Eq). Eye Res. (1979) 29, 323-326 LETTER

TO THE

EDITORS

Possible Single-gene Control of Presence or Absence of a Lens Protein in the Mouse An earlier survey of crystallin lens proteins from rt~l~resentativcsof 11 inbred mouse strains: A/Jax. balb/c, C3H, ST/bJ, C57BL/6 ant1 (‘57BL/10: DBA/2, ZRDCVS, SEC!/Re. C’orclovan.Y/He, and YBR/a, using slab 1~olyacrylamiclegel electrophoresis in ;I tliscontim~ous buffer sydeln (Grieffendorf. 1969). rrvealctl the presence of a band in the T/He and YBR/ it which was a,lJstnt front the other r&e &aim (Fig. 1). The prrswt It \vils t,he fast,est-migrating of the 14 bands rwolrallle in tlmt systrm. stucl\- investiga,tes this fast rnigrnting protein lmltl.

Frc:. 1. Electropherogram of crystallin lens proteins from sinple individuals of eleven mouse strains. The tlwignations (‘10 and B6 are two different sublines of the (57 Black strain. Origin is at the cathode i--j. The most anotlal (f) hand, present only in YBR/a (indicat.ed by arrow) and Y/He skains is the pwtcin of inkrest in the present. report. Photograph is from (kieffentlorf (1969).

This hand seemslikely to be a gamma crystallin, and our data suggeststhat t,he difference in its presenceor absencecould very well he determined hy a single gene. Our wwrch of the literature did not, reveal any rclports of lmecling experiments involving illentlelizing intraspecific variations in lens proteins in n~anmials, and onl? tine incomplete study in fish. Several reports of intraspecific variation in fish species md in nlaiinnsls suggest possible polygcnically controlled variat,ions and do not involve breeding experiments. A study by Eckroat and Wright (1969). while suggesting singIt>genediffwences in Brook Trout,. is flawed by not knowning parental phenotypes. nor going beyond a first generation outcross. Xoser and Gleucksohn-Wa,elsch (1967) 0014-

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Possible single-gene control of presence or absence of a lens protein in the mouse.

Eq). Eye Res. (1979) 29, 323-326 LETTER TO THE EDITORS Possible Single-gene Control of Presence or Absence of a Lens Protein in the Mouse An earlie...
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