Can J Diabetes 38 (2014) 307e313
Contents lists available at ScienceDirect
Canadian Journal of Diabetes journal homepage: www.canadianjournalofdiabetes.com
Original Research
Osteocalcin is Higher Across Pregnancy in Caucasian Women with Gestational Diabetes Mellitus Negar Tabatabaei PhD a, Yves Giguère MD, PhD b, Jean-Claude Forest MD, PhD b, Celia J. Rodd MD, MSc c, Richard Kremer MD, PhD d, Hope A. Weiler RD, PhD a, * a
School of Dietetics and Human Nutrition, McGill University, Ste-Anne-de-Bellevue, Quebec, Canada Centre Hospitalier Universitaire de Québec Research Centre et Faculté de médecine, Université Laval, Québec City, Quebec, Canada c Department of Pediatrics, Montreal Children’s Hospital, McGill University, Montreal, Quebec, Canada d Department of Medicine, Calcium Research Laboratory, McGill University, Montreal, Quebec, Canada b
a r t i c l e i n f o
a b s t r a c t
Article history: Received 14 February 2013 Received in revised form 9 February 2014 Accepted 11 February 2014
Objective: The purpose of this study was to investigate circulating concentrations of osteocalcin, a bonederived protein, while accounting for 25-hydroxyvitamin D (25(OH)D) throughout pregnancy, and whether early gestation concentrations and changes in osteocalcin predict the subsequent diagnosis of gestational diabetes mellitus (GDM). Methods: This was a nested case-control study involving 48 GDM and 48 control pregnant Caucasian women (matched for age, season of conception, pre-pregnancy body mass index and pregnancy length). Maternal serum osteocalcin was measured by enzyme-linked immunosorbent assay and 25(OH)D by chemiluminescence throughout pregnancy (11e13 weeks, 24e28 weeks and predelivery). Differences between groups were compared by mixed model analysis of variance. Predictors of diagnosis of GDM were explored using generalized estimating equation models. Neonatal general health outcomes were also compared between groups. Results: Serum osteocalcin was higher across pregnancy (p¼0.006) in women with GDM vs. controls, whereas serum 25(OH)D was not different (p¼0.80). Both biomarkers increased with time across pregnancy (p
Contents lists available at ScienceDirect
Canadian Journal of Diabetes journal homepage: www.canadianjournalofdiabetes.com
Original Research
Osteocalcin is Higher Across Pregnancy in Caucasian Women with Gestational Diabetes Mellitus Negar Tabatabaei PhD a, Yves Giguère MD, PhD b, Jean-Claude Forest MD, PhD b, Celia J. Rodd MD, MSc c, Richard Kremer MD, PhD d, Hope A. Weiler RD, PhD a, * a
School of Dietetics and Human Nutrition, McGill University, Ste-Anne-de-Bellevue, Quebec, Canada Centre Hospitalier Universitaire de Québec Research Centre et Faculté de médecine, Université Laval, Québec City, Quebec, Canada c Department of Pediatrics, Montreal Children’s Hospital, McGill University, Montreal, Quebec, Canada d Department of Medicine, Calcium Research Laboratory, McGill University, Montreal, Quebec, Canada b
a r t i c l e i n f o
a b s t r a c t
Article history: Received 14 February 2013 Received in revised form 9 February 2014 Accepted 11 February 2014
Objective: The purpose of this study was to investigate circulating concentrations of osteocalcin, a bonederived protein, while accounting for 25-hydroxyvitamin D (25(OH)D) throughout pregnancy, and whether early gestation concentrations and changes in osteocalcin predict the subsequent diagnosis of gestational diabetes mellitus (GDM). Methods: This was a nested case-control study involving 48 GDM and 48 control pregnant Caucasian women (matched for age, season of conception, pre-pregnancy body mass index and pregnancy length). Maternal serum osteocalcin was measured by enzyme-linked immunosorbent assay and 25(OH)D by chemiluminescence throughout pregnancy (11e13 weeks, 24e28 weeks and predelivery). Differences between groups were compared by mixed model analysis of variance. Predictors of diagnosis of GDM were explored using generalized estimating equation models. Neonatal general health outcomes were also compared between groups. Results: Serum osteocalcin was higher across pregnancy (p¼0.006) in women with GDM vs. controls, whereas serum 25(OH)D was not different (p¼0.80). Both biomarkers increased with time across pregnancy (p
