Research Briefings Neonatology 2014;106:102–106 DOI: 10.1159/000358481
Received: December 17, 2013 Accepted: December 17, 2013 Published online: May 15, 2014
Platelets for Neonatal Transfusion – Study 2: A Randomised Controlled Trial to Compare Two Different Platelet Count Thresholds for Prophylactic Platelet Transfusion to Preterm Neonates Anna Curley a Vidheya Venkatesh a Simon Stanworth c Paul Clarke d Timothy Watts e Helen New f Karen Willoughby a Rizwan Khan a Priya Muthukumar d Alison Deary b a
Cambridge University Hospitals NHS Trust, and b NHSBT Cambridge, Cambridge, c Oxford University Hospitals NHS Trust, Oxford, d Norfolk and Norwich University Hospitals NHS Trust, Norwich, e Guys and St Thomas NHS Trust, and f Imperial College Healthcare Trust, London, UK
Abstract Introduction: Neonatal thrombocytopenia is a common and important clinical problem in preterm neonates. A trial assessing clinically relevant outcomes in relation to the different platelet count thresholds used to trigger transfusion has never been undertaken in preterm neonates with severe thrombocytopenia. Objectives: Platelets for Neonatal Transfusion – Study 2 (PlaNeT-2) aims to assess whether a higher prophylactic platelet transfusion threshold is superior to the lower thresholds in current standard practice in reducing the proportion of patients who have a major bleed or die up to study day 28. Methods: PlaNeT-2 is a two-stage, randomised, parallel-group, superiority trial. PlaNet-2 compares clinical outcomes in preterm neonates (
Received: December 17, 2013 Accepted: December 17, 2013 Published online: May 15, 2014
Platelets for Neonatal Transfusion – Study 2: A Randomised Controlled Trial to Compare Two Different Platelet Count Thresholds for Prophylactic Platelet Transfusion to Preterm Neonates Anna Curley a Vidheya Venkatesh a Simon Stanworth c Paul Clarke d Timothy Watts e Helen New f Karen Willoughby a Rizwan Khan a Priya Muthukumar d Alison Deary b a
Cambridge University Hospitals NHS Trust, and b NHSBT Cambridge, Cambridge, c Oxford University Hospitals NHS Trust, Oxford, d Norfolk and Norwich University Hospitals NHS Trust, Norwich, e Guys and St Thomas NHS Trust, and f Imperial College Healthcare Trust, London, UK
Abstract Introduction: Neonatal thrombocytopenia is a common and important clinical problem in preterm neonates. A trial assessing clinically relevant outcomes in relation to the different platelet count thresholds used to trigger transfusion has never been undertaken in preterm neonates with severe thrombocytopenia. Objectives: Platelets for Neonatal Transfusion – Study 2 (PlaNeT-2) aims to assess whether a higher prophylactic platelet transfusion threshold is superior to the lower thresholds in current standard practice in reducing the proportion of patients who have a major bleed or die up to study day 28. Methods: PlaNeT-2 is a two-stage, randomised, parallel-group, superiority trial. PlaNet-2 compares clinical outcomes in preterm neonates (
