RESEARCH ARTICLE

Oral Microbiota in Infants Fed a Formula Supplemented with Bovine Milk Fat Globule Membranes - A Randomized Controlled Trial Niklas Timby1*, Magnus Domello¨f1, Pernilla Lif Holgerson2, Christina E. West1, Bo Lo¨nnerdal3, Olle Hernell1, Ingegerd Johansson4

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OPEN ACCESS Citation: Timby N, Domello¨f M, Holgerson PL, West CE, Lo¨nnerdal B, Hernell O, et al. (2017) Oral Microbiota in Infants Fed a Formula Supplemented with Bovine Milk Fat Globule Membranes - A Randomized Controlled Trial. PLoS ONE 12(1): e0169831. doi:10.1371/journal.pone.0169831 Editor: Nursen Topcuoglu, Istanbul Universitesi Dis Hekimligi Fakultesi, TURKEY

1 Department of Clinical Sciences/Unit of Pediatrics, Umeå University, Umeå, Sweden, 2 Department of Odontology/Unit of Pedodontics, Umeå University, Umeå, Sweden, 3 Department of Nutrition, University of California, Davis, United States of America, 4 Department of Odontology/Unit of Cariology, Umeå University, Umeå, Sweden * [email protected]

Abstract Background In a recent study, supplementation of infant formula with milk fat globule membranes (MFGM) decreased the incidence of otitis media in infants