The New England Journal of Medicine Downloaded from nejm.org at UC SHARED JOURNAL COLLECTION on February 3, 2015. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at UC SHARED JOURNAL COLLECTION on February 3, 2015. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at UC SHARED JOURNAL COLLECTION on February 3, 2015. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at UC SHARED JOURNAL COLLECTION on February 3, 2015. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at UC SHARED JOURNAL COLLECTION on February 3, 2015. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved.

The New England Journal of Medicine Downloaded from nejm.org at UC SHARED JOURNAL COLLECTION on February 3, 2015. For personal use only. No other uses without permission. Copyright © 1991 Massachusetts Medical Society. All rights reserved.

Paroxysmal nocturnal hemoglobinuria with onset in childhood and adolescence.

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematologic disorder characterized by hemoglobinuria, thrombosis, infection, and a ten...
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