Journal of Veterinary Cardiology (2014)
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www.elsevier.com/locate/jvc
Plasma and platelet serotonin concentrations in healthy dogs and dogs with myxomatous mitral valve disease Tanawan Mangklabruks, DVM, MS, Sirilak Disatian Surachetpong, DVM, MS, PhD* Chulalongkorn University, Veterinary Medicine, Faculty of Veterinary Science, Henry Dunant, Wangmai, Pathumwon, Bangkok 10330, Thailand Received 26 December 2013; received in revised form 22 May 2014; accepted 28 May 2014
KEYWORDS Canine; Circulation; Degenerative mitral valve disease; Heart; Pathogenesis
Abstract Objectives: Serotonin has been implicated in canine myxomatous mitral valve disease (MMVD); however, the sources of serotonin have not been fully elucidated. This study compared the concentration of serotonin in plasma and platelets of normal healthy small breed dogs with predisposition to MMVD and dogs with naturally occurring MMVD. Animals: 43 small-breed client-owned dogs with an approximate weight of
-, -e-
www.elsevier.com/locate/jvc
Plasma and platelet serotonin concentrations in healthy dogs and dogs with myxomatous mitral valve disease Tanawan Mangklabruks, DVM, MS, Sirilak Disatian Surachetpong, DVM, MS, PhD* Chulalongkorn University, Veterinary Medicine, Faculty of Veterinary Science, Henry Dunant, Wangmai, Pathumwon, Bangkok 10330, Thailand Received 26 December 2013; received in revised form 22 May 2014; accepted 28 May 2014
KEYWORDS Canine; Circulation; Degenerative mitral valve disease; Heart; Pathogenesis
Abstract Objectives: Serotonin has been implicated in canine myxomatous mitral valve disease (MMVD); however, the sources of serotonin have not been fully elucidated. This study compared the concentration of serotonin in plasma and platelets of normal healthy small breed dogs with predisposition to MMVD and dogs with naturally occurring MMVD. Animals: 43 small-breed client-owned dogs with an approximate weight of
