European Journal of Heart Failure (2014) doi:10.1002/ejhf.119

Predictors of mortality in acute heart failure: interaction between diabetes and impaired left ventricular ejection fraction Yun Yun Go1*, John Carson Allen2, Shaw Yang Chia3, Ling Ling Sim3, Fazlur Rehman Jaufeerally4, Jonathan Yap1, Chi Keong Ching1, David Sim1, Bernard Kwok1, and Reginald Liew2 1 Department

of Cardiology, National Heart Centre Singapore, Singapore; 2 Duke-NUS Graduate Medical School Singapore, Singapore; 3 Singapore Cardiac Data Bank, Singapore; and 4 Department of Internal Medicine, Singapore General Hospital, Singapore

Received 30 November 2013; revised 9 March 2014; accepted 2 May 2014

Aim

The aim of this study was to test the hypothesis that diabetes modifies the risk of mortality in acute heart failure patients, especially in patients with impaired LVEF, and that impaired LVEF in turn modifies the risk of mortality in diabetic patients. ..................................................................................................................................................................... Methods We studied 2121 patients with acute heart failure admitted at two centres in Singapore from 1 January 2008 to 31 and results December 2009. The date of the last follow-up was 31 December 2011, with a median follow-up time (interquartile range) of 914 (442–1190) days. Cox regression was used to estimate hazard ratios for all-cause mortality in patients with LVEF ≥50%, LVEF 30–49%, and LVEF