doi: 10.1111/jop.12266
J Oral Pathol Med © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd wileyonlinelibrary.com/journal/jop
REVIEW ARTICLE
Oral complications and dental care in children with acute lymphoblastic leukaemia Marie-Cecile Valera1,2,3, Emmanuelle Noirrit-Esclassan1,2, Marlene Pasquet4,5, Frederic Vaysse1,2 1
Universite Paul Sabatier, Toulouse III, France; 2CHU de Toulouse, Service d’odontologie pediatrique, Toulouse, France; 3INSERM U1048, I2MC, Toulouse, France; 4CHU Toulouse, Service d’hematologie pediatrique, Toulouse, France; 5INSERM U1037, CRCT Equipe 16, Toulouse, France
Acute leukaemia is the most common type of childhood cancer, the acute lymphoblastic type accounting for the majority of cases. Children affected by leukaemia receive various forms of treatments including chemotherapeutic agents and stem cell transplants. Leukaemia and its treatment can directly or indirectly affect oral health and further dental treatments. The oral complications include mucositis, opportunistic infections, gingival inflammation and bleeding, xerostomia and carious lesions. An additional consideration in children is the impact of the treatments on the developing dentition and on orofacial growth. The aim of this review is to describe the oral complications in children with acute lymphoblastic leukaemia and the methods of prevention and management before, during and after the cancer treatment. J Oral Pathol Med (2014) Keywords: acute lymphoblastic leukaemia; dental care
Acute lymphoblastic leukaemia Epidemiology Leukaemia is the most common paediatric malignancy accounting for about 30% of all paediatric cancers diagnosed for children
J Oral Pathol Med © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd wileyonlinelibrary.com/journal/jop
REVIEW ARTICLE
Oral complications and dental care in children with acute lymphoblastic leukaemia Marie-Cecile Valera1,2,3, Emmanuelle Noirrit-Esclassan1,2, Marlene Pasquet4,5, Frederic Vaysse1,2 1
Universite Paul Sabatier, Toulouse III, France; 2CHU de Toulouse, Service d’odontologie pediatrique, Toulouse, France; 3INSERM U1048, I2MC, Toulouse, France; 4CHU Toulouse, Service d’hematologie pediatrique, Toulouse, France; 5INSERM U1037, CRCT Equipe 16, Toulouse, France
Acute leukaemia is the most common type of childhood cancer, the acute lymphoblastic type accounting for the majority of cases. Children affected by leukaemia receive various forms of treatments including chemotherapeutic agents and stem cell transplants. Leukaemia and its treatment can directly or indirectly affect oral health and further dental treatments. The oral complications include mucositis, opportunistic infections, gingival inflammation and bleeding, xerostomia and carious lesions. An additional consideration in children is the impact of the treatments on the developing dentition and on orofacial growth. The aim of this review is to describe the oral complications in children with acute lymphoblastic leukaemia and the methods of prevention and management before, during and after the cancer treatment. J Oral Pathol Med (2014) Keywords: acute lymphoblastic leukaemia; dental care
Acute lymphoblastic leukaemia Epidemiology Leukaemia is the most common paediatric malignancy accounting for about 30% of all paediatric cancers diagnosed for children
