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JAMA Pediatr. Author manuscript; available in PMC 2016 December 07. Published in final edited form as: JAMA Pediatr. 2015 December 7; 169(12): e153785. doi:10.1001/jamapediatrics.2015.3785.
Postnatal Cytomegalovirus Infection and the Risk of Bronchopulmonary Dysplasia
Author Manuscript
Matthew S. Kelly, MD, MPH, Daniel K. Benjamin, PhD, Karen M. Puopolo, MD, MPH, Matthew M. Laughon, MD, MPH, Reese H. Clark, MD, Sagori Mukhopadhyay, MD, MMSc, Daniel K. Benjamin Jr., MD, PhD, P. Brian Smith, MD, MPH, MHS, and Sallie R. Permar, MD, PhD Duke Clinical Research Institute (Drs. Kelly, Benjamin Jr., and Smith), Duke University School of Medicine, Durham, NC; Division of Pediatric Infectious Diseases (Drs. Kelly, Benjamin Jr., Smith, and Permar), Duke University School of Medicine, Durham, NC; Department of Economics (Dr. Benjamin), Clemson University, Clemson, SC; Division of Neonatology (Drs. Puopolo and Mukhopadhyay), Children’s Hospital of Philadelphia, Philadelphia, PA; Division of NeonatalPerinatal Medicine (Dr. Laughon), The University of North Carolina at Chapel Hill, Chapel Hill, NC; Pediatrix-Obstetrix Center for Research and Education (Dr. Clark), Sunrise, FL
Abstract
Author Manuscript
Importance—Postnatally acquired cytomegalovirus (CMV) is typically benign in term infants but, in very low birth weight (VLBW) infants, can cause pneumonitis and sepsis-like illness. Whether postnatal CMV infection results in long-term pulmonary sequelae in these infants is unknown. Objective—To investigate the relationship between postnatal CMV infection and bronchopulmonary dysplasia (BPD) and mortality in a large, multicenter cohort of VLBW infants. Design—Propensity-matched retrospective cohort study. Setting—348 neonatal intensive care units in the United States from 1997–2012. Participants—Hospitalized VLBW (90 U/L. For the purposes of this analysis, only postnatal CMV infections occurring at
JAMA Pediatr. Author manuscript; available in PMC 2016 December 07. Published in final edited form as: JAMA Pediatr. 2015 December 7; 169(12): e153785. doi:10.1001/jamapediatrics.2015.3785.
Postnatal Cytomegalovirus Infection and the Risk of Bronchopulmonary Dysplasia
Author Manuscript
Matthew S. Kelly, MD, MPH, Daniel K. Benjamin, PhD, Karen M. Puopolo, MD, MPH, Matthew M. Laughon, MD, MPH, Reese H. Clark, MD, Sagori Mukhopadhyay, MD, MMSc, Daniel K. Benjamin Jr., MD, PhD, P. Brian Smith, MD, MPH, MHS, and Sallie R. Permar, MD, PhD Duke Clinical Research Institute (Drs. Kelly, Benjamin Jr., and Smith), Duke University School of Medicine, Durham, NC; Division of Pediatric Infectious Diseases (Drs. Kelly, Benjamin Jr., Smith, and Permar), Duke University School of Medicine, Durham, NC; Department of Economics (Dr. Benjamin), Clemson University, Clemson, SC; Division of Neonatology (Drs. Puopolo and Mukhopadhyay), Children’s Hospital of Philadelphia, Philadelphia, PA; Division of NeonatalPerinatal Medicine (Dr. Laughon), The University of North Carolina at Chapel Hill, Chapel Hill, NC; Pediatrix-Obstetrix Center for Research and Education (Dr. Clark), Sunrise, FL
Abstract
Author Manuscript
Importance—Postnatally acquired cytomegalovirus (CMV) is typically benign in term infants but, in very low birth weight (VLBW) infants, can cause pneumonitis and sepsis-like illness. Whether postnatal CMV infection results in long-term pulmonary sequelae in these infants is unknown. Objective—To investigate the relationship between postnatal CMV infection and bronchopulmonary dysplasia (BPD) and mortality in a large, multicenter cohort of VLBW infants. Design—Propensity-matched retrospective cohort study. Setting—348 neonatal intensive care units in the United States from 1997–2012. Participants—Hospitalized VLBW (90 U/L. For the purposes of this analysis, only postnatal CMV infections occurring at
