Original Article
Prognostic Factors for Outcome in Pediatric Probable Lesional Frontal Lobe Epilepsy With an Unknown Cause (Cryptogenic)
Journal of Child Neurology 2014, Vol. 29(12) 1660-1663 ª The Author(s) 2013 Reprints and permission: sagepub.com/journalsPermissions.nav DOI: 10.1177/0883073813511855 jcn.sagepub.com
Inn-Chi Lee, MD1,2, Yung-Jung Chen, MD, PhD3, Hong-Shen Lee, PhD2, and Shuan-Yow Li, PhD2
Abstract The outcomes of children with cryptogenic seizures most probably arising from the frontal lobe are difficult to predict. We retrospectively collected data on 865 pediatric patients with epilepsy. In 78 patients with cryptogenic frontal lobe epilepsy, the age at first seizure was inversely correlated with the outcome, including the degree of intellectual disability/developmental delay (P ¼ .002) and seizure frequency (P ¼ .02) after adequate treatment. Intellectual disability was more prevalent in children with a first seizure at 0 to 3 years old (P ¼ .002), and seizures were more frequent in those with a first seizure at 0 to 6 years old than at 7 to 16 years old (P ¼ .026). For pediatric cryptogenic frontal lobe epilepsy, the age at first seizure is important and inversely correlated with outcome, including seizure frequency and intellectual disability. Keywords frontal lobe epilepsy, cryptogenic, child, outcome, prognosis Received March 19, 2013. Received revised September 17, 2013. Accepted for publication October 16, 2013.
Frontal lobe epilepsy accounts for as much as 30% of childhood epilepsy1; it is characterized by recurrent seizures originating in the frontal lobes, including the orbitofrontal, frontopolar, dorsolateral, opercular, and supplementary motor areas, as well as the motor cortex and cingulate gyrus.1,2 Features of frontal lobe seizures include a stereotyped semiology, occurrence during sleep, brief duration (often
Prognostic Factors for Outcome in Pediatric Probable Lesional Frontal Lobe Epilepsy With an Unknown Cause (Cryptogenic)
Journal of Child Neurology 2014, Vol. 29(12) 1660-1663 ª The Author(s) 2013 Reprints and permission: sagepub.com/journalsPermissions.nav DOI: 10.1177/0883073813511855 jcn.sagepub.com
Inn-Chi Lee, MD1,2, Yung-Jung Chen, MD, PhD3, Hong-Shen Lee, PhD2, and Shuan-Yow Li, PhD2
Abstract The outcomes of children with cryptogenic seizures most probably arising from the frontal lobe are difficult to predict. We retrospectively collected data on 865 pediatric patients with epilepsy. In 78 patients with cryptogenic frontal lobe epilepsy, the age at first seizure was inversely correlated with the outcome, including the degree of intellectual disability/developmental delay (P ¼ .002) and seizure frequency (P ¼ .02) after adequate treatment. Intellectual disability was more prevalent in children with a first seizure at 0 to 3 years old (P ¼ .002), and seizures were more frequent in those with a first seizure at 0 to 6 years old than at 7 to 16 years old (P ¼ .026). For pediatric cryptogenic frontal lobe epilepsy, the age at first seizure is important and inversely correlated with outcome, including seizure frequency and intellectual disability. Keywords frontal lobe epilepsy, cryptogenic, child, outcome, prognosis Received March 19, 2013. Received revised September 17, 2013. Accepted for publication October 16, 2013.
Frontal lobe epilepsy accounts for as much as 30% of childhood epilepsy1; it is characterized by recurrent seizures originating in the frontal lobes, including the orbitofrontal, frontopolar, dorsolateral, opercular, and supplementary motor areas, as well as the motor cortex and cingulate gyrus.1,2 Features of frontal lobe seizures include a stereotyped semiology, occurrence during sleep, brief duration (often
