STRESS AND IL ON HPA AND HPG AXIS OF PVN-LESIONED RATS tems in the medial preoptic area. Brain Res 375:49-56 43. Valentino RJ 1989 Corticotropin-releasing factor: a putative neurotransmitter in the noradrenergic nucleus locus ceruleus. Psychopharmacol Bull 25:306-312 44. Feng YJ, Shalts E, Xia L, Rivier J, Rivier C, Vale W, Ferin M 1991 An inhibitory effect of interleukin-la on basal gonadotropin release in the ovariectomized rhesus monkey: reversal by a corticotropin-releasing factor antagonist. Endocrinology 128:2077-2082 45. Chen W-P, Witkin JW, Silverman A-J 1990 Sexual dimorphism
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in the synaptic input to gonadotropin releasing hormone neurons. Endocrinology 126:695-702 46. Chen W-P, Witkin JW, Silverman A-J 1989 Beta-endorphin and gonadotropin-releasing hormone synaptic input to gonadotropinreleasing hormone neurosecretory cells in the male rat. J Comp Neurol 286:85-95 47. Leranth C, MacLusky NJ, Shanabrough M, Naftolin F 1988 Immunohistochemical evidence for synaptic connections between proopiomenalocortin-immunoreactive axons and LH-RH neurons in the preoptic area of the rat. Brain Res 449:167-176
Nomenclature Clarification for the Bovine Placental Prolactin-Related Hormones LINDA A. SCHULER, MARK A. KESSLER, MINORU TANAKA, AND KUNIO NAKASHIMA Department of Comparative Biosciences (L.A.S., M.A.K.), University of Wisconsin, Madison, Wisconsin 53706; and Department of Biochemistry (M.T., K.N.), Mie University School of Medicine, Edobashi 2-174, Tsu, Mie 514, Japan
The bovine placenta expresses multiple genes related to the pituitary hormone, PRL. Bovine placental lactogen (bPL) was originally identified and isolated by virtue of its ability to bind to rabbit PRL receptors (1-3). Subsequent amino acid sequence analysis, and molecular cloning of the cDNA revealed two proteins, identical except for their amino terminus (4, 5). Another distinct
subfamily of placental transcripts predicting secreted glycoproteins similar in structure to bPL and PRL, but quite different in amino acid sequence, has been identified using low stringency hybridization (5-9). At least one of these is also expressed (10). The function of these related placental hormones during pregnancy is not known; however, by analogy to PRL and GH, they may be involved in a variety of processes in mother and fetus. Here we present a common nomenclature for these hormones: New name bPL-Ala bPL-Val bPRP-I bPRP-II bPRP-III bPRP-IV bPRP-V bPRP-VI
Previous name
Ref
bPL bPLP-I, bPL variant bPRC-I bPRC-II bPRC-III bPLP-II bPLP-III bPLP-IV
(4) (5) (9) (8) (8) (5) (6) (7)
References 1. Murthy GS, Schellenberg C, Friesen HG 1982 Purification and characterization of bovine placental lactogen. Endocrinology 111:2117-2124 2. Beckers JF, Fromont-Lienard C, VanDerZwalmen P, Ectors F, Wouters-Ballman P 1980 Isolement d'une hormone placentaire bovine presentant une activite. Ann Med Vet 124:585-595 3. Eakle KA, Arima Y, Swanson P, Grimek H, Bremel RD 1982 A 32,000-molecular weight protein from the bovine placenta with placental lactogen-like activity in radioreceptor assay. Endocrinology 110:1758-1765 4. Schuler LA, Shimomura K, Kessler MA, Zieler CG, Bremel RD 1988 Bovine placental lactogen: molecular cloning and protein structure. Biochemistry 27:8443-8448 5. Yamakawa M, Tanaka M, Koyama M, Kagesato Y, Watahiki M, Yamamoto M, Nakashima K 1990 Expression of new members of the prolactin growth hormone gene family in bovine placenta. J Biol Chem 265:8915-8920 6. Tanaka M, Yamakawa M, Watahiki M, Yamamoto M, Nakashima K 1989 Isolation of a novel prolactin-like cDNA clone from bovine placenta: occurrence of new family members. Biochim Biophys Acta 1008:193-197 7. Tanaka M, Minoura H, Ushiro H, Nakashima K 1991 A novel cDNA clone encoding a prolactin-like protein that lacks the two C-terminal cysteine residues isolated from bovine placenta. Biochim Biophys Acta 1088:385-389 8. Kessler MA, Milosavljevic M, Zieler CG, Schuler LA 1989 A subfamily of bovine prolactin-related transcripts distinct from placental lactogen in the fetal placenta. Biochemistry 28:51545161 9. Schuler LA, Hurley WL 1987 Molecular cloning of a prolactinrelated mRNA expressed in bovine placenta. Proc Natl Acad Sci USA 84:5650-5654 10. Zieler CG, Kessler MA, Schuler LA 1990 Characterization of a novel prolactin-related protein from bovine fetal placenta. Endocrinology 126:2377-2382
The Endocrine Society. Downloaded from press.endocrine.org by [${individualUser.displayName}] on 16 November 2015. at 20:29 For personal use only. No other uses without permission. . All rights reserved.
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in the synaptic input to gonadotropin releasing hormone neurons. Endocrinology 126:695-702 46. Chen W-P, Witkin JW, Silverman A-J 1989 Beta-endorphin and gonadotropin-releasing hormone synaptic input to gonadotropinreleasing hormone neurosecretory cells in the male rat. J Comp Neurol 286:85-95 47. Leranth C, MacLusky NJ, Shanabrough M, Naftolin F 1988 Immunohistochemical evidence for synaptic connections between proopiomenalocortin-immunoreactive axons and LH-RH neurons in the preoptic area of the rat. Brain Res 449:167-176
Nomenclature Clarification for the Bovine Placental Prolactin-Related Hormones LINDA A. SCHULER, MARK A. KESSLER, MINORU TANAKA, AND KUNIO NAKASHIMA Department of Comparative Biosciences (L.A.S., M.A.K.), University of Wisconsin, Madison, Wisconsin 53706; and Department of Biochemistry (M.T., K.N.), Mie University School of Medicine, Edobashi 2-174, Tsu, Mie 514, Japan
The bovine placenta expresses multiple genes related to the pituitary hormone, PRL. Bovine placental lactogen (bPL) was originally identified and isolated by virtue of its ability to bind to rabbit PRL receptors (1-3). Subsequent amino acid sequence analysis, and molecular cloning of the cDNA revealed two proteins, identical except for their amino terminus (4, 5). Another distinct
subfamily of placental transcripts predicting secreted glycoproteins similar in structure to bPL and PRL, but quite different in amino acid sequence, has been identified using low stringency hybridization (5-9). At least one of these is also expressed (10). The function of these related placental hormones during pregnancy is not known; however, by analogy to PRL and GH, they may be involved in a variety of processes in mother and fetus. Here we present a common nomenclature for these hormones: New name bPL-Ala bPL-Val bPRP-I bPRP-II bPRP-III bPRP-IV bPRP-V bPRP-VI
Previous name
Ref
bPL bPLP-I, bPL variant bPRC-I bPRC-II bPRC-III bPLP-II bPLP-III bPLP-IV
(4) (5) (9) (8) (8) (5) (6) (7)
References 1. Murthy GS, Schellenberg C, Friesen HG 1982 Purification and characterization of bovine placental lactogen. Endocrinology 111:2117-2124 2. Beckers JF, Fromont-Lienard C, VanDerZwalmen P, Ectors F, Wouters-Ballman P 1980 Isolement d'une hormone placentaire bovine presentant une activite. Ann Med Vet 124:585-595 3. Eakle KA, Arima Y, Swanson P, Grimek H, Bremel RD 1982 A 32,000-molecular weight protein from the bovine placenta with placental lactogen-like activity in radioreceptor assay. Endocrinology 110:1758-1765 4. Schuler LA, Shimomura K, Kessler MA, Zieler CG, Bremel RD 1988 Bovine placental lactogen: molecular cloning and protein structure. Biochemistry 27:8443-8448 5. Yamakawa M, Tanaka M, Koyama M, Kagesato Y, Watahiki M, Yamamoto M, Nakashima K 1990 Expression of new members of the prolactin growth hormone gene family in bovine placenta. J Biol Chem 265:8915-8920 6. Tanaka M, Yamakawa M, Watahiki M, Yamamoto M, Nakashima K 1989 Isolation of a novel prolactin-like cDNA clone from bovine placenta: occurrence of new family members. Biochim Biophys Acta 1008:193-197 7. Tanaka M, Minoura H, Ushiro H, Nakashima K 1991 A novel cDNA clone encoding a prolactin-like protein that lacks the two C-terminal cysteine residues isolated from bovine placenta. Biochim Biophys Acta 1088:385-389 8. Kessler MA, Milosavljevic M, Zieler CG, Schuler LA 1989 A subfamily of bovine prolactin-related transcripts distinct from placental lactogen in the fetal placenta. Biochemistry 28:51545161 9. Schuler LA, Hurley WL 1987 Molecular cloning of a prolactinrelated mRNA expressed in bovine placenta. Proc Natl Acad Sci USA 84:5650-5654 10. Zieler CG, Kessler MA, Schuler LA 1990 Characterization of a novel prolactin-related protein from bovine fetal placenta. Endocrinology 126:2377-2382
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