TRANSACTIONS OFTHEROYAI.SOCIETY OFTROPICAL M~:DICINE ANT> H~nleu~(1990) 84, 389-393
Pharmacokinetics schistosomiasis
of praziquantel
in healthy volunteers
and patients
389
with
Mohammed El M. Mandour’, Hamid El Turabi’, Mamoun M .A. Homeida’, Taha el Sadig’, Hassan M. ‘Department of Medicine, Ali*, James L. BennetP, William J. Leahey and Dean W. G. Hanon Universip of Khartoum, Khartoum, Sudan; ‘Department of Pharmacology, University of Khartoum, Khartoum, Sudan; Department of PharmacologylToxicology, Michigan State University, East Lansing, Michigan, USA; 4Department of Therapeutics and Pharmacology, UK
The Queen’s University of Belfast, Belfast, Northern Ireland,
Abstract The pharmacokinetics of a novel praziquantel preparation (Distocidem) were investigated in Sudanesepatients with hepatosplenic schistosomiasis and in healthy volunteers, and comparedwith those of BiltricidC. The results of the first study indicated greater (P
Pharmacokinetics schistosomiasis
of praziquantel
in healthy volunteers
and patients
389
with
Mohammed El M. Mandour’, Hamid El Turabi’, Mamoun M .A. Homeida’, Taha el Sadig’, Hassan M. ‘Department of Medicine, Ali*, James L. BennetP, William J. Leahey and Dean W. G. Hanon Universip of Khartoum, Khartoum, Sudan; ‘Department of Pharmacology, University of Khartoum, Khartoum, Sudan; Department of PharmacologylToxicology, Michigan State University, East Lansing, Michigan, USA; 4Department of Therapeutics and Pharmacology, UK
The Queen’s University of Belfast, Belfast, Northern Ireland,
Abstract The pharmacokinetics of a novel praziquantel preparation (Distocidem) were investigated in Sudanesepatients with hepatosplenic schistosomiasis and in healthy volunteers, and comparedwith those of BiltricidC. The results of the first study indicated greater (P
