Acta Med Scand 202: 173-177, 1977
Nocturnal H ypertriglyceridemia and H yperinsulinemia Following Moderate Evening Intake of Alcohol Marja-Riitta Taskinen and Esko A. Nikkila From Third Department of Medicine, University Hospital, Helsinki, Finland
ABSTRACT. The study was made to determine is known about the factors which determine the whether a moderate intake of alcohol in the evening individual serum triglyceride response to alcohol. influences the serum triglyceride and plasma insulin In most studies alcohol has been administered to levels during the night and in the following morning. experimental subjects after an overnight fast (2, 11. Ethanol (1.5 g/kg) was given orally between 5 and 9 13, 18,22) or as repeated small doses over a day ( 6 , p.m. to 34 subjects. The serum triglyceride and 17) and there is little if any information on the mode plasma insulin levels were followed during the night and the values compared with those taken after a of response to the most usual pattern of social sober evening. The average maximal blood alcohol alcohol consumption, i.e., the intake of moderate concentration was 1.1%0 (110 mg/dl). In 24 nor- amounts during evening hours after or with dinner. The present study was designed t o examine the molipidemic subjects, alcohol caused a detlnite nocturnal hypertriglyceridemia and hyperinsulin- nocturnal and morning serum triglyceride and emia, the mean maximal rise of serum triglyceride plasma insulin responses to moderate drinking of being 1.00 mM above the corresponding value for the alcohol in the evening in normolipidemic and control night. In most cases the elevated triglyceride hyperlipidemic subjects. levels persisted until 8 a.m. next morning and 25% of the subjects would have been diagnosed as having a type IV hyperlipoproteinemia on the basis of STUDY POPULATION these morning triglyceride values, taken after 11 hours’ overnight fast. In 10 patients with primary Twenty-four healthy normolipidemic volunteers (age endogenous hypertriglyceridemia the mean maximal 20-33 years) and ten hyperlipidemic patients (age 22-42 years) participated in the study. All normal volunteers had increase of serum triglyceride after ethanol was 3.65 a fasting serum triglyceride level of less than 1.6 mM. mM and the average morning triglyceride value was Three of these subjects were obese (2637% over ideal still 2.40 mM higher than the corresponding level body weight). The serum triglyceride level of the hyafter a sober evening. There was a highly significant perlipidemic patients varied from 1.9 to 11.8 mM (mean correlation between the serum triglyceride and 4.9k 1.5);six had a type IV and four a type 11-b hyperlipoplasma insulin responses to ethanol (r=+O.S8, proteinemia. Three of the patients were obese. p
Nocturnal H ypertriglyceridemia and H yperinsulinemia Following Moderate Evening Intake of Alcohol Marja-Riitta Taskinen and Esko A. Nikkila From Third Department of Medicine, University Hospital, Helsinki, Finland
ABSTRACT. The study was made to determine is known about the factors which determine the whether a moderate intake of alcohol in the evening individual serum triglyceride response to alcohol. influences the serum triglyceride and plasma insulin In most studies alcohol has been administered to levels during the night and in the following morning. experimental subjects after an overnight fast (2, 11. Ethanol (1.5 g/kg) was given orally between 5 and 9 13, 18,22) or as repeated small doses over a day ( 6 , p.m. to 34 subjects. The serum triglyceride and 17) and there is little if any information on the mode plasma insulin levels were followed during the night and the values compared with those taken after a of response to the most usual pattern of social sober evening. The average maximal blood alcohol alcohol consumption, i.e., the intake of moderate concentration was 1.1%0 (110 mg/dl). In 24 nor- amounts during evening hours after or with dinner. The present study was designed t o examine the molipidemic subjects, alcohol caused a detlnite nocturnal hypertriglyceridemia and hyperinsulin- nocturnal and morning serum triglyceride and emia, the mean maximal rise of serum triglyceride plasma insulin responses to moderate drinking of being 1.00 mM above the corresponding value for the alcohol in the evening in normolipidemic and control night. In most cases the elevated triglyceride hyperlipidemic subjects. levels persisted until 8 a.m. next morning and 25% of the subjects would have been diagnosed as having a type IV hyperlipoproteinemia on the basis of STUDY POPULATION these morning triglyceride values, taken after 11 hours’ overnight fast. In 10 patients with primary Twenty-four healthy normolipidemic volunteers (age endogenous hypertriglyceridemia the mean maximal 20-33 years) and ten hyperlipidemic patients (age 22-42 years) participated in the study. All normal volunteers had increase of serum triglyceride after ethanol was 3.65 a fasting serum triglyceride level of less than 1.6 mM. mM and the average morning triglyceride value was Three of these subjects were obese (2637% over ideal still 2.40 mM higher than the corresponding level body weight). The serum triglyceride level of the hyafter a sober evening. There was a highly significant perlipidemic patients varied from 1.9 to 11.8 mM (mean correlation between the serum triglyceride and 4.9k 1.5);six had a type IV and four a type 11-b hyperlipoplasma insulin responses to ethanol (r=+O.S8, proteinemia. Three of the patients were obese. p
