PROSTAGLANDINS PROSTAGLANDIN INTERSTITIAL

E INDUCXD CHANGES IN RENAL BLOOD FLOW, RENAL I&D ROSTATIC PRESSURE AND SODIUM EXCRETION IN THE RAT

C.R.

Long, Y. Kinoshita

and F.G. Knox

Nephrology Research Laboratories Department6 of Phyeiology h Biophysics and Medicine Mayo Medical School, Rochester, Minneeota 55905

ABSTRACT Prostaglandin E,, when infused into the renal artery of the dog, is a vasodilator and increases both renal interstitial hydrostatic pressure and sodium excretion. Similar studies in the rat, however, have been inconclusive. The present study examined the effect of prostaglandin Q infusion into the renal interstitium, by means of a chronically implanted matrix, on renal blood flow, renal interstitial hydrostatic pressure and sodium excretion in the rat. Prostaglandin E, was continuously infused directly into the kidney interstitium to mimic endogenous prostaglandin E, production by renal cells. The maximum change in each of these parameters occurred when 10e5 M PGE, was infused. Renal blood flow increased from 4.7020.91 to 54520.35 ml/min (p