneration Bethany Grimmig & Seol-Hee Kim & Kevin Nash & Paula C. Bickford & R. Douglas Shytle
Received: 27 December 2016 / Accepted: 4 January 2017 / Published online: 13 February 2017 # American Aging Association (outside the USA) 2017
Abstract Astaxanthin (AXT) is a carotenoid with multiple health benefits. It is currently marketed as a health supplement and is well known for its antioxidant capacity. Recent evidence has emerged to suggest a broad range of biological activities. The interest in this compound has increased dramatically over the last few years and many studies are now applying this molecule across many disease models. Results from the current research are beginning to come together to suggest neuroprotective properties including anti-inflammatory, anti-apoptotic, and antioxidant effects, as well as the potential to promote or maintain neural plasticity. These emergent mechanisms of actions implicate AXT as a promising therapeutic agent for neurodegenerative disease. This review will examine and extrapolate from the recent literature to build support for the use of AXT in
Bethany Grimmig and Seol-Hee Kim contributed equally to this work B. Grimmig : S.
