Age and Ageing Advance Access published December 13, 2014 Age and Ageing 2014; 0: 1–6 doi: 10.1093/ageing/afu198
© The Author 2014. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: [email protected]
Older age is a strong predictor for poor outcome in intracerebral haemorrhage: the INTERACT2 study KARIN RÅDHOLM1, HISATOMI ARIMA2, RICHARD I. LINDLEY2, JIGUANG WANG3, CHRISTOPHE TZOURIO4,5, THOMPSON ROBINSON6, EMMA HEELEY2, CRAIG S. ANDERSON2, JOHN CHALMERS2, FOR THE INTERACT2 INVESTIGATORS† 1
Division of Community Medicine, Primary Care, Department of Medicine and Health Sciences, Faculty of Health Sciences, Department of Local Care West, Linköping University, County Council of Östergötland, Linköping, Sweden 2 The George Institute for Global Health, University of Sydney and Royal Prince Alfred Hospital, NSW, Australia 3 The Shanghai Institute of Hypertension, Rui Jin Hospital, Shanghai Jiaotong University, Shanghai, China 4 INSERM U897, Bordeaux, France 5 University of Bordeaux, Bordeaux, France 6 The Department of Cardiovascular Sciences and NIHR Biomedical Research Unit in Cardiovascular Disease, University of Leicester, Leicester, UK Address correspondence to: H. Arima, The George Institute for Global Health, PO Box M201, Missenden Road, NSW 2050, Australia. Tel: (+61) 2 9993 4500; Fax: (+61) 2 9993 4502. Email: [email protected]
Abstract Background and purpose: Global ageing contributes greatly to the burden of stroke. We investigated the influence of age on the baseline profile and on outcomes in acute intracerebral haemorrhage (ICH) among participants of the INTERACT2 study. Methods: INTERACT2 was an international, randomised controlled trial in 2839 patients with spontaneous ICH within 6 h of onset and elevated systolic blood pressure (SBP; 150–220 mmHg) who were allocated to receive intensive (target SBP
© The Author 2014. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: [email protected]
Older age is a strong predictor for poor outcome in intracerebral haemorrhage: the INTERACT2 study KARIN RÅDHOLM1, HISATOMI ARIMA2, RICHARD I. LINDLEY2, JIGUANG WANG3, CHRISTOPHE TZOURIO4,5, THOMPSON ROBINSON6, EMMA HEELEY2, CRAIG S. ANDERSON2, JOHN CHALMERS2, FOR THE INTERACT2 INVESTIGATORS† 1
Division of Community Medicine, Primary Care, Department of Medicine and Health Sciences, Faculty of Health Sciences, Department of Local Care West, Linköping University, County Council of Östergötland, Linköping, Sweden 2 The George Institute for Global Health, University of Sydney and Royal Prince Alfred Hospital, NSW, Australia 3 The Shanghai Institute of Hypertension, Rui Jin Hospital, Shanghai Jiaotong University, Shanghai, China 4 INSERM U897, Bordeaux, France 5 University of Bordeaux, Bordeaux, France 6 The Department of Cardiovascular Sciences and NIHR Biomedical Research Unit in Cardiovascular Disease, University of Leicester, Leicester, UK Address correspondence to: H. Arima, The George Institute for Global Health, PO Box M201, Missenden Road, NSW 2050, Australia. Tel: (+61) 2 9993 4500; Fax: (+61) 2 9993 4502. Email: [email protected]
Abstract Background and purpose: Global ageing contributes greatly to the burden of stroke. We investigated the influence of age on the baseline profile and on outcomes in acute intracerebral haemorrhage (ICH) among participants of the INTERACT2 study. Methods: INTERACT2 was an international, randomised controlled trial in 2839 patients with spontaneous ICH within 6 h of onset and elevated systolic blood pressure (SBP; 150–220 mmHg) who were allocated to receive intensive (target SBP
