DEVELOPMENTAL MEDICINE & CHILD NEUROLOGY
ORIGINAL ARTICLE
Post-stroke epilepsy in Polish paediatric patients ILONA KOPYTA 1
| BEATA SARECKA-HUJAR 2 | MICHAL SKRZYPEK 3
1 Department of Paediatrics and Developmental Age Neurology, School of Medicine in Katowice, Medical University of Silesia, Katowice; 2 Department of Drug Form Technology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice; 3 Department of Biostatistics, School of Public Health in Bytom, Medical University of Silesia, Katowice, Poland. Correspondence to Beata Sarecka-Hujar at Department of Drug Form Technology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Kasztanowa Str 3, 41–200 Sosnowiec, Poland. E-mail: [email protected]
PUBLICATION DATA
Accepted for publication 6th January 2015. Published online 18th February 2015. ABBREVIATIONS
AIS FCA LACI PACI POCI TACI
Arterial ischaemic stroke Focal cerebral arteriopathy Lacunar anterior circulation infarct Partial anterior circulation infarct Posterior circulation infarct Total anterior circulation infarct
AIM The aim of this study was to characterize a group of children with early and late remote seizures, which occurred after arterial ischaemic stroke (AIS), and to find predictors of poststroke seizures. METHOD The study group, recruited in the Department of Neuropediatrics (Medical University of Silesia, Katowice, Poland), comprised 78 individuals (range 1–18y) who had suffered a stroke: 13 participants had early seizures, occurring up to 7 days after AIS, seven participants had late remote seizures, occurring more than 7 days after AIS, and 58 participants had no seizures. RESULTS Post-stroke epilepsy occurred in 10 patients having post-stroke seizures. Participants affected by late remote seizures were younger, on average, than participants unaffected by seizures. The frequencies of total anterior circulation infarct (TACI) stroke subtype and focal cerebral arteriopathy (FCA) were significantly higher in the late seizure subgroup than in the subgroup without seizures (71% vs 26%, p=0.014, OR 7.17, and 100% vs 51%, p=0.015 respectively). Multivariable Cox analysis showed that age at time of stroke (p=0.027), FCA (p=0.010), and the number of infarct foci (p
ORIGINAL ARTICLE
Post-stroke epilepsy in Polish paediatric patients ILONA KOPYTA 1
| BEATA SARECKA-HUJAR 2 | MICHAL SKRZYPEK 3
1 Department of Paediatrics and Developmental Age Neurology, School of Medicine in Katowice, Medical University of Silesia, Katowice; 2 Department of Drug Form Technology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice; 3 Department of Biostatistics, School of Public Health in Bytom, Medical University of Silesia, Katowice, Poland. Correspondence to Beata Sarecka-Hujar at Department of Drug Form Technology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Kasztanowa Str 3, 41–200 Sosnowiec, Poland. E-mail: [email protected]
PUBLICATION DATA
Accepted for publication 6th January 2015. Published online 18th February 2015. ABBREVIATIONS
AIS FCA LACI PACI POCI TACI
Arterial ischaemic stroke Focal cerebral arteriopathy Lacunar anterior circulation infarct Partial anterior circulation infarct Posterior circulation infarct Total anterior circulation infarct
AIM The aim of this study was to characterize a group of children with early and late remote seizures, which occurred after arterial ischaemic stroke (AIS), and to find predictors of poststroke seizures. METHOD The study group, recruited in the Department of Neuropediatrics (Medical University of Silesia, Katowice, Poland), comprised 78 individuals (range 1–18y) who had suffered a stroke: 13 participants had early seizures, occurring up to 7 days after AIS, seven participants had late remote seizures, occurring more than 7 days after AIS, and 58 participants had no seizures. RESULTS Post-stroke epilepsy occurred in 10 patients having post-stroke seizures. Participants affected by late remote seizures were younger, on average, than participants unaffected by seizures. The frequencies of total anterior circulation infarct (TACI) stroke subtype and focal cerebral arteriopathy (FCA) were significantly higher in the late seizure subgroup than in the subgroup without seizures (71% vs 26%, p=0.014, OR 7.17, and 100% vs 51%, p=0.015 respectively). Multivariable Cox analysis showed that age at time of stroke (p=0.027), FCA (p=0.010), and the number of infarct foci (p
