Caries Res. 13: 203-210 (1979)
Pre- or Post-Eruptive Effects of Strontium Alone or in Combination with Fluoride on Dental Caries in the Rat C. Meyerowitz, P. C. Spector and M. E. J. Curzon Eastman Dental Center and University of Rochester, Rochester, N. Y.
Key Words. Caries • Fluoride • Rat • Strontium
A suggested association of low caries prevalence and strontium (Sr) in water sup plies by Lôdrop [1953], and later by Losee and Adkins [1969] has subsequently been substantiated by further epidemiologic stud ies [Curzon el al., 1970, 1978]. Attempts to prevent caries in experimental animals by using Sr by injection, or via the food and water, however, have been equivocal with both increases and decreases in caries being reported. Early work by Rygh [1949] indicated that Sr was necessary for proper calcifica tion of bones and teeth, as well as being as sociated with low dental caries prevalence.
Shaw and Griffiths [1961] used SrCOa at doses of between 0.1 and 2.0% of the food fed to rats, and found modest, but inconsist ent reductions in caries. Recently, Gedalia et al. [1975] produced generally significant reductions in caries prevalence in hamsters using SrCl2 pre-eruptively at levels of 25 or 75 mg Sr/1. A lack of a post-eruptive effect of Sr administration was suggested as re flecting the incorporation of Sr in enamel largely during calcification, and before tooth eruption. Gedalia’s study also showed that 25 mg Sr/1 was more effective than 75 mg Sr/1 in preventing caries. Other studies have found Sr to be asso-
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Abstract. Doses of strontium were given pre-eruptively to rats at ().(), 2.5, 5.0 and 10.0 pg Sr/lOg body weight, with or without fluoride at 1.0,»g/10g body weight by eso phageal intubation. In a second experiment strontium at concentrations of 0, 50, 100 and 150mgSr/I, with and without fluoride at 10 mg/1, were given via the drinking water post-eruptively. Caries scores were made for buccolingual, morsal, sulcal und proximal lesions in all rats. Slight reductions in buccolingual caries scores were seen in rats given 5 .0 /
Pre- or Post-Eruptive Effects of Strontium Alone or in Combination with Fluoride on Dental Caries in the Rat C. Meyerowitz, P. C. Spector and M. E. J. Curzon Eastman Dental Center and University of Rochester, Rochester, N. Y.
Key Words. Caries • Fluoride • Rat • Strontium
A suggested association of low caries prevalence and strontium (Sr) in water sup plies by Lôdrop [1953], and later by Losee and Adkins [1969] has subsequently been substantiated by further epidemiologic stud ies [Curzon el al., 1970, 1978]. Attempts to prevent caries in experimental animals by using Sr by injection, or via the food and water, however, have been equivocal with both increases and decreases in caries being reported. Early work by Rygh [1949] indicated that Sr was necessary for proper calcifica tion of bones and teeth, as well as being as sociated with low dental caries prevalence.
Shaw and Griffiths [1961] used SrCOa at doses of between 0.1 and 2.0% of the food fed to rats, and found modest, but inconsist ent reductions in caries. Recently, Gedalia et al. [1975] produced generally significant reductions in caries prevalence in hamsters using SrCl2 pre-eruptively at levels of 25 or 75 mg Sr/1. A lack of a post-eruptive effect of Sr administration was suggested as re flecting the incorporation of Sr in enamel largely during calcification, and before tooth eruption. Gedalia’s study also showed that 25 mg Sr/1 was more effective than 75 mg Sr/1 in preventing caries. Other studies have found Sr to be asso-
Downloaded by: Univ. of California Santa Barbara 128.111.121.42 - 3/5/2018 10:14:34 PM
Abstract. Doses of strontium were given pre-eruptively to rats at ().(), 2.5, 5.0 and 10.0 pg Sr/lOg body weight, with or without fluoride at 1.0,»g/10g body weight by eso phageal intubation. In a second experiment strontium at concentrations of 0, 50, 100 and 150mgSr/I, with and without fluoride at 10 mg/1, were given via the drinking water post-eruptively. Caries scores were made for buccolingual, morsal, sulcal und proximal lesions in all rats. Slight reductions in buccolingual caries scores were seen in rats given 5 .0 /
