BJA
Correspondence
3 The National Joint Registry. Available from http://www.njrcentre.org .uk/njrcentre/Default.aspx 4 Franklin J, Ingvarsson T, Englund M, Lohmander LS. Sex differences in the association between BMI and total hip or total knee joint replacement resulting from osteoarthritis. Ann Rheum Dis 2009; 68: 536– 40 5 Memtsoudis SG, Sun X, Chiu Y,et al. Perioperative comparative effectiveness of anesthetic technique in orthopedic patients. Anaesthesiology 2013; 118: 1046–58
1 Harsten A, Kehlet H, Toksvig-Larsen S. Recovery after total intravenous general anesthesia or spinal anaesthesia for total knee arthroplasty. Br J Anaesth 2013; 111: 391– 9 2 McCarteny CJL, Choi S. Does anaesthetic technique really matter for total knee arthroplasty? Br J Anaesth 2013; 111: 331–3 3 Joshi G, Ogunnaike B. Consequences of inadequate postoperative pain relief and chronic persistent postoperative pain. Anesthesiol Clin North America 2005; 23: 21– 36
doi:10.1093/bja/aeu071 doi:10.1093/bja/aeu072
Poor pain control rather than anaesthetic technique influences outcome in total knee arthroplasty
Declaration of interest None declared. M. Chincholkar Salford, UK E-mail: [email protected]
764
Reply from the authors to Dr Reed Editor—We thank Dr Reed for his letter on our clinical investigation.1 2 We agree that the administration of i.v. oxycodone to our target-controlled infusion (TCI) anaesthesia group could have influenced the postoperative pain scores. However, administering i.v. opioids towards the end of a TCIanaesthetic is almost to be considered as the modus operandi for TCI anaesthesia due to the fact that remifentanil has a very short-lasting analgesic effect. Hence, this could almost be considered as a part of the TCI technique. Whether patients with a BMI of 35 or more should have been excluded or not in this study is an interesting and relevant question. By excluding patients with a BMI exceeding 35, one might argue that our sample population does not perfectly reflect the general population undergoing total knee replacement. It is true that our study was written before the publication of the study by Memtsoudis and colleagues.3 However, as pointed out by an editorial4 in the same issue of Anesthesiology, the trial by Memtsoudis and colleagues is observational rather than experimental in nature. As such, treatment assignment was non-random, creating the real possibility that the authors’ findings may reflect the confounding effects of differences in patient severity rather than effects attributed to anaesthesia type per se.
Declaration of interest None declared. A. Harsten Hasssleholm, Sweden E-mail: [email protected] 1 Harsten A, Kehlet H, Toksvig-Larsen S. Recovery after total intravenous general anesthesia or spinal anaesthesia for total knee arthroplasty. Br J Anaesth 2013; 111: 391– 9 2 McCarteny CJL, Choi S. Does anaesthetic technique really matter for total knee arthroplasty? Br J Anaesth 2013; 111: 331–3 3 Memtsoudis SG, Sun X, Chiu Y, et al. Perioperative comparative effectiveness of anesthetic technique in orthopedic patients. Anaesthesiology 2013; 118: 1046–58
Downloaded from http://bja.oxfordjournals.org/ by guest on August 13, 2015
Editor—The study by Harsten and colleagues1 2 demonstrated that patients having spinal anaesthesia (SA) had worse pain control at 6 h, more opioid consumption, more nausea, vomiting, and dizziness when compared with those having general anaesthesia (GA). All of these findings could be explained by the lack of appropriate pain relief as the spinal anaesthetic wore off. The patients having a GA were given oxycodone intraoperatively, whereas those having SA did not have any i.v. analgesia. The SA group were unsurprisingly in severe pain at 6 h and were probably playing catch up with analgesia for a considerable period of time. This explains the higher number of patient-controlled analgesia doses requested but not administered in the SA group. The poor pain control in the spinal anaesthetic group may have led to patients overcompensating and consuming more opioids when compared with the GA group. Poor pain control and higher opioid use may explain the higher incidence of postoperative nausea and vomiting in the SA group. Inadequate postoperative pain relief results in delayed recovery and poor patient satisfaction.3 This is perhaps why most patients who had SA preferred to have GA in the future. The length of stay (LOS) was shorter in the GA group (46 h) when compared with the SA group (52 h). This is clearly not clinically significant. The statistics used for calculating the sample size is not very clear and one can only assume that the sample size was calculated on the assumption that the difference in the LOS between the two groups was 24 h. This assumption has led to the underestimation of the sample size required. A number of other outcomes have been studied and corrections have not been made for multiple testing. Nausea, vomiting, and dizziness were assessed at fixed times on days 1 and 2 as opposed to fixed time periods after the end of surgery. There are a number of methodological flaws in this study that make the validity of this study questionable.
Anaesthesia for elective total knee arthroplasty
Correspondence
3 The National Joint Registry. Available from http://www.njrcentre.org .uk/njrcentre/Default.aspx 4 Franklin J, Ingvarsson T, Englund M, Lohmander LS. Sex differences in the association between BMI and total hip or total knee joint replacement resulting from osteoarthritis. Ann Rheum Dis 2009; 68: 536– 40 5 Memtsoudis SG, Sun X, Chiu Y,et al. Perioperative comparative effectiveness of anesthetic technique in orthopedic patients. Anaesthesiology 2013; 118: 1046–58
1 Harsten A, Kehlet H, Toksvig-Larsen S. Recovery after total intravenous general anesthesia or spinal anaesthesia for total knee arthroplasty. Br J Anaesth 2013; 111: 391– 9 2 McCarteny CJL, Choi S. Does anaesthetic technique really matter for total knee arthroplasty? Br J Anaesth 2013; 111: 331–3 3 Joshi G, Ogunnaike B. Consequences of inadequate postoperative pain relief and chronic persistent postoperative pain. Anesthesiol Clin North America 2005; 23: 21– 36
doi:10.1093/bja/aeu071 doi:10.1093/bja/aeu072
Poor pain control rather than anaesthetic technique influences outcome in total knee arthroplasty
Declaration of interest None declared. M. Chincholkar Salford, UK E-mail: [email protected]
764
Reply from the authors to Dr Reed Editor—We thank Dr Reed for his letter on our clinical investigation.1 2 We agree that the administration of i.v. oxycodone to our target-controlled infusion (TCI) anaesthesia group could have influenced the postoperative pain scores. However, administering i.v. opioids towards the end of a TCIanaesthetic is almost to be considered as the modus operandi for TCI anaesthesia due to the fact that remifentanil has a very short-lasting analgesic effect. Hence, this could almost be considered as a part of the TCI technique. Whether patients with a BMI of 35 or more should have been excluded or not in this study is an interesting and relevant question. By excluding patients with a BMI exceeding 35, one might argue that our sample population does not perfectly reflect the general population undergoing total knee replacement. It is true that our study was written before the publication of the study by Memtsoudis and colleagues.3 However, as pointed out by an editorial4 in the same issue of Anesthesiology, the trial by Memtsoudis and colleagues is observational rather than experimental in nature. As such, treatment assignment was non-random, creating the real possibility that the authors’ findings may reflect the confounding effects of differences in patient severity rather than effects attributed to anaesthesia type per se.
Declaration of interest None declared. A. Harsten Hasssleholm, Sweden E-mail: [email protected] 1 Harsten A, Kehlet H, Toksvig-Larsen S. Recovery after total intravenous general anesthesia or spinal anaesthesia for total knee arthroplasty. Br J Anaesth 2013; 111: 391– 9 2 McCarteny CJL, Choi S. Does anaesthetic technique really matter for total knee arthroplasty? Br J Anaesth 2013; 111: 331–3 3 Memtsoudis SG, Sun X, Chiu Y, et al. Perioperative comparative effectiveness of anesthetic technique in orthopedic patients. Anaesthesiology 2013; 118: 1046–58
Downloaded from http://bja.oxfordjournals.org/ by guest on August 13, 2015
Editor—The study by Harsten and colleagues1 2 demonstrated that patients having spinal anaesthesia (SA) had worse pain control at 6 h, more opioid consumption, more nausea, vomiting, and dizziness when compared with those having general anaesthesia (GA). All of these findings could be explained by the lack of appropriate pain relief as the spinal anaesthetic wore off. The patients having a GA were given oxycodone intraoperatively, whereas those having SA did not have any i.v. analgesia. The SA group were unsurprisingly in severe pain at 6 h and were probably playing catch up with analgesia for a considerable period of time. This explains the higher number of patient-controlled analgesia doses requested but not administered in the SA group. The poor pain control in the spinal anaesthetic group may have led to patients overcompensating and consuming more opioids when compared with the GA group. Poor pain control and higher opioid use may explain the higher incidence of postoperative nausea and vomiting in the SA group. Inadequate postoperative pain relief results in delayed recovery and poor patient satisfaction.3 This is perhaps why most patients who had SA preferred to have GA in the future. The length of stay (LOS) was shorter in the GA group (46 h) when compared with the SA group (52 h). This is clearly not clinically significant. The statistics used for calculating the sample size is not very clear and one can only assume that the sample size was calculated on the assumption that the difference in the LOS between the two groups was 24 h. This assumption has led to the underestimation of the sample size required. A number of other outcomes have been studied and corrections have not been made for multiple testing. Nausea, vomiting, and dizziness were assessed at fixed times on days 1 and 2 as opposed to fixed time periods after the end of surgery. There are a number of methodological flaws in this study that make the validity of this study questionable.
Anaesthesia for elective total knee arthroplasty
