Pretty in pink 1

Contributed by Carolina Escobar1 and Jennifer Neel2 Universidad Santo Tom as, Santiago, Chile and 2North Carolina State University, Raleigh, NC

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Figure 1. Canine, fine-needle aspirates, Wright–Giemsa. (A), (C), (E) 910 objective, (B), (D), (F) 950 objective. (A) and (B) Submandibular mass (carcinosarcoma of the salivary gland). (C) and (D) Laryngeal mass (chondroma). (E) and (F) Cutaneous mass on the right hip (malignant peripheral nerve sheath tumor).

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Vet Clin Pathol 42/4 (2013) 403–404 ©2013 American Society for Veterinary Clinical Pathology

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A little something on extracellular matrix Extracellular matrix (ECM) is a collection of proteins, glycoproteins, proteoglycans, and polysaccharides with different physical and biochemical properties.1 It provides a structural framework that is essential for tissue growth, remodeling and maintenance, stabilizes tissue structures and provides needed elasticity. It also allows important communication between the environment and cells.2 ECM regulates many aspects of cell behavior, including cell proliferation and growth, survival, change in cell shape, migration, and differentiation.3

References 1. Lu P, Weaver V, Werb Z. The extracellular matrix: a dynamic niche in cancer progression. J Cell Sci. 2008;196:396–406. 2. Kurtz A, Oh S. Age related changes of the extracellular matrix and stem cell maintenanace. Prev Med 2012;54 Suppl:S50–S56. 3. Daley WP, Peters SB, Larsen M. Extracellular matrix dynamics in development and regenerative medicine. J Cell Sci. 2008;121:255–264.

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Vet Clin Pathol 42/4 (2013) 403–404 ©2013 American Society for Veterinary Clinical Pathology

Pretty in pink. Canine fine needle aspirates of extracellular matrix.

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