Parental acceptance of minimally invasive fetal and neonatal autopsy compared with conventional autopsy Xin Kang1 MD, Teresa Cos1 MD, Meriem Guizani1 MD, Mieke M. Cannie2,3 MD, PhD, Valérie Segers4 MD, and Jacques C. Jani1 MD, PhD Departments of Obstetrics and Gynecology,1 Radiology2 and Foetopathology,4 University Hospital Brugmann, Brussels, Belgium; department of Radiology, 3 UZ Brussel, Vrije Universiteit Brussel, Belgium. Address for correspondance: Professor Jacques C. Jani, MD, PhD, Department of Obstetrics and Gynecology, Fetal Medicine Unit, University Hospital Brugmann, Place A. Van Gehuchten 4, 1020 Brussels , Belgium. Tel: +32 2 477 3631 Fax: + 32 2 477 2932 Email: [email protected] Short title: Parental acceptance of MIA in fetuses and neonates Key words: MIA, minimally invasive, conventional autopsy, MRI, guided biopsy. Word count (excluding abstract and references): 2147 words; Table count 2; Figure count 3; Funding information: this work was partly supported by the Fetal Medicine Foundation Belgium. Xin Kang is a recipient of a grant from the Brugmann Foundation. There are no conflict of interest This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/pd.4435
This article is protected by copyright. All rights reserved.
What’s already known about this topic?
Although the information revealed by conventional autopsy were critical for parental counseling, the autopsy rate is declining. Post-mortem imaging combined with laparoscopic-guided or percutaneous needle biopsies were demonstrated feasible. However the parents’ opinion were unknown.
What does this study add?
Postmortem imaging combined with systematic organ biopsies is highly acceptable amongst all parents independent of their religion and the method used for organ biopsy
This article is protected by copyright. All rights reserved.
Abstract Objective: To determine parental acceptance of minimally invasive autopsy(MIA) involving post-mortem imaging and organ tissue sampling compared with conventional autopsy, and to compare the acceptability of percutaneous versus laparoscopic-guided biopsy.
Methods: Following termination of pregnancy(TOP) parents were offered the option of traditional autopsy and subsequently interviewed about their acceptance of MIA. The McNemar test for paired samples was used to assess the difference in acceptance of MIA and conventional autopsy. The Wilcoxon signed-rank test for paired samples was used to compare the acceptance score for percutaneous versus laparoscopic-guided biopsy. Logistic regression was selected to study the association of parental acceptance of conventional autopsy and MIA with different variables.
Results: Conventional autopsy was accepted by 42(60.0%) of the 70 parents. Regression analysis showed that non-Muslim faith was the only factor significantly associated with acceptance of conventional autopsy(p=0.030). Of 28 parents who initially refused conventional autopsy, 13(46.4%) subsequently accepted MIA, increasing acceptance to 78.6%(p
This article is protected by copyright. All rights reserved.
What’s already known about this topic?
Although the information revealed by conventional autopsy were critical for parental counseling, the autopsy rate is declining. Post-mortem imaging combined with laparoscopic-guided or percutaneous needle biopsies were demonstrated feasible. However the parents’ opinion were unknown.
What does this study add?
Postmortem imaging combined with systematic organ biopsies is highly acceptable amongst all parents independent of their religion and the method used for organ biopsy
This article is protected by copyright. All rights reserved.
Abstract Objective: To determine parental acceptance of minimally invasive autopsy(MIA) involving post-mortem imaging and organ tissue sampling compared with conventional autopsy, and to compare the acceptability of percutaneous versus laparoscopic-guided biopsy.
Methods: Following termination of pregnancy(TOP) parents were offered the option of traditional autopsy and subsequently interviewed about their acceptance of MIA. The McNemar test for paired samples was used to assess the difference in acceptance of MIA and conventional autopsy. The Wilcoxon signed-rank test for paired samples was used to compare the acceptance score for percutaneous versus laparoscopic-guided biopsy. Logistic regression was selected to study the association of parental acceptance of conventional autopsy and MIA with different variables.
Results: Conventional autopsy was accepted by 42(60.0%) of the 70 parents. Regression analysis showed that non-Muslim faith was the only factor significantly associated with acceptance of conventional autopsy(p=0.030). Of 28 parents who initially refused conventional autopsy, 13(46.4%) subsequently accepted MIA, increasing acceptance to 78.6%(p
