Int J Clin Exp Med 2015;8(11):21599-21604 www.ijcem.com /ISSN:1940-5901/IJCEM0013445
Original Article Paraoxonase-1 and arylesterase activities in patients with colorectal cancer Cigdem Usul Afsar1, Meral Gunaldı2, Yıldız Okuturlar3, Asuman Gedikbası4, Elif Eda Tiken5, Sibel Kahraman6, Feryal Karaca7, Vehbi Ercolak8, Mehmet Karabulut9 Department of Medical Oncology, Istanbul Education and Research Hospital, Istanbul, Turkey; 2Department of Medical Oncology, 3Department of Internal Medicine, 4Department of Biochemistry, 5Department of Radiation Oncology, 6Department of Pathology, Bakırkoy Dr Sadi Konuk Education and Research Hospital, Istanbul, Turkey; 7 Department of Radiation Oncology, Adana Numune Training and Research Hospital, Adana, Turkey; 8Department of Medical Oncology, Mersin Government Hospital, Mersin, Turkey; 9Department of General Surgery, Bakırkoy Dr Sadi Konuk Education and Research Hospital, Istanbul, Turkey 1
Received April 19, 2015; Accepted October 19, 2015; Epub November 15, 2015; Published November 30, 2015 Abstract: Background: The aim of this study was to evaluate paraoxonase-1 (PON1) and arylesterase (ARE) activities and oxidative stress status in patients with colorectal carcinomas (CRC). Materials and methods: Thirty-three patients (20 male, 13 female) with CRC and 30 healthy controls were enrolled in the study. Blood samples were obtained from the CRC patients before adjuvant therapy. Serum samples from CRC patients and healthy controls were analyzed for PON1 and ARE activities. Results: The PON1 and ARE activities of the patients with CRC were significantly higher compared to those of the control group (PON1 activity is 125.35±20.07 U/L for CRC patients and 1.22±0.48 U/L for control group, P
Original Article Paraoxonase-1 and arylesterase activities in patients with colorectal cancer Cigdem Usul Afsar1, Meral Gunaldı2, Yıldız Okuturlar3, Asuman Gedikbası4, Elif Eda Tiken5, Sibel Kahraman6, Feryal Karaca7, Vehbi Ercolak8, Mehmet Karabulut9 Department of Medical Oncology, Istanbul Education and Research Hospital, Istanbul, Turkey; 2Department of Medical Oncology, 3Department of Internal Medicine, 4Department of Biochemistry, 5Department of Radiation Oncology, 6Department of Pathology, Bakırkoy Dr Sadi Konuk Education and Research Hospital, Istanbul, Turkey; 7 Department of Radiation Oncology, Adana Numune Training and Research Hospital, Adana, Turkey; 8Department of Medical Oncology, Mersin Government Hospital, Mersin, Turkey; 9Department of General Surgery, Bakırkoy Dr Sadi Konuk Education and Research Hospital, Istanbul, Turkey 1
Received April 19, 2015; Accepted October 19, 2015; Epub November 15, 2015; Published November 30, 2015 Abstract: Background: The aim of this study was to evaluate paraoxonase-1 (PON1) and arylesterase (ARE) activities and oxidative stress status in patients with colorectal carcinomas (CRC). Materials and methods: Thirty-three patients (20 male, 13 female) with CRC and 30 healthy controls were enrolled in the study. Blood samples were obtained from the CRC patients before adjuvant therapy. Serum samples from CRC patients and healthy controls were analyzed for PON1 and ARE activities. Results: The PON1 and ARE activities of the patients with CRC were significantly higher compared to those of the control group (PON1 activity is 125.35±20.07 U/L for CRC patients and 1.22±0.48 U/L for control group, P
