Histopathology 2014, 65, 606–612. DOI: 10.1111/his.12451
Primordial odontogenic tumour: clinicopathological analysis of six cases of a previously undescribed entity Adalberto Mosqueda-Taylor, Fabio Ramoa Pires,1 Jose Manuel Aguirre-Urızar,2 Roman Carlos-Bregni,3 Jose Mario de la Piedra-Garza,4 Rafael Martınez-Conde,2 6 Guillermo Martınez-Mata,5 Sergio J Carre~ no-Alvarez, Henrique Martins da Silveira,7 7 Bruno Santos de Barros Dias & Oslei Paes de Almeida8 Departamento de Atencion a la Salud, Universidad Autonoma Metropolitana Xochimilco, Mexico DF, Mexico, 1Patologia Bucal, Faculdade de Odontologia, Universidade do Estado do Rio de Janeiro, Programa de Pos-graduacß~ao em Odontologia, Universidade Estacio de Sa, Rio de Janeiro, Brazil, 2Departamento de Estomatologıa II UFI 11/25, Universidad del Paıs Vasco/EHU, Bilbao, Spain, 3Centro Clınico de Cabeza y Cuello/Hospital Herrera-Llerandi, Guatemala City, Guatemala, 4Division de Estudios de Posgrado e Investigacion, Facultad de Odontologıa, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico, 5Facultad de Odontologıa, Universidad Autonoma de Chihuahua, Chihuahua, Mexico, 6Hospital Central Sur de Alta Especialidad, PEMEX, Mexico DF, Mexico, 7Cirurgia Bucomaxilofacial, Hospital Universitario Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, and 8Faculdade de Odontologia de Piracicaba, UNICAMP, Piracicaba, Brazil Date of submission 15 September 2013 Accepted for publication 30 April 2014 Published online Article Accepted 7 May 2014
Mosqueda-Taylor A, Pires F R, Aguirre-Urızar J M, Carlos-Bregni R, de la Piedra-Garza J M, Martınez-Conde R, Martınez-Mata G, Carre~ no-Alvarez S J, da Silveira H M, de Barros Dias B S & de Almeida O P (2014) Histopathology 65, 606–612
Primordial odontogenic tumour: clinicopathological analysis of six cases of a previously undescribed entity Aim: To describe the clinicopathological and immunohistochemical features of six tumours that do not fulfil the criteria of any of the currently classified odontogenic tumours. Methods and results: The patients were three males and three females, whose ages ranged from 3 years to 18 years (mean, 11.5 years). In all cases there were well-defined radiolucencies associated with unerupted teeth apparently showing a pericoronal relationship. Microscopically, all tumours were composed of variably cellular loose fibrous tissue with areas similar to dental papilla, entirely surrounded by cuboidal to columnar epithelium resembling the internal epithelium of the enamel organ. Mesenchy-
mal tissue was positive only for vimentin, and Ki67 expression was very low (
Primordial odontogenic tumour: clinicopathological analysis of six cases of a previously undescribed entity Adalberto Mosqueda-Taylor, Fabio Ramoa Pires,1 Jose Manuel Aguirre-Urızar,2 Roman Carlos-Bregni,3 Jose Mario de la Piedra-Garza,4 Rafael Martınez-Conde,2 6 Guillermo Martınez-Mata,5 Sergio J Carre~ no-Alvarez, Henrique Martins da Silveira,7 7 Bruno Santos de Barros Dias & Oslei Paes de Almeida8 Departamento de Atencion a la Salud, Universidad Autonoma Metropolitana Xochimilco, Mexico DF, Mexico, 1Patologia Bucal, Faculdade de Odontologia, Universidade do Estado do Rio de Janeiro, Programa de Pos-graduacß~ao em Odontologia, Universidade Estacio de Sa, Rio de Janeiro, Brazil, 2Departamento de Estomatologıa II UFI 11/25, Universidad del Paıs Vasco/EHU, Bilbao, Spain, 3Centro Clınico de Cabeza y Cuello/Hospital Herrera-Llerandi, Guatemala City, Guatemala, 4Division de Estudios de Posgrado e Investigacion, Facultad de Odontologıa, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico, 5Facultad de Odontologıa, Universidad Autonoma de Chihuahua, Chihuahua, Mexico, 6Hospital Central Sur de Alta Especialidad, PEMEX, Mexico DF, Mexico, 7Cirurgia Bucomaxilofacial, Hospital Universitario Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, and 8Faculdade de Odontologia de Piracicaba, UNICAMP, Piracicaba, Brazil Date of submission 15 September 2013 Accepted for publication 30 April 2014 Published online Article Accepted 7 May 2014
Mosqueda-Taylor A, Pires F R, Aguirre-Urızar J M, Carlos-Bregni R, de la Piedra-Garza J M, Martınez-Conde R, Martınez-Mata G, Carre~ no-Alvarez S J, da Silveira H M, de Barros Dias B S & de Almeida O P (2014) Histopathology 65, 606–612
Primordial odontogenic tumour: clinicopathological analysis of six cases of a previously undescribed entity Aim: To describe the clinicopathological and immunohistochemical features of six tumours that do not fulfil the criteria of any of the currently classified odontogenic tumours. Methods and results: The patients were three males and three females, whose ages ranged from 3 years to 18 years (mean, 11.5 years). In all cases there were well-defined radiolucencies associated with unerupted teeth apparently showing a pericoronal relationship. Microscopically, all tumours were composed of variably cellular loose fibrous tissue with areas similar to dental papilla, entirely surrounded by cuboidal to columnar epithelium resembling the internal epithelium of the enamel organ. Mesenchy-
mal tissue was positive only for vimentin, and Ki67 expression was very low (
