Author's Accepted Manuscript
Prophylactic Pulmonary Vein Isolation During Isthmus Ablation for Atrial Flutter The PReVENT AF Study I Jonathan S. Steinberg MD, FHRS, Alexander Romanov MD, Dan Musat MD, Mark Preminger MD, Sevda Bayramova MD, Sergey Artyomenko MD, Vitaliy Shabanov MD, Denis Losik MD, Alexander Karaskov MD, Richard E. Shaw PhD, Evgeny Pokushalov MD
PII: DOI: Reference:
S1547-5271(14)00515-3 http://dx.doi.org/10.1016/j.hrthm.2014.05.011 HRTHM5774
To appear in:
Heart Rhythm
www.elsevier.com/locate/buildenv
Cite this article as: Jonathan S. Steinberg MD, FHRS, Alexander Romanov MD, Dan Musat MD, Mark Preminger MD, Sevda Bayramova MD, Sergey Artyomenko MD, Vitaliy Shabanov MD, Denis Losik MD, Alexander Karaskov MD, Richard E. Shaw PhD, Evgeny Pokushalov MD, Prophylactic Pulmonary Vein Isolation During Isthmus Ablation for Atrial Flutter The PReVENT AF Study I, Heart Rhythm, http://dx.doi.org/ 10.1016/j.hrthm.2014.05.011 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Prophylactic Pulmonary Vein Isolation During Isthmus Ablation for Atrial Flutter The PReVENT AF Study I Short Title: PReVENT AF Study Jonathan S. Steinberg, MD*, FHRS, Alexander Romanov, MD¶, Dan Musat, MD*, Mark Preminger, MD*, Sevda Bayramova, MD¶, Sergey Artyomenko, MD¶, Vitaliy Shabanov, MD¶, Denis Losik, MD¶, Alexander Karaskov, MD¶, Richard E. Shaw, PhD*, and Evgeny Pokushalov, MD¶ *The Arrhythmia Institute, Valley Health System New York, NY, and Ridgewood, NJ, USA ¶
State Research Institute of Circulation Pathology Novosibirsk, Russia
Address for correspondence: Jonathan S. Steinberg, MD, FAHA 200 West 57th Street, Suite 610 New York, NY 10019 212‐432‐7837 (voice) 212‐432‐7836 (fax) [email protected] Potential conflicts of interest: Jonathan S. Steinberg, MD; Consultant: Boston‐Scientific, Medtronic, St Jude Medical, Biosense‐Webster, Cameron Health, Topera, AliveCor, Sanofi aventis, Janssen, Philips, Ambucor. Research support: Medtronic, Biosense‐Webster, Boston‐Scientific. Speaker: Bristol‐Myers Squibb, Pfizer, Medtronic. All other authors report no conflicts of interest. This study was presented in part as a Late Breaking Clinical Trial at the 2014 Heart Rhythm Society Scientific Sessions in San Francisco, CA. Word Count: 4071
Clinical Trials Registration: NCT01563848
1
Abstract Background. Although catheter ablation of isthmus‐dependent atrial flutter (AFL) is successful at eliminating the target arrhythmia, many patients subsequently experience new onset atrial fibrillation (AF). Objective. To determine if AF can be prevented by prophylactic pulmonary vein ablation in patients with AFL. Methods. A prospective single‐blind randomized clinical trial in patients whose sole arrhythmia was AFL without AF was conducted. Patients were randomized to cavo‐ tricuspid isthmus ablation alone or with concomitant pulmonary vein isolation. All patients received an implantable cardiac monitor. Results. 50 patients completed the trial and patients were well‐matched. Isthmus ablation was successful in all patients; pulmonary vein isolation was successful in the 25 randomized patients. Procedure (p
Prophylactic Pulmonary Vein Isolation During Isthmus Ablation for Atrial Flutter The PReVENT AF Study I Jonathan S. Steinberg MD, FHRS, Alexander Romanov MD, Dan Musat MD, Mark Preminger MD, Sevda Bayramova MD, Sergey Artyomenko MD, Vitaliy Shabanov MD, Denis Losik MD, Alexander Karaskov MD, Richard E. Shaw PhD, Evgeny Pokushalov MD
PII: DOI: Reference:
S1547-5271(14)00515-3 http://dx.doi.org/10.1016/j.hrthm.2014.05.011 HRTHM5774
To appear in:
Heart Rhythm
www.elsevier.com/locate/buildenv
Cite this article as: Jonathan S. Steinberg MD, FHRS, Alexander Romanov MD, Dan Musat MD, Mark Preminger MD, Sevda Bayramova MD, Sergey Artyomenko MD, Vitaliy Shabanov MD, Denis Losik MD, Alexander Karaskov MD, Richard E. Shaw PhD, Evgeny Pokushalov MD, Prophylactic Pulmonary Vein Isolation During Isthmus Ablation for Atrial Flutter The PReVENT AF Study I, Heart Rhythm, http://dx.doi.org/ 10.1016/j.hrthm.2014.05.011 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Prophylactic Pulmonary Vein Isolation During Isthmus Ablation for Atrial Flutter The PReVENT AF Study I Short Title: PReVENT AF Study Jonathan S. Steinberg, MD*, FHRS, Alexander Romanov, MD¶, Dan Musat, MD*, Mark Preminger, MD*, Sevda Bayramova, MD¶, Sergey Artyomenko, MD¶, Vitaliy Shabanov, MD¶, Denis Losik, MD¶, Alexander Karaskov, MD¶, Richard E. Shaw, PhD*, and Evgeny Pokushalov, MD¶ *The Arrhythmia Institute, Valley Health System New York, NY, and Ridgewood, NJ, USA ¶
State Research Institute of Circulation Pathology Novosibirsk, Russia
Address for correspondence: Jonathan S. Steinberg, MD, FAHA 200 West 57th Street, Suite 610 New York, NY 10019 212‐432‐7837 (voice) 212‐432‐7836 (fax) [email protected] Potential conflicts of interest: Jonathan S. Steinberg, MD; Consultant: Boston‐Scientific, Medtronic, St Jude Medical, Biosense‐Webster, Cameron Health, Topera, AliveCor, Sanofi aventis, Janssen, Philips, Ambucor. Research support: Medtronic, Biosense‐Webster, Boston‐Scientific. Speaker: Bristol‐Myers Squibb, Pfizer, Medtronic. All other authors report no conflicts of interest. This study was presented in part as a Late Breaking Clinical Trial at the 2014 Heart Rhythm Society Scientific Sessions in San Francisco, CA. Word Count: 4071
Clinical Trials Registration: NCT01563848
1
Abstract Background. Although catheter ablation of isthmus‐dependent atrial flutter (AFL) is successful at eliminating the target arrhythmia, many patients subsequently experience new onset atrial fibrillation (AF). Objective. To determine if AF can be prevented by prophylactic pulmonary vein ablation in patients with AFL. Methods. A prospective single‐blind randomized clinical trial in patients whose sole arrhythmia was AFL without AF was conducted. Patients were randomized to cavo‐ tricuspid isthmus ablation alone or with concomitant pulmonary vein isolation. All patients received an implantable cardiac monitor. Results. 50 patients completed the trial and patients were well‐matched. Isthmus ablation was successful in all patients; pulmonary vein isolation was successful in the 25 randomized patients. Procedure (p
