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Rejuvenation Research Potential inhibitory effects of L-carnitine supplementation on tissue advanced glycation end products in patients with hemodialysis (doi: 10.1089/rej.2013.1459) This article has been peer-reviewed and accepted for publication, but has yet to undergo copyediting and proof correction. The final published version may differ from this proof.
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Potential inhibitory effects of L-carnitine supplementation on tissue advanced glycation end products in patients with hemodialysis Kei Fukami1, Sho-ichi Yamagishi2, Kazuko Sakai1, Yusuke Kaida1, Takeki Adachi1, Ryotaro Ando1 and Seiya Okuda1 1
Division of Nephrology, Department of Medicine, 2Department of Pathophysiology
and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan Word content; Abstract: 253 Main body: 2124 KEY WORDS; hemodialysis, carnitine, AGEs Running title; L-carnitine decreases tissue AGEs levels Corresponding author: Kei Fukami, MD, PhD Division of Nephrology Department of Medicine Kurume University School of Medicine 67 Asahi-machi, Kurume Fukuoka 830-0011 Japan
Abbreviations: AGEs; advanced glycation end products, CVD; cardiovascular disease, SAF; skin autofluorescence, HD; hemodialysis, LDL; low-density lipoprotein, HDL; high-density lipoprotein, PTH; parathyroid hormone, CRP; C-reactive protein, 2-MG; 2-microglobulin, ∆; delta, ALT; alanine transaminase, ESRD; end-stage renal disease
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Rejuvenation Research Potential inhibitory effects of L-carnitine supplementation on tissue advanced glycation end products in patients with hemodialysis (doi: 10.1089/rej.2013.1459) This article has been peer-reviewed and accepted for publication, but has yet to undergo copyediting and proof correction. The final published version may differ from this proof.
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Abstract Background and Aims: Advanced glycation end products (AGEs) contribute to cardiovascular disease in patients with hemodialysis. We have recently found that carnitine levels are inversely associated with skin AGE levels in hemodialysis patients. We examined whether L-carnitine supplementation reduced skin AGE levels in hemodialysis patients with carnitine deficiency. Methods: This has been a single-center study. One hundred and two hemodialysis patients (total carnitine levels
Rejuvenation Research Potential inhibitory effects of L-carnitine supplementation on tissue advanced glycation end products in patients with hemodialysis (doi: 10.1089/rej.2013.1459) This article has been peer-reviewed and accepted for publication, but has yet to undergo copyediting and proof correction. The final published version may differ from this proof.
1
Potential inhibitory effects of L-carnitine supplementation on tissue advanced glycation end products in patients with hemodialysis Kei Fukami1, Sho-ichi Yamagishi2, Kazuko Sakai1, Yusuke Kaida1, Takeki Adachi1, Ryotaro Ando1 and Seiya Okuda1 1
Division of Nephrology, Department of Medicine, 2Department of Pathophysiology
and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan Word content; Abstract: 253 Main body: 2124 KEY WORDS; hemodialysis, carnitine, AGEs Running title; L-carnitine decreases tissue AGEs levels Corresponding author: Kei Fukami, MD, PhD Division of Nephrology Department of Medicine Kurume University School of Medicine 67 Asahi-machi, Kurume Fukuoka 830-0011 Japan
Abbreviations: AGEs; advanced glycation end products, CVD; cardiovascular disease, SAF; skin autofluorescence, HD; hemodialysis, LDL; low-density lipoprotein, HDL; high-density lipoprotein, PTH; parathyroid hormone, CRP; C-reactive protein, 2-MG; 2-microglobulin, ∆; delta, ALT; alanine transaminase, ESRD; end-stage renal disease
1
Page 2 of 25
Rejuvenation Research Potential inhibitory effects of L-carnitine supplementation on tissue advanced glycation end products in patients with hemodialysis (doi: 10.1089/rej.2013.1459) This article has been peer-reviewed and accepted for publication, but has yet to undergo copyediting and proof correction. The final published version may differ from this proof.
2
Abstract Background and Aims: Advanced glycation end products (AGEs) contribute to cardiovascular disease in patients with hemodialysis. We have recently found that carnitine levels are inversely associated with skin AGE levels in hemodialysis patients. We examined whether L-carnitine supplementation reduced skin AGE levels in hemodialysis patients with carnitine deficiency. Methods: This has been a single-center study. One hundred and two hemodialysis patients (total carnitine levels
