HHS Public Access Author manuscript Author Manuscript

Pancreas. Author manuscript; available in PMC 2017 July 01. Published in final edited form as: Pancreas. 2016 July ; 45(6): 819–825. doi:10.1097/MPA.0000000000000657.

Prospective Study of Alcohol Drinking, Smoking and Pancreatitis: The Multiethnic Cohort Veronica Wendy Setiawan, PhD1,2, Stephen J. Pandol, MD3, Jacqueline Porcel, MS2, Lynne R. Wilkens, DrPH4, Loïc Le Marchand, MD, PhD4, Malcolm C. Pike, PhD1,5, and Kristine R. Monroe, PhD1 1Department

Author Manuscript

of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA 2Norris

Comprehensive Cancer Center, Keck School of Medicine of University of Southern California, Los Angeles, CA

3Division

of Gastroenterology, Departments of Medicine, Cedars-Sinai Medical Center and Department of Veterans Affairs, Los Angeles, CA

4Epidemiology 5Memorial

Program, University of Hawaii Cancer Center, Honolulu, HI

Sloan Kettering Cancer Center, New York, NY

Abstract Author Manuscript

Objectives—We conducted a prospective analysis of 145,886 participants in the Multiethnic Cohort to examine the relationship of alcohol drinking and smoking with pancreatitis. Methods—Pancreatitis cases were categorized as gallstone-related acute pancreatitis (GS AP) (N=1,065), non-GS AP (N=1,222), and recurrent acute (RAP)/chronic pancreatitis (CP) (N=523). We used the baseline questionnaire to identify alcohol intake and smoking history. Associations were estimated by hazard ratios (HRs) and 95% confidence intervals (CIs) using Cox models.

Author Manuscript

Results—Cigarette smoking was associated with non-GS AP and RAP/CP. Moderate alcohol intake was inversely associated with all types of pancreatitis in women (HRs=0.66 to 0.81 for