ANNUAL REVIEWS

Further

Quick links to online content Ann. Rev. Pharmacol. Toxicol. 1979. 19:469-90 Copyright © 1979 by Annual Reviews Inc. All rights reserved

Annu. Rev. Pharmacol. Toxicol. 1979.19:469-490. Downloaded from www.annualreviews.org by University of Minnesota - Twin Cities on 09/06/13. For personal use only.

NONSTEROIDAL

.6750

ANTI-INFLAMMATORY AGENTS Rodney Nickander Department of Immunology and Connective Tissue Research, The Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana

46206

F. Gilbert McMahon Department of Medicine, Tulane

1430

University

School of Medicine,

Tulane Avenue, New Orleans, Louisiana

70112

Anthony S. Ridoifo Clinical Research Division, The Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana

46206

INTRODUCTION

Nonsteroidal anti-inflammatory agents (NSAIA) have as their major phar­ macological effect the reduction of edema, erythema, and resulting tissue damage associated with inflammatory conditions, but many also share the actions of analgesia and antipyresis. This triad of action-anti-inflamma­ tory, analgesic, and antipyretic-