Hemodialysis International 2015; 19:352
Letter to the Editor
Phosphate binders and metabolic acidosis
To the Editor: I read the research by Sanai et al. recently published on this journal.1 The authors compared the effects of several phosphate binders on metabolic acidosis in 12 chronic hemodialysis patients. Among these, eight patients were switched from sevelamer hydrochloride to bixalomer and subsequently re-evaluated. In my opinion, throughout this research, there are no findings allowing the authors to conclude that “chronic metabolic acidosis and ESRD were induced by HCl containing phosphate binders.” They only demonstrated that switching has improved metabolic acidosis. Moreover in my opinion, it is too hard to define
bixalomer as “ideal phosphate binder” relying on too few patients, also because they persistently show too high phosphate values.
CONFLICT OF INTEREST The author declares no conflict of interest. Marco MARANO Hemodialysis Unit, Maria Rosaria Clinic, Pompeii, Italy
REFERENCE Correspondence to: M. Marano, MD, Hemodialysis Unit, Maria Rosaria Clinic, Via Colle San Bartolomeo, 50, 80045 Pompeii, Italy. E-mail: [email protected]
1 Sanai T, Tada H, Ono T, Fukumitsu T. Phosphate binders and metabolic acidosis in patients undergoing maintenance hemodialysis—sevelamer hydrochloride, calcium carbonate, and bixalomer. Hemodial Int. 2015; 19:54–59.
© 2015 International Society for Hemodialysis DOI:10.1111/hdi.12284
352
Copyright of Hemodialysis International is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
Letter to the Editor
Phosphate binders and metabolic acidosis
To the Editor: I read the research by Sanai et al. recently published on this journal.1 The authors compared the effects of several phosphate binders on metabolic acidosis in 12 chronic hemodialysis patients. Among these, eight patients were switched from sevelamer hydrochloride to bixalomer and subsequently re-evaluated. In my opinion, throughout this research, there are no findings allowing the authors to conclude that “chronic metabolic acidosis and ESRD were induced by HCl containing phosphate binders.” They only demonstrated that switching has improved metabolic acidosis. Moreover in my opinion, it is too hard to define
bixalomer as “ideal phosphate binder” relying on too few patients, also because they persistently show too high phosphate values.
CONFLICT OF INTEREST The author declares no conflict of interest. Marco MARANO Hemodialysis Unit, Maria Rosaria Clinic, Pompeii, Italy
REFERENCE Correspondence to: M. Marano, MD, Hemodialysis Unit, Maria Rosaria Clinic, Via Colle San Bartolomeo, 50, 80045 Pompeii, Italy. E-mail: [email protected]
1 Sanai T, Tada H, Ono T, Fukumitsu T. Phosphate binders and metabolic acidosis in patients undergoing maintenance hemodialysis—sevelamer hydrochloride, calcium carbonate, and bixalomer. Hemodial Int. 2015; 19:54–59.
© 2015 International Society for Hemodialysis DOI:10.1111/hdi.12284
352
Copyright of Hemodialysis International is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
