Tumor Biol. (2016) 37:3349–3357 DOI 10.1007/s13277-015-4148-x
ORIGINAL ARTICLE
Overexpression of acylglycerol kinase is associated with poorer prognosis and lymph node metastasis in nasopharyngeal carcinoma Qian Zhu 1,4 & Su-Mei Cao 2,4 & Huan-Xin Lin 3,4 & Qi Yang 1,4 & Sai-Lan Liu 1,4 & Ling Guo 1,4
Received: 20 July 2015 / Accepted: 23 September 2015 / Published online: 7 October 2015 # The Author(s) 2015. This article is published with open access at Springerlink.com
Abstract Acylglycerol kinase (AGK) has been reported to promote a malignant phenotype and enhance the development of cancer stem cells. However, the clinical value of AGK in cancer remains unclear. This study aimed to investigate the expression and clinicopathological significance of AGK in nasopharyngeal carcinoma (NPC). AGK was significantly upregulated in NPC cell lines and clinical specimens as indicated by real-time PCR and Western blotting. Among the AGKpositive cases, 52/114 (45.6 %) of the archived human NPC specimens expressed high levels of AGK. High expression of AGK was associated with significantly shorter overall and disease-free survival (P
ORIGINAL ARTICLE
Overexpression of acylglycerol kinase is associated with poorer prognosis and lymph node metastasis in nasopharyngeal carcinoma Qian Zhu 1,4 & Su-Mei Cao 2,4 & Huan-Xin Lin 3,4 & Qi Yang 1,4 & Sai-Lan Liu 1,4 & Ling Guo 1,4
Received: 20 July 2015 / Accepted: 23 September 2015 / Published online: 7 October 2015 # The Author(s) 2015. This article is published with open access at Springerlink.com
Abstract Acylglycerol kinase (AGK) has been reported to promote a malignant phenotype and enhance the development of cancer stem cells. However, the clinical value of AGK in cancer remains unclear. This study aimed to investigate the expression and clinicopathological significance of AGK in nasopharyngeal carcinoma (NPC). AGK was significantly upregulated in NPC cell lines and clinical specimens as indicated by real-time PCR and Western blotting. Among the AGKpositive cases, 52/114 (45.6 %) of the archived human NPC specimens expressed high levels of AGK. High expression of AGK was associated with significantly shorter overall and disease-free survival (P
