Opinion Viewpoint
3. Doroudchi MM, Greenberg KP, Liu J, et al. Virally delivered channelrhodopsin-2 safely and effectively restores visual function in multiple mouse models of blindness. Mol Ther. 2011;19(7):1220-1229. 4. Bi A, Cui J, Ma YP, et al. Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration. Neuron. 2006;50(1):23-33.
5. Caporale N, Kolstad KD, Lee T, et al. LiGluR restores visual responses in rodent models of inherited blindness. Mol Ther. 2011;19(7):1212-1219. 6. Lin B, Koizumi A, Tanaka N, Panda S, Masland RH. Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin. Proc Natl Acad Sci U S A. 2008;105(41):16009-16014.
7. Francis PJ, Mansfield B, Rose S. Proceedings of the First International Optogenetic Therapies for Vision Symposium. Transl Vis Sci Technol. 2013;2(7):4.
OPHTHALMIC IMAGES
Nevus in a Pterygium Amir A. Azari, MD; Mozhgan Rezaei Kanavi, MD; Pimkwan Jaru-ampornpan, MD; Sherif S. Khedr, MD; Heather D. Potter, MD; Daniel M. Albert, MD; Neal P. Barney, MD A
B
C
800 µm
90 µm
A 23-year-old man presented with a 2-year history of a slow growing lesion in the left eye. The lesion consisted of a vascularized, balloon-like mass straddling the limbus nasally (A). Histopathologic examination demonstrates (B) a conjunctival epithelium with solar elastosis, consistent with a pterygium (left side), and proliferation of melanocytic cells in the stroma and epithelial-stromal interface, consistent with a compound nevus (right side). It is important to note that, except for a small area on the left (black arrowhead) that demonstrates a normal thickness, the remainder of the conjunctiva shows considerable thickening, which measures as high as 6 times the normal value in some areas. This thickening, which gives the lesion its striking clinical appearance, is due to severe reactive fibrosis and solar elastotic changes. Magnification reveals the nevus component in more detail (C [white arrowheads]).
1044
JAMA Ophthalmology September 2014 Volume 132, Number 9
Copyright 2014 American Medical Association. All rights reserved.
Downloaded From: http://archopht.jamanetwork.com/ by a University of Georgia User on 05/27/2015
jamaophthalmology.com
3. Doroudchi MM, Greenberg KP, Liu J, et al. Virally delivered channelrhodopsin-2 safely and effectively restores visual function in multiple mouse models of blindness. Mol Ther. 2011;19(7):1220-1229. 4. Bi A, Cui J, Ma YP, et al. Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration. Neuron. 2006;50(1):23-33.
5. Caporale N, Kolstad KD, Lee T, et al. LiGluR restores visual responses in rodent models of inherited blindness. Mol Ther. 2011;19(7):1212-1219. 6. Lin B, Koizumi A, Tanaka N, Panda S, Masland RH. Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin. Proc Natl Acad Sci U S A. 2008;105(41):16009-16014.
7. Francis PJ, Mansfield B, Rose S. Proceedings of the First International Optogenetic Therapies for Vision Symposium. Transl Vis Sci Technol. 2013;2(7):4.
OPHTHALMIC IMAGES
Nevus in a Pterygium Amir A. Azari, MD; Mozhgan Rezaei Kanavi, MD; Pimkwan Jaru-ampornpan, MD; Sherif S. Khedr, MD; Heather D. Potter, MD; Daniel M. Albert, MD; Neal P. Barney, MD A
B
C
800 µm
90 µm
A 23-year-old man presented with a 2-year history of a slow growing lesion in the left eye. The lesion consisted of a vascularized, balloon-like mass straddling the limbus nasally (A). Histopathologic examination demonstrates (B) a conjunctival epithelium with solar elastosis, consistent with a pterygium (left side), and proliferation of melanocytic cells in the stroma and epithelial-stromal interface, consistent with a compound nevus (right side). It is important to note that, except for a small area on the left (black arrowhead) that demonstrates a normal thickness, the remainder of the conjunctiva shows considerable thickening, which measures as high as 6 times the normal value in some areas. This thickening, which gives the lesion its striking clinical appearance, is due to severe reactive fibrosis and solar elastotic changes. Magnification reveals the nevus component in more detail (C [white arrowheads]).
1044
JAMA Ophthalmology September 2014 Volume 132, Number 9
Copyright 2014 American Medical Association. All rights reserved.
Downloaded From: http://archopht.jamanetwork.com/ by a University of Georgia User on 05/27/2015
jamaophthalmology.com
