American Journal of Transplantation 2015; 15: 1666–1673 Wiley Periodicals Inc.
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Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons doi: 10.1111/ajt.13159
Obstetric and Neonatal Outcome of Pregnancies Fathered by Males on Immunosuppression After Solid Organ Transplantation N.-H. Morken1,2,3,*, C. Diaz-Garcia4, A. V. Reisaeter5, A. Foss6, T. Leivestad5, O. Geiran7,8, D. Herva´s9 and M. Bra¨nnstro¨m10 1
Department of Clinical Sciences, University of Bergen, Norway 2 Department of Global Public Health and Primary Care, University of Bergen, Norway 3 Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway 4 Department of Gynecology and Obstetrics, La Fe University Hospital and Instituto de Investigacio´n Sanitaria La Fe, University of Valencia, Spain 5 The Norwegian Renal Registry, Oslo, Norway 6 Department of Transplantation Medicine, Rikshospitalet, Oslo University Hospital, Norway 7 Institute of Clinical Medicine, University of Oslo, Norway 8 Department of Cardio-Thoracic Surgery, Rikshospitalet, Oslo University Hospital, Norway 9 Biostatistics Unit, Instituto de Investigacio´n Sanitaria La Fe, University of Valencia, Spain 10 Department of Obstetrics & Gynecology, Sahlgrenska Academy, University of Gothenburg, Sweden Corresponding author: Nils-Halvdan Morken, [email protected]
Immunosuppressive drugs may influence spermatogenesis, but little is known about outcome of pregnancies fathered by transplanted males. We estimated risk of adverse outcomes in pregnancies (with data after the first trimester) fathered by males that had undergone organ transplantation and were treated with immunosuppression. A population-based study, linking data from the Norwegian transplant registry and the Medical Birth Registry of Norway during 1967–2009 was designed. All Norwegian men undergoing solid organ transplantation were included. Odds ratios for major malformations, preeclampsia, preterm delivery (
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Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons doi: 10.1111/ajt.13159
Obstetric and Neonatal Outcome of Pregnancies Fathered by Males on Immunosuppression After Solid Organ Transplantation N.-H. Morken1,2,3,*, C. Diaz-Garcia4, A. V. Reisaeter5, A. Foss6, T. Leivestad5, O. Geiran7,8, D. Herva´s9 and M. Bra¨nnstro¨m10 1
Department of Clinical Sciences, University of Bergen, Norway 2 Department of Global Public Health and Primary Care, University of Bergen, Norway 3 Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway 4 Department of Gynecology and Obstetrics, La Fe University Hospital and Instituto de Investigacio´n Sanitaria La Fe, University of Valencia, Spain 5 The Norwegian Renal Registry, Oslo, Norway 6 Department of Transplantation Medicine, Rikshospitalet, Oslo University Hospital, Norway 7 Institute of Clinical Medicine, University of Oslo, Norway 8 Department of Cardio-Thoracic Surgery, Rikshospitalet, Oslo University Hospital, Norway 9 Biostatistics Unit, Instituto de Investigacio´n Sanitaria La Fe, University of Valencia, Spain 10 Department of Obstetrics & Gynecology, Sahlgrenska Academy, University of Gothenburg, Sweden Corresponding author: Nils-Halvdan Morken, [email protected]
Immunosuppressive drugs may influence spermatogenesis, but little is known about outcome of pregnancies fathered by transplanted males. We estimated risk of adverse outcomes in pregnancies (with data after the first trimester) fathered by males that had undergone organ transplantation and were treated with immunosuppression. A population-based study, linking data from the Norwegian transplant registry and the Medical Birth Registry of Norway during 1967–2009 was designed. All Norwegian men undergoing solid organ transplantation were included. Odds ratios for major malformations, preeclampsia, preterm delivery (
