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Cardiac risk factors and prevention
ORIGINAL ARTICLE
Non-alcoholic fatty liver disease, metabolic syndrome and subclinical cardiovascular changes in the general population Nan Hee Kim,1 Juri Park,2 Seong Hwan Kim,3 Yong Hyun Kim,3 Dong Hyuk Kim,3 Goo-Yeong Cho,4 Inkyung Baik,5 Hong Euy Lim,6 Eung Ju Kim,6 Jin Oh Na,6 Jung Bok Lee,7 Seung Ku Lee,8 Chol Shin8 For numbered affiliations see end of article. Correspondence to Professor Seong Hwan Kim, Division of Cardiology, Department of Medicine, Korea University Ansan Hospital, 516 Gojan-1-dong, Danwon-gu, Ansan-si, Gyeonggi-do 425-707, Korea; [email protected] NHK and JP contributed equally to this study. Received 15 October 2013 Revised 20 February 2014 Accepted 19 March 2014 Published Online First 10 April 2014
ABSTRACT Objective The effect of non-alcoholic fatty liver disease (NAFLD) on cardiovascular system remains controversial. We investigated the independent contribution of NAFLD to cardiovascular structure and function in the general population. Methods A total of 1886 participants without known cardiovascular disease were enrolled from the Korean Genome Epidemiology Study. The participants were divided into four groups, based on the presence of NAFLD, metabolic syndrome (MetS), neither or both. NAFLD was diagnosed by CT. Changes in cardiovascular structure and function were assessed by tissue Doppler imaging (TDI) echocardiography, carotid ultrasound and brachial-ankle pulse wave velocity (baPWV). Results In multivariate analyses, subjects with both NAFLD and MetS had a higher E/Ea ratio and baPWV, as well as a lower TDI Ea velocity (all p
Cardiac risk factors and prevention
ORIGINAL ARTICLE
Non-alcoholic fatty liver disease, metabolic syndrome and subclinical cardiovascular changes in the general population Nan Hee Kim,1 Juri Park,2 Seong Hwan Kim,3 Yong Hyun Kim,3 Dong Hyuk Kim,3 Goo-Yeong Cho,4 Inkyung Baik,5 Hong Euy Lim,6 Eung Ju Kim,6 Jin Oh Na,6 Jung Bok Lee,7 Seung Ku Lee,8 Chol Shin8 For numbered affiliations see end of article. Correspondence to Professor Seong Hwan Kim, Division of Cardiology, Department of Medicine, Korea University Ansan Hospital, 516 Gojan-1-dong, Danwon-gu, Ansan-si, Gyeonggi-do 425-707, Korea; [email protected] NHK and JP contributed equally to this study. Received 15 October 2013 Revised 20 February 2014 Accepted 19 March 2014 Published Online First 10 April 2014
ABSTRACT Objective The effect of non-alcoholic fatty liver disease (NAFLD) on cardiovascular system remains controversial. We investigated the independent contribution of NAFLD to cardiovascular structure and function in the general population. Methods A total of 1886 participants without known cardiovascular disease were enrolled from the Korean Genome Epidemiology Study. The participants were divided into four groups, based on the presence of NAFLD, metabolic syndrome (MetS), neither or both. NAFLD was diagnosed by CT. Changes in cardiovascular structure and function were assessed by tissue Doppler imaging (TDI) echocardiography, carotid ultrasound and brachial-ankle pulse wave velocity (baPWV). Results In multivariate analyses, subjects with both NAFLD and MetS had a higher E/Ea ratio and baPWV, as well as a lower TDI Ea velocity (all p
