HHS Public Access Author manuscript Author Manuscript
CNS Oncol. Author manuscript; available in PMC 2016 February 11. Published in final edited form as: CNS Oncol. 2015 December ; 4(6): 411–429. doi:10.2217/cns.15.21.
Pituitary adenomas: historical perspective, surgical management and future directions Debebe Theodros1, Mira Patel1, Jacob Ruzevick1, Michael Lim1, and Chetan Bettegowda*,1 Johns Hopkins University School of Medicine, The Johns Hopkins University Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, MD, USA
1The
Author Manuscript
Abstract
Author Manuscript
Keywords
Pituitary adenomas are among the most common central nervous system tumors. They represent a diverse group of neoplasms that may or may not secrete hormones based on their cell of origin. Epidemiologic studies have documented the incidence of pituitary adenomas within the general population to be as high as 16.7%. A growing body of work has helped to elucidate the pathogenesis of these tumors. Each subtype has been shown to demonstrate unique cellular changes potentially leading to tumorigenesis. Surgical advancements over several decades have included microsurgery and the employment of the endoscope for surgical resection. These advancements increase the likelihood of gross-total resection and have resulted in decreased patient morbidity.
microsurgery; pituitary adenomas; transsphenoidal surgery
Author Manuscript
Pituitary adenomas are a group of diverse neoplasms that typically arise from the hormonesecreting epithelial cells in the adenohypophysis of the pituitary gland and rarely metastasize [1–4]. Pituitary adenomas were classically categorized by their size and can vary dramatically with regards to their proliferative rate. Microadenomas are defined to be neoplasms
CNS Oncol. Author manuscript; available in PMC 2016 February 11. Published in final edited form as: CNS Oncol. 2015 December ; 4(6): 411–429. doi:10.2217/cns.15.21.
Pituitary adenomas: historical perspective, surgical management and future directions Debebe Theodros1, Mira Patel1, Jacob Ruzevick1, Michael Lim1, and Chetan Bettegowda*,1 Johns Hopkins University School of Medicine, The Johns Hopkins University Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, MD, USA
1The
Author Manuscript
Abstract
Author Manuscript
Keywords
Pituitary adenomas are among the most common central nervous system tumors. They represent a diverse group of neoplasms that may or may not secrete hormones based on their cell of origin. Epidemiologic studies have documented the incidence of pituitary adenomas within the general population to be as high as 16.7%. A growing body of work has helped to elucidate the pathogenesis of these tumors. Each subtype has been shown to demonstrate unique cellular changes potentially leading to tumorigenesis. Surgical advancements over several decades have included microsurgery and the employment of the endoscope for surgical resection. These advancements increase the likelihood of gross-total resection and have resulted in decreased patient morbidity.
microsurgery; pituitary adenomas; transsphenoidal surgery
Author Manuscript
Pituitary adenomas are a group of diverse neoplasms that typically arise from the hormonesecreting epithelial cells in the adenohypophysis of the pituitary gland and rarely metastasize [1–4]. Pituitary adenomas were classically categorized by their size and can vary dramatically with regards to their proliferative rate. Microadenomas are defined to be neoplasms
