Author's Accepted Manuscript Percutaneous Nephrolithotomy (PCNL) Versus Retrograde Intra-renal Surgery (RIRS) in Treatment of Large Renal Stones (>2cm) In Pediatric Patients: A Randomized Controlled Trial Karim S.M. Saad , Mohamed Elsaid Youssif , Seif Al Islam Nafis Hamdy , Ahmed Fahmy , Ahmed Gamal El Din Hanno , Ahmed R. EL-Nahas PII: DOI: Reference:

S0022-5347(15)04328-1 10.1016/j.juro.2015.06.101 JURO 12751

To appear in: The Journal of Urology Accepted Date: 2 June 2015 Please cite this article as: Saad KSM, Youssif ME, Hamdy SAIN, Fahmy A, Hanno AGED, EL-Nahas AR, Percutaneous Nephrolithotomy (PCNL) Versus Retrograde Intra-renal Surgery (RIRS) in Treatment of Large Renal Stones (>2cm) In Pediatric Patients: A Randomized Controlled Trial, The Journal of Urology® (2015), doi: 10.1016/j.juro.2015.06.101. DISCLAIMER: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our subscribers we are providing this early version of the article. The paper will be copy edited and typeset, and proof will be reviewed before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to The Journal pertain.

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ACCEPTED MANUSCRIPT

Percutaneous Nephrolithotomy (PCNL) Versus Retrograde Intra-renal Surgery (RIRS) in Treatment of Large Renal Stones (>2cm) In Pediatric Patients: A Randomized Controlled Trial 1

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Karim S.M. Saad , Mohamed Elsaid Youssif , Seif Al Islam Nafis 1

R. EL-Nahas

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From

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Urology Department, Alexandria Faculty of Medicine

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Hamdy , Ahmed Fahmy , Ahmed Gamal El Din Hanno , and Ahmed

Urology Department, Urology and Nephrology Center, Mansoura University

Keywords: Percutaneous Neprolithotomy; Retrograde intrarenal surgery;

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Flexible ureteroscopy; Renal calculi; Stones; Pediatric; Children Word Count: 2027 (Introduction through conclusion) Corresponding author:

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Karim S.M. Saad

Lecturer of Urology

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Urology Department

Faculty of Medicine, Alexandria University Address: 25 Victor Emanuel square, Smouha, Alexandria, Egypt Tel: +201227887221 Email: [email protected]

ACCEPTED MANUSCRIPT

ABSTRACT Purpose: To compare the outcomes of percutaneous nephrolithotomy (PCNL) and retrograde intrarenal surgery (RIRS) in treatment of children with >2 cm renal calculi. Patients and Methods: Between May 2011 and February 2014, 38 pediatric patients

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( 2cm were randomized between PCNL and RIRS. Demographic data, stone criteria, operative technique, radiation time, complications, blood transfusion, hemoglobin drop, stone free rates and hospital stay were compared between both groups. Stone free was document if there were no residual stones after

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one month.

Results: The study included 43 renal units; 21 units in RIRS group and 22 units in

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PCNL group. Operative time was comparable for both groups. The mean radiation time and hospital stay were longer after PCNL (P2 cm renal calculi.

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PATIENTS AND METHODS The study protocol was approved by the local ethical committee and it was conducted between May 2011 and February 2014 in urology department, Alexandria university hospital. Inclusion criteria were pediatric patients (